Figure 1 Hematoxylin andeosin–stainedrenal biopsy(original magnification ×40) of the patient showingtubulointerstitial nephritis, characterized by a mononuclear inflammatory infiltrate with clusters ofmacrophages containing round intracytoplasmic structures (highlighted by the black circle). The Grocott-stained specimen (see Supplementary Figure S1) revealed intracytoplasmic round structures consistent with Histoplasma capsulatum yeasts. These histologic features supported the diagnosis of interstitial nephritis by Histoplasma spp. (see Supplementary Figure S1 for the differential diagnosis discussion).
Supplementary Figure S1. Grocott-stained specimen demonstrating intracytoplasmic round structures consistent with Histoplasma capsulatum yeasts (indicated by the red arrow). The differential diagnosis with other fungi (such as Cryptococcus, Candida, Blastomyces, and Paracoccidioides) and other intracellular pathogens (such as Toxoplasma, Leishmania, and Trypanosoma) was made based on the following histopathologic features: small size (2–5 μm), round shape, homogeneous intracellular distribution, silver positivity, absence of kinetoplasts, and negative mucicarmine staining—all of which supported the diagnosis of histoplasmosis.
Acute interstitial nephritis from ....histoplasma
www.kidney-international.org/article/S008...
@kidneyint.bsky.social
#NephSky #RenalPath