Latest posts tagged with #NeuroPath on Bluesky
AANP Case of the Month
Credit: @JaredAhrendsen (for instagram: Jared T. Ahrendsen, MD, PhD, Northwestern University)
- 5-year-old child
- large, variably enhancing mass of the frontal region
- no evidence of extracranial disease
- Histology below
- Differential?
- IHC/stains? #neuropath
The answer is: Necrotizing Myopathy
To learn more, head to our blog: www.arkanalabs.com/needle-core-...
#neuropath #neuromuscular #neuronotes #pathology
We have launched four neuropathology quizzes on our website! If you're interested in testing your neuropathology wisdom, head to our site. #neuropathology #neuromuscular #pathology #neuropath #neuronotes
1/ What is the best pathologic diagnosis? Clinical history in thread.
#NeuroNotes #neuropath #pathology #neuromuscularpath
The answer is: Denervation (neurogenic atrophy) and incidental vascular amyloid deposition
To learn more, head to our blog: www.arkanalabs.com/denervation-...
#neuropath #neuromuscular #neuronotes #pathology
The answer is: Vacuolar myopathy due to hydroxychloroquine toxicity
To learn more, head to our blog: www.arkanalabs.com/toxic-vacuol...
#neuropath #neuromuscular #neuronotes #pathology
1/ This 50-year-old patient presented with a one yearhistory of of persistent muscle weakness. They also had shortness of breath with exertion.
#NeuroNotes #neuropath #pathology #neuromuscularpath
The answer is: D.) Duchenne muscular dystrophy
To learn more, head to our blog: www.arkanalabs.com/sporadic-lat...
#neuropath #neuromuscular #neuronotes #pathology
(1/2) The patient is a 69-year-old male who presented with complaints of proximal lower extremity muscle weakness and BMI of 37. His home medication list includes atorvastatin. Bilateral thigh biopsies were performed to evaluate for myopathy.
#NeuroNotes #neuropath #pathology #neuromuscularpath
The answer is: Collagen pockets
To learn more, head to our blog: www.arkanalabs.com/collagen-poc...
#neuropath #neuromuscular #neuronotes #pathology
(1/3) This 40-year-old patient underwent sural nerve biopsy to evaluate for a painful mixed large fiber and small fiber axonal neuropathy. The biopsy showed light microscopic features of a chronic active axonopathic process.
#NeuroNotes #neuropath #pathology #neuromuscularpath
The answer is: The terminal boutons of the motor axons are missing from the neuromuscular junction (NMJ).
To learn more, head to our blog: www.arkanalabs.com/denervated-n...
#neuropath #neuromuscular #neuronotes #pathology
(2/2) What abnormality is seen in the electron microscopic images #1 - #3 of neuromuscular junction present in this patient’s muscle biopsy? For comparison, image #4 is from a normal neuromuscular junction?
#neuropath #neuromuscular
(1/2) Muscle biopsy from this 40-year-old patient showed morphologic and enzyme histochemical features of denervation.
#NeuroNotes #neuropath #pathology #neuromuscularpath #neurosky #pathsky
The answer is: C.) PCR fragment analysis of DPMK
To learn more, head to our blog: www.arkanalabs.com/ring-fibers/
#neuropath #neuromuscular #neuronotes #pathology #pathX
Answer choices:
A.) PCR fragment analysis of CNBP
B.) Muscular dystrophy gene panel
C.) PCR fragment analysis of DPMK
D.) Myositis specific antibody panel
#NeuroNotes #neuropath #pathology #neuromuscularpath #neurosky #pathsky
Which genetic test is required to establish the diagnosis in this 59-year-old with distal muscle weakness, mild myotonia, and persistently elevated CPK values (200-300 U/L)?
#NeuroNotes #neuropath #pathology #neuromuscularpath #neurosky #pathsky
The answer is: Denervation, reinnervation, and myofibrillar myopathy
To learn more, head to our blog: www.arkanalabs.com/vacuolar-myo...
#neuropath #neuromuscular #neuronotes #pathology #pathX
The answer is hybrid myofibers.
To learn more, head to our blog: www.arkanalabs.com/hybrid-myofi...
#neuropath #neuromuscular #neuronotes #pathology #pathsky
Muscle fiber typing was performed with dual immunohistochemical staining for fast and slow myosin heavy chains (MHCf-brown / MHCs-red).
What do the fibers showing intermediate staining (reddish-brown) represent?
#neuropath #pathology #neuromuscularpath
This previously healthy 35-year-old patient presented with proximal upper and lower extremity weakness and myalgias. Laboratory studies showed normal CPK. The patient's home medication is negative for myotoxic medications.
#NeuroNotes #neuropath #pathology #neuromuscularpath
Season 2 of Visiting Joel is here! This season, we follow visiting physician Dr. Archana Gudipati as she learns more about renal pathology, neuromuscular pathology, and electron microscopy. #pathology #renalpath #neuropath
Click here for episode 1: youtu.be/H-g-G64xsbE
Correct Answer: Amyloidosis
Head to our blog for a more detailed explanation and additional reading: www.arkanalabs.com/76-year-old-...
#neuropath #neuromuscular #neuronotes #pathology
🎙️ Join us for Grand Rounds on Fri 7/25 at 8:00 AM PT featuring Dr. Meaghan Morris presenting on "Combing Pathology and Spatial Transcriptomics to Investigate Aging and Alzheimer's Disease."
Full schedule here ➨ bit.ly/3BMx0E3
#Pathology #Path2Path #PathSky #neuropath
(1/3) The patient is a 76-year-old man with numerous complaints including weakness, myalgia, arthralgia, back pain radiating down bilateral legs, cramps and twitching, imbalance, speech disorder, difficulty walking, and numbness.
#NeuroNotes #neuropath #pathology #neuromuscularpath
Diagnosis: Neuromuscular junction (aka motor end-plate)
Head to our blog for a more detailed explanation and additional reading: www.arkanalabs.com/neuromuscula...
#neuropath #neuromuscular #neuronotes #pathology #pathX
Muscle bx was performed on 60 y/o patient w/ complaints of muscle weakness. Several small intramuscular nerve twigs were noted on glutaraldehyde-fixed toluidine blue stained thick sections.
What normal structure is demonstrated in the electron microscopy images?
#NeuroNotes #neuropath #pathology
Image of the Week!
Submitted by: Gabrielle Yeaney, M.D.
Directory Profile: www.pathologyoutlines.com/directory/ga...
Subspecialty: Neuropathology
Diagnosis: Normal pineal gland
#Pathology #PathologyOutlines #NeuroPath #PathSky
A 19-year-old man presented with brain tumor at pineal region and cerebellar region.
AE1/AE3 : weak staining
GFAP: focal near 50%
High Ki-67 proliferative index=60%
What is it?
#neuropath #pathology #pathsky #histology #CNStumor #CNSpath
