#NHPHIP

Kerti Ausmees

@kertiausmees.bsky.social

1 week ago

Welcome to the team Devika. We wish you an exciting and inspiring doctoral journey! #innochembio, #KBFI, #NMR, #NHPHIP

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Ruud

@70ra.bsky.social

6 months ago

Semi-Targeted Nuclear Magnetic Resonance Metabolomics via Parahydrogen-Induced Hyperpolarization for Enhanced Sensitivity to Metabolic Composition Non-hydrogenative para-hydrogen-induced polarization (nhPHIP) has proven a powerful tool for the enhanced NMR detection of several classes of metabolites in complex mixtures. Particularly, compounds carrying an α-amino acid motif have been previously detected and quantified in biological samples and natural extracts at submicromolar concentrations using 2D nhPHIP NMR spectroscopy. This technique is here applied for the first time in a semi-targeted metabolomics NMR study on urine from patients suffering from Pyridoxine-Dependent Epilepsy (PDE), currently diagnosed by the presence of dilute unique biomarkers. The signal enhancement, combined with the resolving power of 2D nhPHIP, results in a superior sensitivity to the metabolic composition compared to conventional 1H NMR, demonstrating its potential in NMR-based metabolomics.

Very pleased to see the paper is out! Congrats to PhD candidate Thom Posthumus on his @jacs.acspublications.org publication, a semi-targeted hyperpolarized NMR-based metabolomics study on Pyridoxine-Dependent Epilepsy (PDE).
#NMRchat #metabolomics #nhPHIP
pubs.acs.org/doi/10.1021/...

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Kerti Ausmees

@kertiausmees.bsky.social

7 months ago

Pleased to share our new paper! We tackle resolution & sensitivity limits in affordable benchtop #NMR using nhPHIP hyperpolarization to resolve a dilute mixture of 8 amino acids—expanding practical benchtop NMR use.
#hyperpolarization #nhPHIP #BenchtopNMR #ChemComm #NMRChat
doi.org/10.1039/D5CC...

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Kerti Ausmees

@kertiausmees.bsky.social

7 months ago

I'm pleased to share that our paper "Detection of Adenosine Phosphates in Blood by nh-PHIP" has been published in ACS Analytical Chemistry. #NMR #Hyperpolarization #ATP #metabolomics #nhPHIP

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Posts tagged #NHPHIP