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Learning about #ATTR amyloidosis @asnc.bsky.social

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New preprint out! 📄 We examine the role of omics analysis in clinical practice and research for Transthyretin Amyloidosis.

Check out the full work here: www.preprints.org/manuscript/2... #RareDisease #ATTR #Genomics #Bioinformatics @ualberta.bsky.social

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Are you looking to know more about the #ATTR #amyloidosis clinical trial landscape?

ARC's Executive Director of Research, Kristen Hsu, will share the latest updates in the next #ARCTalks webinar on January 22 at Noon ET.

Register Today: us02web.zoom.us/webinar/regi...

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Non-Square Image Blur Extensions I recently came across this CodePen demo by Vivi Tseng, which creates the blur extension effect by placing a square div with a blur() beneath the img element and I couldn’t help but think a simpler so...

Just read this great post by @anatudor.bsky.social on non‑square image blur: frontendmasters.com/blog/non-squ...

I thought attr()-tainted <url> would be invalid at computed‑value time per spec? drafts.csswg.org/css-values-5...
What am I missing?

#CSS #attr @bram.us @jamessw.com @una.im

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86 families w/ hereditary #ATTR, cascade genetic screening identified a median of 2 carriers per proband, enabling earlier Dx & Tx. 1/3 of at-risk relatives were untested, showing the need to improve family screening.
https://bit.ly/4paOdOs

#amyloidosis #JACCCardioOnc #CardioOnc #CardioSky

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Structural Homogeneity a Hallmark of Cardiac, Mixed Phenotypes in ATTR ATTR fibrils caused by the T60A TTR gene variant have a single morphology but high compositional homogeneity, according to recent research.

Transthyretin amyloid (#ATTR) fibrils caused by the T60A TTR gene variant, which is associated with a mixed cardiac (#ATTRCM) and neuropathic (#ATTRPN), have a single morphology across patients and tissues. Study in Structure.

Read more: https://bit.ly/3M7nbsM

#RareDisease #Cardiology

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#Whycmr data on vutrisiran in #ATTR #CM #AHA2025
#MedIQAHA25

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QRS Duration May Be a Marker for Survival in Wild-Type ATTR Precise evaluation with routine cardiac diagnosis can help identify patients with wild-type ATTR who have a high risk of mortality.

Precise evaluation with routine cardiac diagnosis can help identify patients with wild-type transthyretin amyloidosis (#ATTR) who have a high risk of mortality.

Read here: https://bit.ly/3XlAWGH

#RareDisease #TransthyretinAmyloidosis #Cardiology

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Finerenone Shows Benefits in Hereditary ATTR Finerenone is effective for kidney protection in hereditary ATTR even in patients with heart failure and preserved ejection fraction.

#Finerenone is effective in kidney protection in patients with hereditary transthyretin amyloidosis (#ATTR), even in patients with #HeartFailure and preserved ejection fraction. Study in @ndt-era.bsky.social

Read here: https://bit.ly/4qSWtUW

#RareDisease #HereditaryTransthyretinAmyloidosis

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The image appears to show a stone structure or monument that is built on a large rock. The building seems to have a square shape and is made of rough-hewn stone. There are trees and green foliage surrounding it, with a clear blue sky above. The structure might be some sort of tower or lookout, given its elevated position.

Image Credits: Wikimedia / Sylius / Public domain

The image appears to show a stone structure or monument that is built on a large rock. The building seems to have a square shape and is made of rough-hewn stone. There are trees and green foliage surrounding it, with a clear blue sky above. The structure might be some sort of tower or lookout, given its elevated position. Image Credits: Wikimedia / Sylius / Public domain

🏙 Area: New York, United States
🏛️ Tourist attraction: Blockhouse No. 1

❓ Are you planning a trip to this town?

➡ Admire the beauty of the sights in New York: visitsights.com/sights/United%20States/N...

#️⃣ #Historic #Sightseeing #Sights #Travel #UnitedStates #NewYork #Fort #Attr...

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ATTR Amyloidosis MAGNITUDE Clinical Trials Temporarily on Hold On October 27, 2025, Intellia Therapeutics temporarily paused enrollment in its MAGNITUDE and MAGNITUDE-2 trials after one participant ...

The #ATTR #amyloidosis MAGNITUDE clinical trials have been temporarily put on hold by @intelliatx and the @US_FDA.

Learn more: arci.org/magnitudehold/

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A graph showing the mean percentage change from baseline in transthyretin (TTR) levels after a single intravenous infusion of nexiguran ziclumeran (nex-z).

A graph showing the mean percentage change from baseline in transthyretin (TTR) levels after a single intravenous infusion of nexiguran ziclumeran (nex-z).

Presented at #ATTR:

Gillmore and colleagues report 24-month results from a phase 1 study of nexiguran ziclumeran, a CRISPR gene-editing approach to treating hereditary transthyretin amyloidosis with polyneuropathy. Full study results: nej.md/46Qhur7

#MedSky #NeuroSky #Genetics

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A real world analysis of tafamidis outcomes still shows the increased mortality in #ATTR #CM

#ESC2025 #CardioSky #MedIQESCCongress

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FAI²R a lu pour vous : ⤵️

📚 Phénotype clinique et pronostic des patients asymptomatiques avec une infiltration cardiaque amyloïde à transthyrétine

💬Résumé par le Docteur Samuel DESHAYES

🔗Lire le résumé : drive.google.com/file/d/1-8g4...

#FAI2R
#ATTR
#FSMR

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The diagnostic odyssey: Challenges and opportunities in transthyretin amyloidosis (ATTR) Navigating the diagnostic journey of transthyretin amyloidosis (ATTR) can be challenging. Learn about the complexities of heart failure, diastolic dysfunction, and the role of echocardiograms in diagn...

Transthyretin amyloidosis (ATTR) is a rarely diagnosed and relentless disease that demands our attention. Despite its severity, #ATTR often slips under the radar, leading to a complex #diagnostic journey, delayed #treatment options and suboptimal standards of #care.

pharmaphorum.com/rd/diagnosti...

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📢 Don't miss our #ARCTALKS webinar next week!

ARC’s Kristen Hsu will share the latest updates on the #ATTR #amyloidosis clinical trial landscape, plus what’s ahead for research in the area.

🗓️ Register now: us02web.zoom.us/webinar/regi...
#ClinicalTrials #RareDisease

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FAI²R a lu pour vous : ⤵️

💬 Résumé par le Docteur Samuel DESHAYES

🔗Lire le résumé : drive.google.com/file/d/13WF-...

#FAI2R
#FSMR
#ATTR

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The image depicts a tall clock tower with a distinctive architectural style. The tower features a clock face, stonework, and a unique crown-like structure at the top. It is set against a clear blue sky with buildings visible in the background, suggesting an urban environment. The tower appears to be under some form of construction or renovation, evidenced by scaffolding around its upper portion.

Image Credits: Wikimedia / Acroterion / CC BY-SA 4.0

The image depicts a tall clock tower with a distinctive architectural style. The tower features a clock face, stonework, and a unique crown-like structure at the top. It is set against a clear blue sky with buildings visible in the background, suggesting an urban environment. The tower appears to be under some form of construction or renovation, evidenced by scaffolding around its upper portion. Image Credits: Wikimedia / Acroterion / CC BY-SA 4.0

🏙 City: Baltimore, United States
🏛️ POI: Emerson Bromo-Seltzer Tower

❓ What's the most breathtaking view you've ever seen while sightseeing?

➡ Create unforgettable memories with these free walking tours in Baltimore: visitsights.com/sightseeing-tours/United...

#️⃣ #Attr...

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📆 📷 June 10 | 12PM ET | #ARCTalks Webinar: #ATTR Cardiac Treatments

Hear Jan Griffin, #amyloidosis cardiologist at the Medical University of South Carolina, discuss how ATTR affects the heart and explore the evolution of treatments for ATTR-CM.

Register Today: us02web.zoom.us/webinar/regi...

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3/11
Remarkable back-to-back! #HeartFailure2025 #LBCT by
Marianna Fontana.

Nex-z CRISPR gene editing based therapy in #ATTRCM. Main paper in @nejm.org www.nejm.org/doi/full/10....

New data by #ATTR type with consistent and durable TTR lowering

#CardioSky #MedSky #Cardiology

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Reliability and validity of the Transthyretin Amyloidosis – Quality of Life (ATTR-QOL) Questionnaire impact scales - Journal of Patient-Reported Outcomes Background The diversity of disease phenotypes associated with transthyretin (ATTR) amyloidosis poses challenges for measurement of health outcomes. The Transthyretin Amyloidosis – Quality of Life (AT...

📢 [New Publication] Evaluating the validity, reliability, and structure of our #ATTR #QOL patient-reported outcome measure!

With strong psychometric support, the ATTR-QOL helps capture the real-life impact of this complex disease.

📄 Read More: jpro.springeropen.com/articles/10....

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Adding #Whycmr to the mix of risk in patients with #ATTR #cardiomyopathy
#ACC25
#CardioSky
#MEDIQACC25
#Cardiology

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Identification of #ATTR #CM using an AI model with ECG and #echofirst by Rohan Khera, et al

#ACC25 #CardioSky #MEDIQACC25 #Cardiology

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Joshua Mitchell presents on the changing demographics and prevalence of #ATTR #CM in the US

#ACC25
#CardioSky
#MEDIQACC25
#Cardiology

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Plasma proteomic profiling in patients with #ATTR #CM as compared to other LVH etiologies

#ACC25
#CardioSky
#MEDIQACC25
#Cardiology

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Martha Grogan, MD, presenting on the many therapies for #ATTR #cardiomyopathy at #ACC25

Starting with a case to see what the audience would do in a typical scenario of ATTR-CM

Audience majority answered tafamidis

#CardioSky
#MEDIQACC25
#Cardiology

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More from Dr. Masri from Day 2 at #ACC.25...

Adding #Whycmr to the mix of risk in patients with #ATTR #cardiomyopathy. @accintouch.bsky.social #CardioSky #Cardiology #MedSky #ACC25

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4/4: And from the session, #HealthDisparities in #hATTR… 3% of U.S. Black patients carry the V122I variant for #ATTR. #ACC.25 #CardioSky #Cardiology @accintouch.bsky.social

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More from #ACC.25. Identification of #ATTR #CM using an AI model with ECG and #echofirst by @rohankhera.bsky.social
et al. #CardioSky #ACC25 #Cardiology

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Joshua Mitchell presents at #ACC.25 on the changing demographics and prevalence of #ATTR #CM in the US. #ACC25 #CardioSky #Cardiology

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