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TGFβ-Smad3 signaling restores cell-autonomous Srsf1-mediated splicing of fibronectin in aged skeletal muscle stem cells - Nature Communications Aging impairs the regenerative capacity of skeletal muscle stem cells. Here, the authors identify a stem cell-specific fibronectin splice variant and show that its cell-autonomous secretion through th...

Please check out our latest publication showing that activated #muscle stem cells depend on a niche-restricted, autoregulatory #fibronectin splice variant that is strongly affected by #aging.

🔗 www.nature.com/articles/s41...

#StemCells #SkeletalMuscle #MuSCs #ExtracellularMatrix #Splicing

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