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Latest posts tagged with #RNAediting on Bluesky

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Posts tagged #RNAediting

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Today we released our 2025 year end financial results and provided a business update.

Read the full press release on our website: www.proqr.com/press-releas...

$PRQR #Biotech #Axiomer #RNAediting

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Driven by a deep curiosity about molecular biology, Seda translates emerging science into strategic direction in her role as Senior Director, Research Strategy and Innovation at ProQR.

Explore Seda’s profile and meet other members of #TeamProQR on our website: bit.ly/4b3BCXZ

#RNAEditing #Axiomer

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At #TIDESAsia in Tokyo, our Chief Scientific Officer, Gerard Platenburg, shared how we are translating #Axiomer #RNAEditing into liver and CNS applications.

You can explore the presentation here:
www.proqr.com/presentation...

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Sepsis Breakthrough: RNA Editing with Bio-engineered Viruses
Sepsis Breakthrough: RNA Editing with Bio-engineered Viruses YouTube video by Bio sapiens

Xi et al. (2026) present in vivo chemogenetic RNA editing of macrophages by bioengineered viruses for sepsis treatment. This shows a new path of how to control inflammation using cell-specific gene editing and delivery. #Sepsis #RNAEditing #Immunotherapy Check out the video!
youtu.be/yPYOh3iS9WI

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Study explores how reversible RNA editing could transform future cardiovascular medicine This mini-review synthesises evidence showing that adenosine-to-inosine RNA editing plays an important regulatory role in cardiovascular development, cellular homeostasis, and disease biology. It high...

🧬 Could reversible RNA editing redefine heart disease care? Scientists are unlocking how this molecular switch may pave the way for precision therapies and new biomarkers. www.news-medical.net/news/2026021... #Cardiology #RNAEditing #Biotechnology @commsbio.nature.com

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Carles is a Researcher at ProQR, combining a passion for biology with hands-on #RNAEditing research. Beyond the lab, he actively supports an inclusive and welcoming culture as part of the DEI team!

Meet more members of the ProQR team: bit.ly/3M09Gvm

#Axiomer #TeamProQR

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Inositol hexakisphosphate Functions as a Cofactor and Modulator of ADAR1 Activity Adenosine-to-inosine (A-to-I) RNA editing, catalyzed by adenosine deaminases acting on RNA (ADARs), is a key post-transcriptional modification that regulates RNA splicing, stability, and translation. Dysregulation of ADAR activity caused by mutations in ADAR1 leads to Aicardi-Goutieres syndrome (AGS), an autoimmune disorder characterized by aberrant activation of Melanoma differentiation-associated protein 5 (MDA5) by self RNA and excessive type I interferon production. Despite its biological and clinical relevance, the regulation of ADAR1 activity remains incompletely understood. Here, we show that ADAR1 protein levels and RNA editing activity in mammalian cells critically depend on the cofactor inositol hexakisphosphate (IP6). Using Inositol-pentakisphosphate 2-kinase (IPPK)-knockout cells, next-generation sequencing (NGS), and a cell-permeable IP6 prodrug (Pro-IP6), we demonstrate that IP6 depletion drastically reduces global RNA editing, while supplementation with Pro-IP6 restores and even enhances editing levels. In vitro ADAR1 translation and RNA editing assays revealed that IP6 contributes to the folding and full catalytic activity of ADAR1, and that inositol pentakisphosphate (1,3,4,5,6-IP5) can partially substitute IP6 as a cofactor. Molecular dynamics simulations and biochemical analyses identified the C6-phosphate of IP6 as a critical determinant of ADAR1 catalytic efficiency, functioning within a hydrogen-bonding network that indirectly governs Zn2+-ion positioning through interactions with key residues, including K1039 and N907. Notably, the AGS-associated N907S mutation impairs RNA editing, by altering IP6 coordination and introducing a more dynamic situation in the hydrogen-bonding network that linked IP6 and Zn2+-ion. Together, these findings identifies IP6 as an essential cofactor and regulator of ADAR1 activity and highlights cofactor availability and interaction networks as potential strategies for therapeutically modulating RNA editing in disease. ### Competing Interest Statement The authors have declared no competing interest. Deutsche Forschungsgemeinschaft, Project-ID 369799452— TRR237 - A02, Project-ID 548714673, CIBSS – EXC-2189 – Project ID 390939984 Volkswagen Foundation, VW Momentum Grant 98604 Israel Science Foundation, 2637/23 Medical Research Council, MR/T028904/1

If you are interested in RNA editing, ADAR1, or inositol phosphates, you may find our new preprint of interest.
“Inositol hexakisphosphate functions as a cofactor and modulator of ADAR1 activity”
Preprint available on @biorxivpreprint.bsky.social
www.biorxiv.org/content/10.6...
#ADAR1 #RNAEditing

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Check out the full PR here: bit.ly/4qcxvzb

#Axiomer #RNAEditing

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RNA editing fine-tunes transcriptional plasticity and enhances the adaptability of Myzus persicae to diverse host plants
Chen, Y. et al.
Paper
Details
#RNAediting #transcriptionalplasticity #Myzuspersicae

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College of Medicine, National Taiwan University.

College of Medicine, National Taiwan University.

Me and members of the Huang lab.

Me and members of the Huang lab.

Post image Me and Dr. Hsien-Sung Huang.

Me and Dr. Hsien-Sung Huang.

Thank you, Dr. Hsien-Sung Huang for hosting me during my stay in #Taipei & for inviting me to present my work at #NationalTaiwanUniversity. I had a wonderful time talking #organoids, #AlternativeSplicing, #RNAediting, & Rbfox 3.

Huang lab (黃憲松實驗室) share.google/Rv5o6uwhByHV...

#Taiwan
#IonChannels

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Our recent edition of the Axiomer Summit brought insightful discussions, a dynamic poster session, and exciting platform updates.

Thanks to our SAB and Board for their valuable contributions!

#RNAEditing #Axiomer #Biotech

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#RNAEditing #PulmonaryArterialHypertension

ADAR1 (both p150 & p110 isoforms) ⬇️in 👤PAH (in 🫁vascular smooth muscle cell)

SMC ADAR1 KO🐭 excerbates PAH

SMC ⏫dsRNA➡️⏫PKR-eIF2B-IFNβ➡️
Macrophage M1 polarization➡️
SMC proliferation

@kekeyuan.bsky.social #CircRes 2025
www.ahajournals.org/doi/10.1161/...

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Great to connect with the community at #TIDESEU in Basel last week. Gerard Platenburg, our Chief Scientific Officer, presented on translating #Axiomer RNA Editing science into targeted CNS applications.

Check out the presentation here: bit.ly/3K2y927

#RNAEditing

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🔍From #IL6 in #BipolarDisorder 🧬 to #RNAediting + #AI 🤖 diagnosing #Schizophrenia—science is bridging bench to bedside 💡 @mdpiopenaccess.bsky.social #Neuroimmunology #Biomarkers www.mdpi.com/1422-0067/26...

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IDT President Ajay Gannerkote explores how #AI is transforming #lifesciences—it’s converging with #genomics to accelerate #precisionmedicine, uncover new drug targets, and pioneer cutting-edge therapies like #RNAediting. Learn more in AI Journal here: https://bit.ly/3Xkh4ns

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🧬 AMBER: RNA editing game-changer! Precise C-to-U conversion without DNA damage. 21% efficiency in mouse models = huge potential for genetic disease treatment 🔬 #GenomicMedicine #RNAEditing #Biotech https://emmecola.github.io/genomics-daily

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The replay of our Investor and Analyst Event is now available: bit.ly/43PqFWS

Thanks to Professor Verkade for joining us! We are delighted that AX-0810 progressing to the clinic.

#Axiomer #RNAEditing $PRQR

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Join us in 60 mins for our virtual Investor and Analyst Event with ProQR Management and KOL Prof. Henkjan Verkade, MD, PhD (UMC Groningen).

Register for the event here: bit.ly/3Lb7GzE

#Axiomer #RNAEditing $PRQR

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🔍From #IL6 in #BipolarDisorder 🧬 to #RNAediting + #AI 🤖 diagnosing #Schizophrenia—science is bridging bench to bedside 💡 @mdpiopenaccess.bsky.social #Neuroimmunology #Biomarkers www.mdpi.com/1422-0067/26...

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Join us Nov 3 at 10:00 ET for our virtual Investor and Analyst Event with the ProQR Management and KOL Prof. Henkjan Verkade, MD, PhD (UMC Groningen).

Register for the event here: bit.ly/3Lb7GzE

#Axiomer #RNAEditing

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October marks #RettSyndromeAwarenessMonth, a time to shine a light on Rett syndrome.

At ProQR, we are proud to partner with the Rett Syndrome Research Trust developing #Axiomer #RNAEditing oligonucleotides to target genetic variants that cause Rett syndrome.

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We’re excited to share that our CTA for the Phase 1 study of AX-0810 in healthy volunteers has been authorized!

Join our virtual Investor and Analyst Event Nov 3, 10:00 ET.

For more details, check out the PR: bit.ly/3LjRCLX

#Axiomer #RNAEditing

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David, Senior Scientist at ProQR, plays a key role in advancing cell biology research while also contributing to team leadership and workplace culture.

Meet the rest of our team at: bit.ly/4nbVZWR

#Axiomer #RNAEditing #TeamProQR

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Synergy between RNA editing and alternative splicing modulates the biological properties of the voltage-gated calcium channel CaV1.3 Alternative splicing and adenosine-to-inosine (A-to-I) RNA editing are post-transcriptional mechanisms that promote proteomic diversity in the brain. The impact of RNA editing on brain physiology is u...

🚨 New paper alert! 🚨

Our paper entitled: "Synergy between RNA editing and alternative splicing modulates the biological properties of the voltage-gated calcium channel CaV1.3" is out now on Journal of Biological Chemistry!

www.jbc.org/article/S002...

#AlternativeSplicing #RNAediting

🧵 👇

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In-depth analysis of the RNA editing landscape in intracranial aneurysms and its potential role in alternative splicing. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.09.021

In-depth analysis of the RNA editing landscape in intracranial aneurysms and its potential role in alternative splicing. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.09.021

🔗 In-depth analysis of the RNA editing landscape in intracranial aneurysms and its potential role in alternative splicing. Computational and Structural Biotechnology Journal, DOI: doi.org/10.1016/j.cs...

📚 CSBJ: www.csbj.org

#RNAediting #Neuroscience #Genomics #PrecisionMedicine #BrainHealth

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Small Nuclear RNA Base Editing a Safer Alternative to CRISPR, UC San Diego Researchers Find Genetic editing holds promise to treat incurable diseases, but the most popular method — CRISPR — sometimes does more harm than good. A new study from University of California San Diego and Yale…

Genetic editing holds promise to treat incurable diseases, but #CRISPR sometimes does more harm than good. @UCSanDiego.bsky.social and @Yale.edu researchers report a new, potentially safer method: small nuclear #RNAediting.

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Adenosine-to-inosine editing of miR-200b-3p is associated with the progression of high-grade serous ovarian cancer

👉 buff.ly/FMrZvtO

#HGSOC #miR200 #RNAediting

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Lemelinda pairs her passion for RNA biology with research, protocol development & biosafety support, while also fostering a strong community at ProQR through our Coffee & Collaboration Café.

Meet more of the ProQR team at: bit.ly/45ZFtmq

#Axiomer #RNAEditing #TeamProQR

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graphic with text "Financial Filings" and sub text that reads "2025 Q2 Report"

graphic with text "Financial Filings" and sub text that reads "2025 Q2 Report"

Today we announced our Second Quarter 2025 Operating and Financial Results. Read the press release here: bit.ly/4fwEU7Y
$PRQR #RNAEditing #Axiomer

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Genetic changes in an RNA-editing enzyme reduce editing of a brain receptor gene, leading to abnormal receptor function, neuronal overactivity, seizures, and developmental delay.
#RNAediting #Neurodevelopment bit.ly/3TGUN1i

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