Latest posts tagged with #Neointima on Bluesky
#SpatialTranscriptomics #Visium #VeinGraft #Neointima
Late-stage Neointimal cells in grafted vessels are More Contractile & Synthetic than regenerated Medial cells
FHL1 CRISPR KO Rat▶️hyper-inflammatory, dysmorphic intima
Clin Transl Med 2024
onlinelibrary.wiley.com/doi/full/10....
PDGF/Arterial injury->
Glycolysis (PFKFB3, synergizing with HIF1α)->
de novo Lipogenesis (FASN/ACLY/ACACA/B)->
#SmoothMuscleCell proliferation, lipid loading, loss of contractile phenotype in #Neointima
SMC FASN KO🐭->⏬Neointima
J Pathol 2023
pathsocjournals.onlinelibrary.wiley.com/doi/10.1002/...
#LongNonCodingRNA #SmoothMuscleCell
LncDACH1⏬SMC proliferation+migration & #Neointima of #ArterioVenousFistula, partially via ⏬HSP90 abundance & sequestrating SRPK1 in the nuclei
A similar pro-intimal role in #Atherosclerosis?
#NatureComms 2024
www.nature.com/articles/s41...
