#RNF213, an IFN-inducible #E3Ligase, regulates B-cell development by degrading #SPIB; its loss disrupts AKT-mTOR signaling and antibody responses, while SPIB deletion or #PIK3C3 inhibition restores function. #HumoralImmunity
#OpenAccess in #STTT: doi.org/10.1038/s413...
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