Latest posts tagged with #STTT on Bluesky
This review summarizes the molecular drivers of #Osteoarthritis and highlights innovative therapeutic strategies, including #GeneTherapy and stem cell interventions, to enhance joint regeneration and improve disease outcomes.
#STTT #OpenAccess: doi.org/10.1038/s413...
The exocyst complex component EXOC6B is a key mediator of fungal-induced IL-33 secretion from pancreatic cancer cells, unraveling a novel mechanism by which the #TumorMycobiome modulates the #ImmuneMicroenvironment. @roswellpark.bsky.social
#STTT #OpenAccess: doi.org/10.1038/s413...
A patient-derived iPSC-derived multi-#Organoid platform enables personalized PK/PD-guided therapy for NF1-mutant #BreastCancer, optimizing drug efficacy while monitoring systemic toxicity in a human-scale model.
#STTT #OpenAccess: doi.org/10.1038/s413...
A bimetallic triple-kill nanobomb system (MnO₂/Co-DA@BiTE/HPT) synergistically enhances BiTE efficacy against #ColorectalCancer by activating the STING pathway via #PhotothermalTherapy, to promote robust #AntiTumor immunity.
#STTT #OpenAccess: doi.org/10.1038/s413...
Phase Ia/Ib #ClinicalTrial shows that mesenchymal stromal cell therapy safely improves liver function and exerts dose-dependent immunomodulation, suggesting a promising regenerative strategy in decompensated #Cirrhosis.
#STTT #OpenAccess: doi.org/10.1038/s413...
A randomized #ClinicalTrial shows that #Allogeneic dental pulp stem cell injections enhance periodontal regeneration and improve clinical outcomes, thereby supporting a safe, minimally invasive stem-cell therapy for #Periodontitis. @pku1898.bsky.social
#STTT #OpenAccess: doi.org/10.1038/s413...
This research reveals that targeting lipid-driven pathways in omental macrophages can overcome immunotherapy resistance in ovarian cancer, offering new biomarkers and therapeutic targets for enhanced patient outcomes.
#STTT #OpenAccess: doi.org/10.1038/s413...
Presenting an #iPSC-derived multi-#Organoid platform for NF1-mutant #BreastCancer that enables personalized PK-PD guided therapy providing a high-fidelity model for optimizing treatment regimens for complex genetic profiles.
#STTT #OpenAccess: doi.org/10.1038/s413...
This #STTT study introduces a bimetallic nanobomb that activates the STING pathway and boosts BiTEs-mediated #PhotothermalTherapy, effectively remodeling the #Immunosuppressive #TumorMicroenvironment in #ColorectalCancer.
#OpenAccess: doi.org/10.1038/s413...
Prenatal prednisone exposure promotes #MASLD in offspring via #GR-HDAC3-mediated #Serpina3c suppression, activating the #Chymase-AngII-AT1R axis to disrupt lipid metabolism, marking #Serpina3c as a critical #TherapeuticTarget.
#STTT #OpenAccess: doi.org/10.1038/s413...
Exogenous #EBNA1 promotes #ImmunotherapyResistance by enhancing #ADAR1 translation via the IGF2BP3/EIF4G1 complex, suppressing #Interferon signaling and #ImmuneResponse in #EBV-associated cancers.
#STTT #OpenAccess: doi.org/10.1038/s413...
Enhancing KLF15 expression in cardiomyocytes via a dCas9VPR-mediated transcriptional activation system prevents pathological remodeling and #Fibrosis, thereby establishing it as a critical regulator and #TherapeuticTarget in #HeartFailure.
#STTT #OpenAccess: doi.org/10.1038/s413...
Scientists reveal PKCη as a driver of #TNBC #metastasis by suppressing Hippo signaling & activating YAP, while a uORF-encoded peptide degrades PKCη, highlighting a novel therapeutic vulnerability in aggressive #BreastCancer.
#OpenAccess in #STTT: doi.org/10.1038/s413...
This #STTT study reveals that cholesterol interacts with the spike protein's palmitoylated C-rich region to enhance #SARSCoV2 docking and fusion, highlighting the interaction as a potent #TherapeuticTarget.
#OpenAccess: doi.org/10.1038/s413...
Researchers show dual-target CD19/CD22 #CARTTherapy plus ASCT achieves durable survival in #TP53-mutated r/r aggressive #BNHL, offering curative potential with consistent long-term safety and paving the way for next-gen #immunotherapies.
#OpenAccess in #STTT: doi.org/10.1038/s413...
Scientists map RNA modifications across #multiomics, revealing how genetic variants & PTMs converge to regulate cell fate & disease, with RMzyme offering a resource to explore RMPs as #biomarkers & therapeutic targets. #AcuteMyeloidLeukemia
#OpenAccess #STTT: doi.org/10.1038/s413...
This study presents BiRDS, a DNA-based miR-22 #nanoplatform that penetrates the #retina via a minimally invasive route, suppresses pathological angiogenesis, remodels vessels, protects neurons, & preserves vision by inhibiting Wnt/β-catenin signaling.
#STTT: doi.org/10.1038/s413...
A randomized, double-blind phase 2b trial shows that #Bofanglutide dose-dependently reduces body weight & improves metabolism in overweight or #Obese Chinese adults, exhibiting a tolerable safety profile. @pku1898.bsky.social
#STTT #OpenAccess: doi.org/10.1038/s413...
This study reveals FUS as a key driver of fibrotic signaling in #IdiopathicPulmonaryFibrosis, with #antisense therapy (ION363) reducing profibrotic gene programs & improving patient-derived lung models, highlighting FUS as a promising therapeutic target.
#STTT: doi.org/10.1038/s413...
This multicenter, randomized, double-blind trial demonstrates that Tongxinluo capsule + standard #Statin therapy increases minimum fibrous cap thickness and reduces lipid arc in #AcuteCoronarySyndrome patients.
#STTT #OpenAccess: doi.org/10.1038/s413...
Researchers combine #TDDFT and docking to design theranostic probes for #AlzheimersDisease, showing aromatic delocalization and IAF tagging enhance optical response and selective binding to BACE1, #ADAM10, and neprilysin.
#OpenAccess in #STTT: doi.org/10.1038/s413...
This study employs immunogenic mapping to validate a #TrivalentVaccine strategy providing broad protection against #Sarbecoviruses, offering a scalable framework for pan-virus immunity and future #Pandemic preparedness.
#STTT #OpenAccess: doi.org/10.1038/s413...
Scientists show #CyclicdiGMP inhibits #breastcancer #metastasis by binding #PSMD3, disrupting PSMD3–TBK1 interaction, and suppressing NF‑κB signaling, positioning PSMD3 as a therapeutic target. #Antimetastatic @tulanemedicine.bsky.social
#OpenAccess #STTT: doi.org/10.1038/s413...
This #STTT study presents a high-resolution #Proteomic atlas of the human brain, revealing a three-module functional framework that governs neural interconnectivity, energy metabolism, and regional specialization.
#OpenAccess: doi.org/10.1038/s413...
This study shows #SARSCoV2 upregulates #CD147, driving extended infection and immune imbalance; #Meplazumab blocks CD147–spike interaction, restores immune balance, and mitigates severe #COVID19, highlighting CD147 as a therapeutic target.
#OpenAccess #STTT: doi.org/10.1038/s413...
Findings from the randomized ATTENTION #ClinicalTrial demonstrate that #Aumolertinib plus #Apatinib significantly improves progression-free survival with manageable safety in treatment-naïve, #EGFR-mutant advanced #NSCLC.
#STTT #OpenAccess: doi.org/10.1038/s413...
Researchers identify #DKK3 as a driver of radiation-induced #SkinFibrosis, where keratinocyte DKK3 promotes ROS, TGF-β/Wnt signaling, and M2 #MacrophagePolarization; DKK3 deficiency reduces dermal hyperplasia and fibrosis. @dkfz.bsky.social @umich.edu
#STTT: doi.org/10.1038/s413...
An integrin αvβ3 targeting programmed delivery platform encapsulating Ce6 and BRD4 degrader ARV-825 mitigates CCL5-induced #PhotodynamicTherapy resistance and enhances anti-tumor immunity through #Epigenetic modulation.
#STTT #OpenAccess: doi.org/10.1038/s413...
CXCR4hi #CARTcells boost #TumorTracking, #BoneMarrow homing, and persistence, enhancing #Antitumor activity; early trial data in B cell malignancies show multiple complete responses, supporting #CXCR4 modification.
#OpenAccess in #STTT: doi.org/10.1038/s413...
This #STTT study shows that #Osimertinib disrupts the MYLK4–CDKAL1 interaction, inhibits pT43-CDKAL1 phosphorylation, and CDKAL1-dependent SALL2 translation to inhibit #CancerStemness & #Chemoresistance in #Rhabdomyosarcoma.
#OpenAccess: doi.org/10.1038/s413...
