Latest posts tagged with #AlternativeSplicing on Bluesky
⭐ #NARBreakthrough! ⭐
🧬 New study uncovers how #RNAstructures control stochastic exon selection in Dscam1 genes. #Balancer RNA structures and a #multi-subunit RNA architecture coordinate spatial and temporal splicing 🔬✨
Read the full article here: doi.org/10.1093/nar/...
#AlternativeSplicing
#AlternativeSplicing analysis pipeline
MAJIQ v2 - VOILA v2 modulizer
👉Build gene splicegraph including unannotated, complex elements (e.g. de novo intron retention)
👉Quantify AS events & modules
👉Comparative analysis of GTEx v8 all 53 tissues
#NatComm 2023
www.nature.com/articles/s41...
🚨 New paper alert! 🚨
Our method paper entitled: "Semi-quantitative RT-PCR Assay for the Analysis of Alternative Splicing of Interleukin Genes" is out now on the volume "Immune Mediators in Cancer"!
🧵 Thread 👇
#AlternativeSplicing
#SpliceVariant
#Interleukins
#Cytokines
#AlternativeSplicing
Systematic profiling of AS program & splicing factors (RBPMS, RBFOX2, MBNL1/2, Quaking) in Smooth Muscle Cell
RBPMS, RBFOX2 & MBNL1/2, but not QK, are pro-contractile in PAC1 SMC
#NucAcidRes 2025
academic.oup.com/nar/article/...
This #STTT study shows that hnRNPR regulates m6A-dependent #AlternativeSplicing of Skap2, positioning it as a key regulator of #Spermiogenesis, while highlighting mEVs-SKAP2 as a promising #TherapeuticTarget.
#OpenAccess: doi.org/10.1038/s413...
College of Medicine, National Taiwan University.
Me and members of the Huang lab.
Me and Dr. Hsien-Sung Huang.
Thank you, Dr. Hsien-Sung Huang for hosting me during my stay in #Taipei & for inviting me to present my work at #NationalTaiwanUniversity. I had a wonderful time talking #organoids, #AlternativeSplicing, #RNAediting, & Rbfox 3.
Huang lab (黃憲松實驗室) share.google/Rv5o6uwhByHV...
#Taiwan
#IonChannels
#Review in #MedComm
Alternative Splicing: Molecular Mechanisms, Biological Functions, Diseases, and Potential Therapeutic Targets doi.org/10.1002/mco2...
#AlternativeSplicing #BiologicalFunction #disease #MolecularMechanism #TherapeuticTarget
While reaching for cookies, we stumbled on a treat of a different kind: DIGGER 2.0 for exploring the functional role of protein interactions in #AlternativeSplicing! ☃️🍪
Now supporting the mouse interactome and the functional enrichment tool NEASE #CoSyAdventcalender
👉 exbio.wzw.tum.de/digger/
Robust Integration of Sparse Single-Cell Alternative Splicing and Gene Expression Data with SpliceVI
Isaev, K. et al.
Paper
Details
#SingleCell #AlternativeSplicing #SpliceVI
Advancing automated cell type annotation with large language models and single-cell isoform sequencing. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.11.008
🔗 Advancing automated cell type annotation with large language models and single-cell isoform sequencing. Computational and Structural Biotechnology Journal, DOI: doi.org/10.1016/j.cs...
📚 CSBJ: www.csbj.org
#LargeLanguageModels #Genomics #CellBiology #AlternativeSplicing #LLMs #SystemsBiology
KAT2A-mediated #succinylation of the #splicingfactor SRSF11 at K419 enhances #DNARepair and #radioresistance in #HCC by promoting RAD52 exon inclusion, linking #AlternativeSplicing to #GenomicStability and offering a potential therapeutic target.
#STTT: doi.org/10.1038/s413...
Schematic model depicting the role of PRMT5-mediated symmetric arginine dimethylation in regulation of TCF3 alternative splicing under normoxia (left) and hypoxia (right). Created in BioRender. Shukla, S.
PRMT5 is a #HistoneMethyltransferase upregulated in various cancer types. This study shows that PRMT5 regulates TCF3 #AlternativeSplicing under #hypoxia and that this promotes #EMT and invasion of #BreastCancer cells @plosbiology.org 🧪 plos.io/48ZbZrT
Schematic model depicting the role of PRMT5-mediated symmetric arginine dimethylation in regulation of TCF3 alternative splicing under normoxia (left) and hypoxia (right). Created in BioRender. Shukla, S.
PRMT5 is a #HistoneMethyltransferase upregulated in various cancer types. This study shows that PRMT5 regulates TCF3 #AlternativeSplicing under #hypoxia and that this promotes #EMT and invasion of #BreastCancer cells @plosbiology.org 🧪 plos.io/48ZbZrT
Schematic model depicting the role of PRMT5-mediated symmetric arginine dimethylation in regulation of TCF3 alternative splicing under normoxia (left) and hypoxia (right). Created in BioRender. Shukla, S.
PRMT5 is a #HistoneMethyltransferase upregulated in various cancer types. This study shows that PRMT5 regulates TCF3 #AlternativeSplicing under #hypoxia and that this promotes #EMT and invasion of #BreastCancer cells @plosbiology.org 🧪 plos.io/48ZbZrT
🚨 New paper alert! 🚨
Our paper entitled: "Synergy between RNA editing and alternative splicing modulates the biological properties of the voltage-gated calcium channel CaV1.3" is out now on Journal of Biological Chemistry!
www.jbc.org/article/S002...
#AlternativeSplicing #RNAediting
🧵 👇
Predicting the structural impact of human alternative splicing. #AlternativeSplicing #GenomeBiology
genomebiology.biomedcentral.com/articles/10....
Multiomics analyses of #SCLC #tumors reveals widespread #AlternativeSplicing and frequent #FocalAdhesionKinase splicing variants that drive aggressive disease, predict poor prognosis, & show marked sensitivity to FAK inhibitors. #medsky
#STTT #OpenAccess: doi.org/10.1038/s413...
Good morning Sky-Friends!
Our own @biochemtrix.bsky.social (and occasional poster!) is in Germany at the #Unleash consortium meeting. They are joining us here in the sky @unleash-as.bsky.social so follow along to find out about #AlternativeSplicing!
It's day 2 of the UNLEASH meeting! We are in beautiful Bernried and looking forward to hearing more about the progress our members have made unpicking the details of #AlternativeSplicing!
We are all here in sunny Munich to talk about the progress we have all made UNLEASHing the secrets of #AlternativeSplicing
Members of four different scientific groups across three different countries collaborating and sharing data.
Follow us to see our progress too!
This exciting issue includes articles on #AI and #Huanglongbing resistance, vertical farming, #reviews on genetic variation in adaptive #evolution, and on #AlternativeSplicing, along with much more research!
Read more great #PlantScience from this issue here: onlinelibrary.wiley.com/toc/17447909...
Computational workflow to analyze #AlternativeSplicing
vast-tools
Matt
ExOrthist
VastDB (vertebrate database) vastdb.crg.eu/wiki/Main_Page
PastDB (A. thaliana database) pastdb.crg.eu/wiki/About
Manuel Irimia lab #MethodMolBiol 2022
link.springer.com/protocol/10....
Our new review about RNA processing and mechanotransduction is out in Cell Reports! Link: lnkd.in/edApA4ZT. Proud of our very talented graduate student Gabrielle Bais and thankful to our institution and funding sources: UNC-Chapel Hill, NIH, NSF.
#mechanotransduction #RNA #alternativesplicing
This study reveals that TPM3P9 promotes #tumor growth in #ClearCellRenalCellCarcinoma (ccRCC) by enhancing the #alternativesplicing of oncogenic RNAs and highlights it as a potential therapeutic target in ccRCC management. #medsky
#STTT #OpenAccess: doi.org/10.1038/s413...
Presenting DIGGER 2.0: we extended our #AlternativeSplicing software DIGGER with new functionalities, including support of the mouse interactome and NEASE for #EnrichmentAnalysis! Check it out here: exbio.wzw.tum.de/digger/
Discover a new tool: DIGGER 2.0 enables splice-aware functional annotation of interaction network changes using RNA seq analysis via NEASE.
#VirusBioinformatics #AlternativeSplicing #InteractomeTools
📄 doi.org/10.1093/nar/...
👤EVBC: Olga Kalinina
🛠️ Resources
All code, datasets, and reproducible pipelines are openly available: github.com/alihamraoui/...
#bioinformatics #RNAseq #singlecell #alternativesplicing #benchmark #opensource #scRNAseq #MinION
cc @fr-genomics.bsky.social @mthomaschollier.bsky.social
Single cell and spatial alternative splicing analysis with Nanopore long read sequencing. #SingleCell #scRNAseq #AlternativeSplicing #LongReads #Sequencing @nanoporetech.com @natcomms.nature.com
www.nature.com/articles/s41...
Next Up in the #LongTREC Series 📽️ : Yalan Bi!
Yalan is a LongTREC Doctoral Candidate working with Ralf Herwig at @molgen.mpg.de Yalan shares insights into her research project and her experience as part of the LongTREC network. #LongReadsTranscriptomics #AlternativeSplicing #ProteinInteraction
📢 #PaperAlert
Review article in @WIREs_Reviews on #AlternativeSplicing, voltage-gated #calcium #channels, and #channelopathies. #IonChannels
Alternative Splicing and CaV‐Associated Channelopathies - Munyao - 2025 - WIREs RNA - Wiley Online Library wires.onlinelibrary.wiley.com/doi/10.1002/...
