Looking forward to working together in the future and further develop #StructuralPhylogenetics in viruses @spyroslytras.bsky.social
#StrPhy26 #StrPhy
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#StructuralPhylogenetics
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Brisbane night
Wrapping up an incredible final day at the APSPM meeting! Huge thanks to the organizers @cpuentelelievre.bsky.social @proteinmechanic.bsky.social Jordan Douglas and all the speakers for the brilliant talks and rich discussions. Beautiful Brisbane!
#StrPhy #StrPhy26 #StructuralPhylogenetics
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Talking about structure-based protein annotations in weid critters (or „Why we shouldn’t say ‘structural homolog’!”). Thanks for having me @strphy.bsky.social #StrPhy #StrPhy26 #StructuralPhylogenetics
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@StrPhy.bsky.social #StrPhy #StrPhy26 #StructuralPhylogenetics APSPM 2026 Meeting, Brisbane: The SMBE Australasian Protein Structural Phylogenetics Meeting
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@StrPhy.bsky.social #StrPhy #StrPhy26 #StructuralPhylogenetics APSPM 2026 Meeting, Brisbane: The SMBE Australasian Protein Structural Phylogenetics Meeting
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Amazing to see all the approaches to structural phylogenetics at APSPM 2026 Meeting, Brisbane: The SMBE Australasian Protein Structural Phylogenetics Meeting @StrPhy.bsky.social #StrPhy #StrPhy26 #StructuralPhylogenetics
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Linking to the APSPM 2026 Meeting going on right now in Brisbane: The SMBE Australasian Protein Structural Phylogenetics Meeting @StrPhy.bsky.social #StrPhy #StrPhy26 #StructuralPhylogenetics
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Amazing talk by @martinsteinegger.bsky.social at the #StructuralPhylogenetics meeting in Brisbane @strphy.bsky.social
The meeting is going to be live for the next 2 days. Excited to see what happens next. #Evolution
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Looking forward to sharing this method as a hands-on workshop in the upcoming meeting
For a full list of workshop we have: biosig.lab.uq.edu.au/strphy26/wor...
#StrPhy26 #StrPhy #StructuralPhylogenetics #Evolution #Brisbane
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Like with the MBE work, DeepRoots introduces a new and much faster way to bootstrap. It achieves this by introducing "Embedding Jitter"—injecting Gaussian noise into the latent space to estimate branch support.
#Phylogenetics #StructuralBiology #Structome #Evolution #StructuralPhylogenetics #StrPhy
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The logic behind this is #EmergentLatentBiology #ELB & is now formalized in our new paper in Curr Op in #StructuralBiology arguing that transformers organize biophysics into a "substrate" where biology becomes easily-decodable. www.sciencedirect.com/science/arti...
#Strphy #StructuralPhylogenetics
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Enter Structome-DeepRoots which uses high-dimensional embeddings from protein language models to see evolutionary "roots" invisible to geometry alone. It was turned into a web app (still has a lot of bugs 😅). 🔗 biosig.lab.uq.edu.au/structome_de...
#StructuralBiology #StructuralPhylogenetics #StrPhy
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Protein structure is more conserved than sequence. Work in 2020 (MBE: academic.oup.com/mbe/article/...), showed 3D data unlocks deeper evolutionary signals. A thought was why not go higher than 3D? 🧵
#Phylogenetics #StructuralBiology #Structome #Evolution #StructuralPhylogenetics #StrPhy
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The program is now live. An excellent global lineup of speakers - AUS, NZ, Korea, India, Laos, UK, Switzerland, France, Finland, Germany, Hungary, Japan, Uruguay, Mexico and USA. Browse abstracts. Just 3 weeks left. Super excited.
#StrPhy26 #Science #Evolution #StrPhy #StructuralPhylogenetics
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New in the #StructuralPhylogenetics special section:
Dixson et al. show that structural and physicochemical features of proteins uncover remote evolutionary relationships and provide a new toolset to revisit mitochondrial enzyme evolution.
@genomebiolevol.bsky.social
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Attending a fascinating talk by
Prof Begona Heras on “Structural insights into the function and inhibition of bacterial virulence proteins. “
Looking for overlaps with methods we are putting together in the Structural Phylogenetics space. #StrPhy #StructuralPhylogenetics @strphy.bsky.social
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We’ve set up a dedicated Bluesky space for structural phylogenetics: @strphy.bsky.social. Follow for community updates.
#StrPhy #StructuralPhylogenetics
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#structuralphylogenetics #strphylo #proteins #evolution
Great example of what protein 3D structures can tell us about evolution and the origin of eukaryotes
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Future work 1) inclusion of custom structure search 2) and I am working on digesting large scale text data via LLMs to offer meaningful text-based insights per query.
Feedback requested:
What would you improve?
#Structome #StructuralPhylogenetics #Science
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Structome-TM preprint now live @ www.biorxiv.org/content/10.1...
@biorxivpreprint.bsky.social
#Science #Structome #StructuralPhylogenetics
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