#Signalling

The Journal of Physiology

@jphysiol.bsky.social

23 hours ago

Rui Zhou and colleagues observed that methionine adenosyl-transferase 2A promotes #placental angiogenesis by regulating VEGF-A translation via the mTORC1 #signalling pathway 🔬🚦

📜 Read the #Research here:
physoc.onlinelibrary.wiley.com/doi/10.1113/...

RailAdvent

@railadvent.bsky.social

4 days ago

RAIB issues safety digest into near miss in Lincolnshire The Railway Accident Investigation Branch has issued a safety digest into a near miss at a manually-controlled barrier level crossing in Lincolnshire.

RAIB issues safety digest into near miss in Lincolnshire www.railadvent.co.uk/2026/03/raib-issues-safe... #helpston #LevelCrossing #lincolnshire #signalling

Philosophics

@microglyphics.bsky.social

5 days ago

On Footnotes Two consecutive posts on writing. What gives? As a writer, I have a kind of workflow in mind. It differs for fiction and nonfiction, though there are similarities. The main differences are indexes,…

Some academic nonfiction books can benefit from footnotes, citations, and references. That's where I am on my current project.
philosophics.blog/2026/03/09/o...
#books #writing #philosophy #footnotes #details #nonfiction #citations #breadcrumbs #performance #signalling #humility #blog #podcast

RailAdvent

@railadvent.bsky.social

6 days ago

Hitachi Rail secures €481m Metro Line 2 deal with the city of Turin Hitachi Rail has landed a €481.6 million contract to deliver next-generation urban mobility for Turin, with the first section of Metro Line 2 expected by 2033. The agreement covers the “Rebaudengo-Politecnico” segment for InfraTO, reinforcing Hitachi Rail’s status as a leader in fully automated metro systems. The deal breaks down…

Hitachi Rail secures €481m Metro Line 2 deal with the city of Turin www.railadvent.co.uk/2026/03/hitachi-rail-and... #accessibility #cbtc #HitachiRail #italy #metro #signalling

RailAdvent

@railadvent.bsky.social

1 week ago

Major rail upgrades set for Britain’s rail network this Easter Network Rail is reminding passengers to check before travel across the UK this Easter bank holiday as a £75.5 million programme of engineering works gets underway to improve reliability and performance. The largest upgrades form part of a wider £400 million investment in the West Coast Main Line, Europe’s busiest…

Major rail upgrades set for Britain’s rail network this Easter #HarrowAmpWealdstone #LeightonBuzzard #london #LondonEuston #MiltonKeynes #NetworkRail #purley #signalling #wembley

RailAdvent

@railadvent.bsky.social

2 weeks ago

Alstom trains and signalling enter service in India Alstom has brought into operational service trains and ETCS signalling on the Namo Bharat corridor and the Meerut Metro near Delhi in India.

Alstom trains and signalling enter service in India www.railadvent.co.uk/2026/02/alstom-trains-an... #alstom #etcs #india #metro #signalling

RailAdvent

@railadvent.bsky.social

2 weeks ago

East Suffolk Line to Close for three successive Weekends in March East Suffolk Line to close over three weekends in March

East Suffolk Line to Close for three successive Weekends in March www.railadvent.co.uk/2026/02/east-suffolk-lin... #EastSuffolkLine #halesworth #ipswich #LevelCrossing #lowestoft #NetworkRail #signalling #suffolk

Ralf Reski

@reskilab.bsky.social

2 weeks ago

Functional characterisation of Target of Rapamycin (TOR) signalling in Physcomitrella - Plant Cell Reports Key message The evolutionary conserved TOR kinase positively controls growth and development of the moss Physcomitrella, development and function of its chloroplasts, its protein synthesis, and cell-c...

Please check out:
Functional characterisation of Target of Rapamycin (TOR) signalling in #Physcomitrella
We found a remarkable evolutionary conservation of this central #signalling hub, but also specific differences, esp. in RAPTOR.
link.springer.com/article/10.1...

RailAdvent

@railadvent.bsky.social

2 weeks ago

London passengers advised to plan ahead during Easter upgrades Network Rail is reminding passengers travelling on the West Coast Main Line are being urged to plan ahead of travel over Easter due to essential railway upgrades between London Euston and Milton Keynes.

London passengers advised to plan ahead during Easter upgrades www.railadvent.co.uk/2026/02/easter-rail-upgr... #AvantiWestCoast #london #LondonEuston #MiltonKeynes #MiltonKeynesCentral #NationalRail #NetworkRail #signalling

RailAdvent

@railadvent.bsky.social

2 weeks ago

Manchester Piccadilly sees first train following upgrades Track panels being dropped during Piccadilly upgrades February 2026

Manchester Piccadilly sees first train following upgrades www.railadvent.co.uk/2026/02/manchester-picca... #manchester #ManchesterPiccadilly #NetworkRail #signalling

RailAdvent

@railadvent.bsky.social

3 weeks ago

Manchester City and James Arthur fans reminded of railway station closure Transport for Greater Manchester (TfGM) is encouraging passengers to plan journeys in advance and allow plenty of time for travel during a nine-day closure of Piccadilly Station and a weekend of events in the city.

Manchester City and James Arthur fans reminded of railway station closure #disruption #GreaterManchester #manchester #ManchesterPiccadilly #metrolink #NetworkRail #signalling #tram

The Journal of Physiology

@jphysiol.bsky.social

1 month ago

🔬 Call for Papers: Channelopathies in Focus

Focusing on #ionchannel–related diseases, from classical plasma‑membrane #channelopathies to emerging roles of organellar channels, non‑excitable cell physiology, and channel‑dependent #signalling.

📍 🔗 physoc.onlinelibrary.wiley.com/hub/journal/...

RailAdvent

@railadvent.bsky.social

1 month ago

East Suffolk railway line set for upgrade work Rail passengers planning to travel on the East Suffolk Line this spring are being urged to check their journeys in advance, ahead of vital engineering work taking place over several weekends in March.

East Suffolk railway line set for upgrade work www.railadvent.co.uk/2026/02/a-better-journey... #EastSuffolkLine #halesworth #ipswich #lowestoft #march #NetworkRail #saxmundham #signalling #suffolk

Rach Cottle

@rachcottle.bsky.social

1 month ago

Visited Castlemaine A signal box recently. Fascinated by the technology.
#VictorianRailways #RailwayHeritage #Signalling #Castlemaine

RailAdvent

@railadvent.bsky.social

1 month ago

Find out what goes on behind the scenes at a heritage railway The Swanage Railway is holding a Community Weekend in February, when visitors can get the rare chance to find out what goes on behind the scenes.

Ticket Inspector Experience www.railadvent.co.uk/2026/02/find-out-what-go... #CorfeCastle #dorset #norden #signalling #swanage #SwanageRailway

RailAdvent

@railadvent.bsky.social

1 month ago

Manchester passengers advised to plan ahead of planned upgrades Passengers are being reminded to check before they travel, as the major £7.9 million upgrade at Manchester Piccadilly is less than two weeks away.

Manchester passengers advised to plan ahead of planned upgrades www.railadvent.co.uk/2026/02/manchester-passe... #disruption #GreaterManchester #ManchesterPiccadilly #NationalRail #NetworkRail #signalling

RailAdvent

@railadvent.bsky.social

1 month ago

Milestone reached for Alstom in Norway Alstom has just installed the European Rail Traffic Management System (ERTMS) into the 100th train as part of Norway’s digital rail transformation.

ERTMS is being installed in all Norway’s passenger trains, locomotives, and track maintenance machines. www.railadvent.co.uk/2026/01/milestone-reache... #alstom #ertms #norway #signalling

RailAdvent

@railadvent.bsky.social

1 month ago

Major disruption to Hampshire and Dorset trains as engineers attend fault Major disruption is affecting trains between Bournemouth and Southampton Central due to a signalling fault. The fault has closed all lines and means that trains may be cancelled or severely delayed. With engineers en route to fix the problem, major disruption is expected until 2 pm today (29th January). CrossCountry…

Major disruption to Hampshire and Dorset trains as engineers attend fault www.railadvent.co.uk/2026/01/major-disruption... #bournemouth #brockenhurst #CrossCountry #disruption #dorset #hampshire #signalling #SouthWesternRailway

RailAdvent

@railadvent.bsky.social

1 month ago

Manchester services to be affected during February half term Next month, Network Rail will be undertaking a £7.9 million upgrade at Manchester Piccadilly.

Manchester services to be affected during February half term www.railadvent.co.uk/2026/01/manchester-servi... #manchester #ManchesterPiccadilly #NetworkRail #signalling

RailAdvent

@railadvent.bsky.social

2 months ago

M6 motorway opens 13 hours early after Cumbria bridge is pushed into place The M6 motorway in Cumbria has reopened 13 hours earlier than scheduled after work to push the new Clifton Bridge was completed. The structure was pushed into place after being built near the site. Work saw the old bridge demolished last weekend during the closure of the motorway. With the…

Work saw the old bridge demolished last weekend during the closure of the motorway. www.railadvent.co.uk/2026/01/m6-motorway-open... #AvantiWestCoast #class_805s #cumbria #NetworkRail #OxenholmeLakeDistrict #signalling #video

The Journal of Physiology

@jphysiol.bsky.social

2 months ago

This paper from Louise Bradshaw (@uniofbath.bsky.social) et al. assessed the independent effects of #carbohydrate and fatty acid availability on exercise-induced skeletal #muscle AMPK activation and downstream #signalling.

📜 physoc.onlinelibrary.wiley.com/doi/10.1113/...

RailAdvent

@railadvent.bsky.social

2 months ago

Carlisle signalling upgrade goes live after 7 day closure As part of a £61 million investment, Network Rail has improved signalling in Carlisle.

Carlisle signalling upgrade goes live after 7 day closure www.railadvent.co.uk/2026/01/carlisle-signall... #carlisle #NetworkRail #siemens #signalling

RailAdvent

@railadvent.bsky.social

2 months ago

Major Transpennine Route Upgrade progress made across Yorkshire During the holidays, the Transpennine Route Upgrade team was working on major improvements at key locations.

Major Transpennine Route Upgrade progress made across Yorkshire www.railadvent.co.uk/2026/01/major-transpenni... #deighton #huddersfield #leeds #mirfield #NetworkRail #signalling #TranspennineRouteUpgrade #york #yorkshire

GLOBAL Visibility aéPiot - by aePiot.ro

@globalvisibility.bsky.social

2 months ago

better-experience.blogspot.com/2026/01/the-...

#MARCO #JOHNSON
allgraph.ro/advanced-sea...
#SIGNALLING OF #THE #TORONTO #SUBWAY
multi-search-tag-explorer.allgraph.ro/advanced-sea...
#MARCEL #LÜSKE
headlines-world.com/advanced-sea...
aepiot.ro

GLOBAL Visibility aéPiot - by aePiot.ro

@globalvisibility.bsky.social

2 months ago

#SIGNALLING #ECONOMICS
multi-search-tag-explorer.headlines-world.com/advanced-sea...
#THOMAS O #HICKS JR
multi-search-tag-explorer.headlines-world.com/advanced-sea...
1946 IN #FILM
multi-search-tag-explorer.aepiot.com/advanced-sea...
headlines-world.com

RailAdvent

@railadvent.bsky.social

2 months ago

Reminder: Work on Clifton Bridge to begin tomorrow Planned engineering works on the West Coast Main Line have included extensive works to Clifton Bridge near Penrith.

Reminder: Work on Clifton Bridge to begin tomorrow www.railadvent.co.uk/2025/12/reminder-work-on... #carlisle #clifton #NationalRail #NetworkRail #oxenholme #penrith #signalling #WestCoastMainLine

Joyce Meiring

@joycemeiri.bsky.social

2 months ago

Bored over the holidays? Give our new preprint on how #microtubule lattice alteration by taxols can regulate #RhoA #signalling via GEF-H1 a read!

Perhaps a new mechanism of action for taxol #chemotherapeutics during interphase.

www.biorxiv.org/content/10.6...

Happy holidays ✨🎄

The French Purine Club

@frenchpurine.bsky.social

2 months ago

📢 Save the date! 3rd European Purine Meeting
🗓️ 1–3 July 2026 |
📍 Bordeaux, France (Univ. Bordeaux, Campus Victoire)

Preceded by the final PRESTO meeting: 30 June–1 July 2026
🌐 Call for Symposia now open: live.eventtia.com/en/european-...

#P1 #P2X#P2Y #ATP #adenosine #purinergic #signalling

RailAdvent

@railadvent.bsky.social

3 months ago

Drivers asked to plan ahead as Cambridgeshire level crossing set for 19-day closure Meldreth Road Level Crossing in Cambridgeshire is to receive a major upgrade this Christmas

Network Rail takes Level crossing safety very seriously. www.railadvent.co.uk/2025/12/drivers-asked-to... #cambridgeshire #christmas #LevelCrossing #meldreth #MeldrethRoad #NetworkRail #shepreth #signalling

RailAdvent

@railadvent.bsky.social

3 months ago

Passengers reminded to plan ahead of West Coast Main Line upgrades Between 24th December and 15th January, the West Coast Main Line will be upgraded, meaning that passengers are advised to check before they travel.

Passengers reminded to plan ahead of West Coast Main Line upgrades www.railadvent.co.uk/2025/12/passengers-remin... #carlisle #HanslopeJunction #NationalRail #NetworkRail #penrith #PrestonLancs #signalling #WestCoastMainLine