Latest posts tagged with #NatMicroPicks on Bluesky
#NatMicroPicks
Sending evolution into overdrive 🔧🦠
A Φ29‑based DNA replication system in E. coli enables stable and targeted hypermutation achieving evolution of enzyme activities within days
#MicroSky
www.nature.com/articles/s41...
#NatMicroPicks
No-GMO enhanced Bt toxin 🦠🌱🪲
Naturally occurring 'sporesilk' matrix coating the Bacillus thuringiensis toxin crystals boosts insecticidal activity providing a non-GMO pest biocontrol.
#MicroSky
www.nature.com/articles/s41...
#NatMicroPicks
The versatile Acinetobacter baumannii! 🦠
The dreaded pathogen naturally occupies soil and airborne niches that underpin its recalcitrance and human contact may have shaped its evolution.
#MicroSky
www.nature.com/articles/s41...
#NatMicroPicks
Multi-kingdom microbial interplay in cancer 🦠🍄🦀⚕️
Candida albicans synergizes with Fusobacterium nucleatum in colorectal cancer offering a potential therapeutic target via L‑arginine disruption.
#MicroSky #CancerSky
www.cell.com/cancer-cell/...
#NatMicroPicks
Antibiotics in the long run ⌛💊🦠
Antibiotic use shows lasting associations with reduced gut microbial diversity for up to 8 years, indicating long-term impacts on the adult gut microbiome.
#MicroSky #MicrobiomeSky
www.nature.com/articles/s41...
#NatMicroPicks
A Microbial Atlas 🦠🗺️
MicrobeAtlas unifies >2 million microbiome samples into a resource that enables consistent cross‑study comparisons and ecological contextualization of both known and newly discovered species.
#MicroSky #MicrobiomeSky
www.cell.com/cell/fulltex...
#NatMicroPicks
Simulating a bacterium 💻🦠
A 4D whole-cell model of the minimal bacterium JCVI‑syn3A simulates its ~100‑minute cell cycle to reproduce experimental measurements and predict behaviours
#MicroSky
www.cell.com/cell/fulltex...
#NatMicroPicks
Therapeutic eye bacteria 🦠👁️🔧
Engineered eye‑colonizing bacteria deliver IL‑10 long‑term to reduce inflammation, and accelerate corneal wound healing.
#MicroSky
www.cell.com/cell-reports...
#NatMicroPicks
A microbial signature of health! 🦠⚕️
A large meta-analysis highlights the importance of previously unknown and uncultured gut bacteria in maintaining human health
#MicroSky
www.cell.com/cell-host-mi...
#NatMicroPicks
Fungi host invasion! 🍄🌱
Mechanism of fungal turgor generation, that aids mechanical host penetration by fungus could present new targets for disease control in plants
#MicroSky
www.science.org/doi/10.1126/...
#NatMicroPicks
Mpox transmission caught in action! 🐿️🦠🐒
A wild squirrel-to-mangabey interspecies transmission highlights the risk to the population that hunts these animals for food
#MicroSky
www.nature.com/articles/s41...
#NatMicroPicks
A broad respiratory vaccine! 🦠🫁💉
An intranasal liposomal vaccine combining TLR4 and TLR7/8 ligands with ovalbumin produced broad and durable respiratory protection in mice
#MicroSky
www.science.org/doi/10.1126/...
#NatMicroPicks
Aerobic archaeal-eukaryotic ancestor? 🦠🫁
The ancestor of eukaryotes may have combined hydrogen metabolism with aerobic respiration, shaping early cellular complexity.
#MicroSky
www.nature.com/articles/s41...
#NatMicroPicks
C. diff vaccine! 🦠💉
A protective mucosal vaccine formulation that provides sterilizing immunity to clear C. difficile from the host.
#MicroSky
www.nature.com/articles/s41...
#NatMicroPicks
FMT for cancers in clinic! 💩🦠🦀⚕️
Three different clinical trials report activity of faecal microbiota transplant against cancer
#MicroSky #CancerSky
www.nature.com/articles/s41...
www.nature.com/articles/s41...
#NatMicroPicks
It matters where cancer-associated bacteria are! 🦀💊
The spatial localization of bacteria associated with tumors dictates opposite immune outcomes - driving metastasis or triggering antitumour neutrophil activity
#MicroSky
www.cell.com/cell/fulltex...
#NatMicroPicks
Enhancing anti-fungals! 💊🍄
A natural‑product butyrolactol A restores caspofungin activity against intrinsically resistant Cryptococcus neoformans and multidrug‑resistant Candida auris
#MicroSy
www.cell.com/cell/fulltex...
#NatMicroPicks
Host enzyme, fungal targets! 🍄🦠
Intestinal epithelial cells secrete METTL9, a host methyltransferase that directly modifies fungal proteins to block essential zinc acquisition
#MicroSky
www.cell.com/cell-host-mi...
#NatMicroPicks
More than just pumps? 🦠💊
Bacterial efflux pumps not only block drug entry but also disrupt intracellular drug–target interactions by preventing repeated drug rebinding
#MicroSky
www.science.org/doi/10.1126/...
#NatMicroPicks
SFB aid microphages to fight flu! 🦠💉
Intestinal colonization with segmented filamentous bacteria reprograms alveolar macrophages to resist influenza‑induced depletion and prevent secondary bacterial infection
www.science.org/doi/10.1126/...
#MicroSky
#NatMicroPicks
T4 phage-based therapeutics! 💊
T4 phages engineered to produce a protease inhibitor that reduces inflammation-associated enzyme activity in a mouse model of ulcerative colitis
#MicroSky
www.nature.com/articles/s41...
#NatMicroPicks
E. coli can be engineered to secrete a glue consisting of an adhesive protein and a healing factor, inducible in response to gastrointestinal bleeding, to treat colitis in a mouse model
@natbiotech.nature.com
www.nature.com/articles/s41...
#NatMicroPicks
Identification of a 5500-year-old Treponema genome from human remains recovered in Colombia uncovers a new subspecies of Treponema pallidum, the cause of syphilis, and provides insights into its evolutionary history. @science.org
www.science.org/doi/10.1126/...
#NatMicroPicks
A bacterial symbiont wraps its flagllar filaments around its cell body to propel itself through narrow gut passages in its stinkbug host and hook flexibility is key for this 🪲🦠
by Yoshitomo Kikuchi & co @natcomms.nature.com
www.nature.com/articles/s41...
#NatMicroPicks Baby-to-baby strain transmission shapes the developing gut microbiome - out now in Nature! 👶🦠👶
#microsky #microbiome @nature.com @cibiocm.bsky.social
www.nature.com/articles/s41...
#NatMicroPicks
Asgard archaea and the origin of eukaryotes! 🦠
Eukaryotic cellular complexity evolved largely within the Asgard lineage before mitochondrial endosymbiosis and later bacterial gene acquisitions
#MicroSky
www.nature.com/articles/s41...
#NatMicroPicks
Rejuvenating antifungal activity! 🍄💊
Butyrolactol A inhibits a fungal lipid flippase to restore the activity of echinocandin against intrinsically resistant pathogens, highlighting lipid flippases as promising antifungal targets
#MicroSky
www.cell.com/cell/fulltex...
#NatMicroPicks
gut microbes protect from pneumonia! 🦠🫁
SFB colonization reprograms alveolar macrophages to resist influenza‑induced depletion and enhances their antibacterial function protecting mice from secondary bacterial pneumonia
#MicroSky
www.science.org/doi/10.1126/...
#NatMicroPicks
bacterial amino acid metabolism affects cancer progression 🦠🦀🐁
Bacteroides asparaginase lowers intestinal asparagine levels and drives colorectal tumor progression
#MicroSky
www.cell.com/cell-host-mi...
