Latest posts tagged with #RNAi on Bluesky
La vida como científico es sacrificada pero también gratificante. Y a veces gratamente inesperada. Hoy la empresa @alnylampharma.bsky.social experta en terapias #RNAi para #enfermedadesraras inaugura una sala de seminarios en su sede en Madrid a la que ha decidido poner mi nombre. Un inmenso honor.
🏆 2025 Top Downloaded Papers
Silencing of juvenile hormone-related genes through RNA interference leads to molt failure and high mortality in the spongy moth #OpenAccess #RNAi
onlinelibrary.wiley.com/doi/10.1111/...
RNA interference therapies are opening new frontiers in precision genetic medicine. #RNAi #GeneTherapy #Biotechnology www.wiseguyreports.com/fr/reports/r...
🧬 RNAi therapies drive next-gen gene silencing treatments. Explore: www.wiseguyreports.com/ja/reports/r... #RNAi
Funding will take startup through IND-enabling studies of RNAi programs targeting diseases including Alzheimer’s and Parkinson’s.
vist.ly/4qxtk
#longevity #investment #biotech #RNAi #Alzheimers #Parkinsons
Deal takeaways - Strong platform validation for Shengyin’s RNAi chemistry and delivery technologies - Meaningful non-dilutive capital with retained upside via milestones and royalties - Genentech assumes late-stage development and commercialization risk, a classic risk-sharing structure - Signals continued Big Pharma appetite for RNAi assets, especially platform-driven programs From an investment perspective, this deal highlights how differentiated RNA platforms can command premium economics even at early clinical stages—and how large pharma is selectively re-entering RNAi with improved delivery solutions.
RNAi deal worth watching from an investment lens
SanegeneBio announced a global licensing agreement with Genentech (罗氏公司 Group) for an RNAi therapeutic, featuring $200M upfront, up to $1.5B in milestones, plus tiered royalties.
#BiotechInvesting #RNAi #LicensingDeals #PharmaBD #Roche #Genentech
Top: FK506-resistant strains isolated from the Mucor circinelloides complex. Phenotypic analysis of FK506-resistant isolates in Mucor janssenii CBS185.68 (PS1), Mucor bainieri CBS293.63 (PS3), and Mucor atramentarius CBS202.28 (PS6). WT, wild-type; M, mendelian mutant; E, epimutant. Bottom: Schematic overview of epigenetic silencing contributing to antifungal resistance in Mucor species. fkbA expression enables FKBP12 production and FK506 sensitivity (yeast-like morphology). Epigenetic silencing of fkbA via RNAi and/or heterochromatin leads to FK506 resistance and hyphal growth. Generated with BioRender.com.
#Antifungal resistance is a global threat, but epigenetic mechanisms drive rapid, reversible adaptation in fungi. This study shows that #RNAi or #heterochromatin driven #epimutations transiently silence the gene fkbA to confer FK506 #tacrolimus resistance in #Mucor @plosbiology.org 🧪 plos.io/4qdttWc
Top: FK506-resistant strains isolated from the Mucor circinelloides complex. Phenotypic analysis of FK506-resistant isolates in Mucor janssenii CBS185.68 (PS1), Mucor bainieri CBS293.63 (PS3), and Mucor atramentarius CBS202.28 (PS6). WT, wild-type; M, mendelian mutant; E, epimutant. Bottom: Schematic overview of epigenetic silencing contributing to antifungal resistance in Mucor species. fkbA expression enables FKBP12 production and FK506 sensitivity (yeast-like morphology). Epigenetic silencing of fkbA via RNAi and/or heterochromatin leads to FK506 resistance and hyphal growth. Generated with BioRender.com.
#Antifungal resistance is a global threat, but epigenetic mechanisms drive rapid, reversible adaptation in fungi. This study shows that #RNAi or #heterochromatin driven #epimutations transiently silence the gene fkbA to confer FK506 #tacrolimus resistance in #Mucor @plosbiology.org 🧪 plos.io/4qdttWc
Top: FK506-resistant strains isolated from the Mucor circinelloides complex. Phenotypic analysis of FK506-resistant isolates in Mucor janssenii CBS185.68 (PS1), Mucor bainieri CBS293.63 (PS3), and Mucor atramentarius CBS202.28 (PS6). WT, wild-type; M, mendelian mutant; E, epimutant. Bottom: Schematic overview of epigenetic silencing contributing to antifungal resistance in Mucor species. fkbA expression enables FKBP12 production and FK506 sensitivity (yeast-like morphology). Epigenetic silencing of fkbA via RNAi and/or heterochromatin leads to FK506 resistance and hyphal growth. Generated with BioRender.com.
#Antifungal resistance is a global threat, but epigenetic mechanisms drive rapid, reversible adaptation in fungi. This study shows that #RNAi or #heterochromatin driven #epimutations transiently silence the gene fkbA to confer FK506 #tacrolimus resistance in #Mucor @plosbiology.org 🧪 plos.io/4qdttWc
Areca palm velarivirus 1 encoded CP suppresses antiviral RNA silencing by mediating the autophagic degradation of SGS3 and disrupting the SGS3–RDR6 interaction
Jiawei Wen, Huili Li … Xianmei Cao, Xi Huang
link.springer.com/article/10.1...
#Autophagic #HostAntiviral #RNAi #Nicotiana
There are few successful or sustainable ways to tackle the spotted wing drosophila, a notorious #fruit pest, but delivering #RNAi interference via yeast (and some Coca-Cola) looks very promising.
farmingfuturefood.com/next-generat...
#farming #agritech #genetics #scicomm
Breakthrough gene-silencing therapies are accelerating the RNAi Technology Market. Explore biotech trends! www.marketresearchfuture.com/reports/rnai...
#RNAi #GeneTherapy #Biotechnology
![dsRNA injection to N. vectensis zygotes triggers mild and transient gene knockdown. Top: Schematic representation of the dsRNA carrying eGFP sequence used in this study and of the transgene of the actin::eGFP line [40]. Bottom left: Heterozygous actin::eGFP embryos showing dimmer eGFP fluorescence 24 hpi of dsRNA carrying eGFP sequence (left) compared to scrambled eGFP sequence (right). Scale bars represent 500 µm. Bottom right: No difference in eGFP fluorescence of heterozygous actin::eGFP embryos is exhibited 72 hpi of dsRNA carrying eGFP sequence (left) compared to scrambled eGFP sequence (right). Scale bars represent 500 µm.](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:5522ztebtekoor5efelihqhb/bafkreibcytm7tkd5lfkqqb3opea5ptwopbn3yzlw633irru3v6eq2azxtq)
dsRNA injection to N. vectensis zygotes triggers mild and transient gene knockdown. Top: Schematic representation of the dsRNA carrying eGFP sequence used in this study and of the transgene of the actin::eGFP line [40]. Bottom left: Heterozygous actin::eGFP embryos showing dimmer eGFP fluorescence 24 hpi of dsRNA carrying eGFP sequence (left) compared to scrambled eGFP sequence (right). Scale bars represent 500 µm. Bottom right: No difference in eGFP fluorescence of heterozygous actin::eGFP embryos is exhibited 72 hpi of dsRNA carrying eGFP sequence (left) compared to scrambled eGFP sequence (right). Scale bars represent 500 µm.
#RNAi is an ancestral #antiviral system that degrades viral RNA, but what about in #cnidarians? @yehumoran.bsky.social &co show that #Nematostella has an siRNA-mediated antiviral response that lacks 2ary amplification & functions as a short-term antiviral mechanism @plosbiology.org 🧪 plos.io/3N192OD
Proud moment for City: We’ve been named to BioSpace’s NextGen Class of 2026, recognizing top up-and-coming #lifescience companies in North America. We’re grateful for the recognition and proud of our team pushing innovative #RNAi therapeutics. www.biospace.com/nextgen
dsRNA injection to N. vectensis zygotes triggers mild and transient gene knockdown. Top: Schematic representation of the dsRNA carrying eGFP sequence used in this study and of the transgene of the actin::eGFP line [40]. Bottom left: Heterozygous actin::eGFP embryos showing dimmer eGFP fluorescence 24 hpi of dsRNA carrying eGFP sequence (left) compared to scrambled eGFP sequence (right). Scale bars represent 500 µm. Bottom right: No difference in eGFP fluorescence of heterozygous actin::eGFP embryos is exhibited 72 hpi of dsRNA carrying eGFP sequence (left) compared to scrambled eGFP sequence (right). Scale bars represent 500 µm.
#RNAi is an ancestral #antiviral system that degrades viral RNA, but what about in #cnidarians? @yehumoran.bsky.social &co show that #Nematostella has an siRNA-mediated antiviral response that lacks 2ary amplification & functions as a short-term antiviral mechanism @plosbiology.org 🧪 plos.io/3N192OD
dsRNA injection to N. vectensis zygotes triggers mild and transient gene knockdown. Top: Schematic representation of the dsRNA carrying eGFP sequence used in this study and of the transgene of the actin::eGFP line [40]. Bottom left: Heterozygous actin::eGFP embryos showing dimmer eGFP fluorescence 24 hpi of dsRNA carrying eGFP sequence (left) compared to scrambled eGFP sequence (right). Scale bars represent 500 µm. Bottom right: No difference in eGFP fluorescence of heterozygous actin::eGFP embryos is exhibited 72 hpi of dsRNA carrying eGFP sequence (left) compared to scrambled eGFP sequence (right). Scale bars represent 500 µm.
#RNAi is an ancestral #antiviral system that degrades viral RNA, but what about in #cnidarians? @yehumoran.bsky.social &co show that #Nematostella has an siRNA-mediated antiviral response that lacks 2ary amplification & functions as a short-term antiviral mechanism @plosbiology.org 🧪 plos.io/3N192OD
1/3 🚨New paper from our lab!🔥
Most textbooks will tell you that invertebrates employ #RNAi as antiviral mechanism. Yet, do 🪸🪼 actually do it? Well, the answer is complicated. We show that in #Nematostella dsRNA induces RNAi 🧵
journals.plos.org/plosbiology/...
Over the past few weeks, TRAMA students have been working in the @geneticsub.bsky.social laboratory with the C. elegans model, exploring how mutations, #RNAi, and genetic editing with #CRISPR work.
📷 Image of this year’s course students
New research in #RESInsectMolecBio
Kr-h1 is vital for #vitellogenesis in two ladybird beetle species
doi.org/10.1111/imb.70022
#Henosepilachna #RNAi #Krh1
@sassanasgari.bsky.social @gulianusslab.bsky.social @wileyeco.bsky.social
FDA approval, Breakthrough Therapy status and an early Alzheimer’s trial reshape Arrowhead Pharmaceuticals’ outlook.
longevity.technology/news/arrowhe...
#longevity #biotech #RNAi #PharmaInnovation #HealthcareInvesting #BiotechStocks #DrugDiscovery #PrecisionMedicine #FDAApproval
A seminar room filled with students and researchers seated and listening to a scientific talk. A speaker stands at the front of the room beside a projected presentation slide.
Many thanks to Peter Brodersen (University of Copenhagen) for an excellent talk on “A proxy #RNAi pathway for sensing pathogenic cytoplasmic double-stranded RNA in #plants.” It was a pleasure to have you with us!
Thanks as well to @claudiakohler11.bsky.social for hosting the talk.
«Ha estat un èxit sense precedents, una oportunitat única per a molts dels nostres alumnes, doctorands, investigadors i professors, que han pogut interactuar amb el professor Mello i compartir els seus coneixements i recomanacions (...)» diu el degà Dr. Trilla sobre la visita.
#NobelPrize #RNAi
SanegeneBio and Eli Lilly Unite in Groundbreaking RNAi Research Collaboration #USA #Boston #Lilly #RNAi #SanegeneBio
📢 New publication 'MicroRNA-Induced Gene Silencing ( #MIGS): A Tool for Multi-Gene Silencing and Targeting Viruses in Plants' by Marie-Emilie Gauthier et al. in Plant Biotechnology Journal 🧬🧪
#RNAi #GeneSilencing
doi.org/10.1111/pbi....
Joined University of Gothenburg as a Principal Investigator (PI). With that I begin an independent journey in #RNAthereapeutics and #extracellularvesicles
#Exosomes
#Lipidnanopartivles
#RNA
#mRNA
#RNAi
#siRNA
I’m attending #ASHG2025 in Boston this week! Excited to connect with researchers and innovators in genetics, drug target identification, and clinical development. I’ll be here until Saturday — let’s meet and explore collaboration opportunities!
#Genomics #DrugDiscovery #RNAi #siRNA
#RNAi is redefining genetic medicine 🧬💉 Discover emerging applications 👉 www.marketresearchfuture.com/reports/rnai...
