#Senescent

@ewingt-phd.bsky.social

2 months ago

Clearing the Brain of Aging Cells Could Aid Epilepsy and Reduce Seizures - School of Medicine - Georgetown New research shows that temporal lobe epilepsy can be treated in mice by either genetically or pharmaceutically eradicating the aging cells, thereby improving memory and reducing seizures as well as p...

Researchers @georgetownuni.bsky.social link #epilepsy & #seizures to #senescent cells

medicine.georgetown.edu/news-release...

Temporal lobe epilepsy:

— affects 40% of pts w/ epilepsy
— 5-fold more senescent cells in pts brain tissue
— in mouse model, clearing senescent cells help

#science 🧪

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Hellen C. Greenblatt

@hellengreenblat.bsky.social

5 months ago

Targeting immunosenesence promotes clearance of senescent cells - Immunity & Ageing Known as immunosenescence, the major dysregulation of the immune system with age is associated with poor vaccination efficacy, and increased susceptibility to infections, age-related pathologies, and neoplasms, with incidences exacerbated with age. Cellular senescence is a crucial process that puts cells in an irreversible cell-cycle arrest which prevents damaged or stressed cells from uncontrolled propagation and eventually potential malignancy. Paradoxically, senescence also contributes to the occurrence of cancer and increases the risk of metastasis through different secretory mediators. Altogether, the recent use of senotherapy to eliminate senescent cells has been shown to delay tumorigenesis, attenuate age-related deterioration of organs, and promote healthy aging. Interestingly, immune cells have been shown to specifically interact with, and kill senescent cells, thus opening new opportunities for the development of specific therapeutic strategies similar to immunotherapy in cancer. Through its detrimental impact on the immune system, immunosenescence is also leading to the accumulation of senescent cells with age thus further contributing to the occurrence and worsening of multiple age-related pathologies such as cancer. Understanding the molecular and cellular events occurring during the aging process, and triggering immunosenescence as well as the mechanisms by which senescent cells escape immune surveillance would help to improve immune responses to senescent cells and their clearance. In this review, we highlight how senescent cells interact with immune cells, and how immunosenescence-associated phenotypical and functional deregulation hinder the ability of immune cells to clear senescent cells. We further characterize strategies aimed at promoting the clearance of senescent cells by the immune system.

Chronic #SASP production→ ↑ #inflammation. Accumulation of #senescent cells→ ↑ cancer and other age-associated pathologies. Targeting and clearance of senescent cells ↆ pathologies. bit.ly/46Sbu1r

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FEBS Letters

@febsletters.bsky.social

7 months ago

🔔 Our August issue is online! Issue 15 features:

🖊️ Review: Spatial positioning of #senescent cells in development, healing, and #aging
🐟 Editor's Choice: Social context of #HeatStress and #MutagenStress in zebrafish

➡️ bit.ly/45iS5FW

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Dr. Todd Ewing PhD.

@ewingt-phd.bsky.social

9 months ago

Identification of gingerenone A as a novel senolytic compound Senescent cells accumulate with aging and have been shown to contribute to age-associated diseases and organ dysfunction. Eliminating senescent cells with senolytic drugs has been shown to improve age...

Including #ginger #spice in your diet may help fight #senescent cells & #aging

journals.plos.org/plosone/arti...

NIH Aging researchers study laboratory samples of senescent human cells

I generally include ginger with other anti-aging spices in my morning smoothies

#science #healthy #lifestyle

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FEBS Letters

@febsletters.bsky.social

11 months ago

#Senescence as #barrier and #conductor: Dworak et al. review evidence on how spatial organization of #senescent cells contributes to separating tissues and #secretion of #signaling factors in #development, #healing and #aging.

➡️ doi.org/10.1002/1873-3468.70037

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Nature Reviews Cancer

@natrevcancer.nature.com

1 year ago

#ResearchHighlight 🚨

The #PROTAC 753b, which targets BCL-xL and BCL-2 to the E3 ligase VHL can remove #senescent cells specifically from the liver of mice, reducing the progression of chronic metabolic liver disease to liver cancer.
#senolytics @uthealthbarshop.bsky.social‬

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Dr. Todd Ewing PhD.

@ewingt-phd.bsky.social

1 year ago

Unveiling the cell-type-specific landscape of cellular senescence through single-cell transcriptomics using SenePy - Nature Communications Senescent cells accumulate in tissues with aging and disease but are difficult to detect due to distinct cell-type-specific senescence phenotypes. Here, the authors present the SenePy algorithm to ide...

#UIC researchers unveil single-cell transcriptome identification of #senescent cells

www.nature.com/articles/s41...

— skin hair follicle cells had highest % SCs in patients aged 48–58 !!
— lung pneumocytes had next highest % SCs in patients aged 68–77
— SCs mostly found in clusters in tissues!

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Daniel Hoffmann 🌼

@danielhoffmann1.bsky.social

1 year ago

Anti-ageing jabs – they can rejuvenate mice, but will they work on humans? | Ageing | The Guardian Senescent cells power the body’s ageing process, and scientists are developing treatments to annihilate them

Killing #senescent cells (damaged cells that don't die) rejuvenates mice spectacularly. Now a study with fast #ageing childhood cancer survivors tests this in humans. www.theguardian.com/science/2025/feb/08/anti...

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Daniel Hoffmann 🌼

@danielhoffmann1.bsky.social

1 year ago

Paradoxical link between senescent cell state and liver cancer resolved DNA damage caused by a high-fat diet can increase the risk of tumour formation in the liver.

Prolonged use of energy rich "Western" diet can (in mice) revive #senescent #liver cells to #cancer cells. www.nature.com/articles/d41...

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Prof Claire Hills

@chillslincoln79.bsky.social

1 year ago

Mitochondrial fatty acid oxidation drives senescence Nuclear DNA damage activates fatty acid–fueled mitochondrial energy metabolism to induce cellular senescence, a hallmark of aging.

Mitochondrial fatty acid oxidation drives senescence 👩‍🔬🧪🔬🥼. #ageing #senescence #mitochondria #senescent 👇👇👇

www.science.org/doi/10.1126/...

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Prof Claire Hills

@chillslincoln79.bsky.social

1 year ago

Emerging insights in senescence: pathways from preclinical models to therapeutic innovations - npj Aging npj Aging - Emerging insights in senescence: pathways from preclinical models to therapeutic innovations

Emerging insights in senescence: pathways from preclinical models to therapeutic innovations 👩‍🔬🧪🔬🥼👨‍🔬 #senescence #SASP #ageing #inflammation #NephSky #CardioSky #Senescent

Full details 👇 ✨️

www.nature.com/articles/s41...

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Prof Claire Hills

@chillslincoln79.bsky.social

1 year ago

Senescent Cell Depletion Alleviates Obesity-related Metabolic and Cardiac Disorders Obesity is a major contributor to metabolic and cardiovascular disease. Although senescent cells have been shown to accumulate in adipose tissue, the …

New study reports that Senescent Cell Depletion Alleviates Obesity-related Metabolic and Cardiac Disorders in mice fed an obesogenic diet 🐭👩‍🔬🥼

#Senescence #ageing #metabolicconditions #CardiacSky #NephSky #Senescent

Original paper in link 👇

www.sciencedirect.com/science/arti...

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Prof Claire Hills

@chillslincoln79.bsky.social

1 year ago

Today is #WorldDiabetesDay2024. People with diabetes are at an increased risk of #kidneydisease. Our #DiabetesUK funded #PhD student Paige Phillips is investigating the role of #senescent cells in the onset & progression of kidney injury. Want to know more . Take a look at her lovely infographic 👇

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Tali

@talius2.bsky.social

1 year ago

#Drugs that Kill '#Zombie' #Cells may Benefit #Some Older #Women, but not all

Researchers found that senolytic drugs may benefit older women with many #senescent cells, but are not a universal remedy, as per a new findings, published in Nature Medicine. scitechupdates.com/d...