#azole

1 month ago

Top: Subcellular localization of Cap1-GFP in wild-type background (top, tetO-CAP1-GFP/CAP1), Cap1-GFP with C446* (middle, TeO-CAP1C446*-GFP/CAP1) and wild-type Cap1-RFP (bottom, CAP1C446*/TeO-CAP1-RFP) in CAP1/CAP1C446* background. Scale bar, 5 μm. Bottom: Schematic of subcellular localization and transcription activation of CAP1 in wild-type (CAP1/CAP1, left) and CAP1/CAP1C446*. Figure generated with BioRender.

#Azole resistance in #Candida albicans poses a growing threat, and is linked to #StressResponse. @annaselmecki.bsky.social &co show that mutations in the oxidative stress TF Cap1 promote #DrugResistance while exposing a lethal vulnerability at high azole doses @plosbiology.org 🧪 plos.io/4rOrfOz

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PLOS Biology

@plosbiology.org

1 month ago

Top: Subcellular localization of Cap1-GFP in wild-type background (top, tetO-CAP1-GFP/CAP1), Cap1-GFP with C446* (middle, TeO-CAP1C446*-GFP/CAP1) and wild-type Cap1-RFP (bottom, CAP1C446*/TeO-CAP1-RFP) in CAP1/CAP1C446* background. Scale bar, 5 μm. Bottom: Schematic of subcellular localization and transcription activation of CAP1 in wild-type (CAP1/CAP1, left) and CAP1/CAP1C446*. Figure generated with BioRender.

#Azole resistance in #Candida albicans poses a growing threat, and is linked to #StressResponse. @annaselmecki.bsky.social &co show that mutations in the oxidative stress TF Cap1 promote #DrugResistance while exposing a lethal vulnerability at high azole doses @plosbiology.org 🧪 plos.io/4rOrfOz

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PLOS Biology

@plosbiology.org

1 month ago

Top: Subcellular localization of Cap1-GFP in wild-type background (top, tetO-CAP1-GFP/CAP1), Cap1-GFP with C446* (middle, TeO-CAP1C446*-GFP/CAP1) and wild-type Cap1-RFP (bottom, CAP1C446*/TeO-CAP1-RFP) in CAP1/CAP1C446* background. Scale bar, 5 μm. Bottom: Schematic of subcellular localization and transcription activation of CAP1 in wild-type (CAP1/CAP1, left) and CAP1/CAP1C446*. Figure generated with BioRender.

#Azole resistance in #Candida albicans poses a growing threat, and is linked to #StressResponse. @annaselmecki.bsky.social &co show that mutations in the oxidative stress TF Cap1 promote #DrugResistance while exposing a lethal vulnerability at high azole doses @plosbiology.org 🧪 plos.io/4rOrfOz

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Guido Puccetti

@guidopuccetti.bsky.social

3 months ago

A large European diversity panel reveals complex azole fungicide resistance gains of a major wheat pathogen | mBio Sustainable food production requires the management of disease agents attacking crops. Application of antifungal compounds is among the key elements of pathogen containment; however, resistance can ri...

Finally out!
A large European diversity panel reveals complex azole fungicide resistance gains of a major wheat pathogen
journals.asm.org/doi/10.1128/...

A big thanks to @danielcroll.bsky.social & @GabrielScalliet

#azole #DMI #GWAS #fungicide #resistance #zymoseptoria #Europe

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Dominic D. Smith

@dominicdsmith.bsky.social

3 months ago

FUNGICIDE USE, FUNGAL RESISTANCE, AND PUBLIC HEALTH IN THE NETHERLANDS – A ONE-HEALTH SYNTHESIS AND POLICY ROADMAP

Read the full article: acrobat.adobe.com/id/urn:aaid:...

Let’s discuss!

#onehealth #fungicides #publichealth #aspergillus #azole #antifungalresistance #horticulture

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Synlett Journal

@synlettjournal.bsky.social

5 months ago

Josep Cornella & co-workers @cornellab.bsky.social unveil one-step heteroatom exchange🚀 A Ni(0)-catalyzed route converts #isoxazoles & #oxadiazoles into #pyrazoles & 1,2,4-triazoles🧪 A blueprint for rapid #azole scaffold exploration without de novo synthesis🌟
#nickel

👉 buff.ly/BabxqGG

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ECHA - European Chemicals Agency

@echa.europa.eu

1 year ago

For the first time, the #OneHealth
and environment agencies – @efsa.europa.eu, @ecdc.europa.eu, @ema.europa.eu, @eea.europa.eu & @echa.europa.eu- partnered with the
EU Join Research Center to publish findings on #azole #fungicide resistance and its #PublicHealth impact.

🔗 fcld.ly/fungipressre...

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ECHA - European Chemicals Agency

@echa.europa.eu

1 year ago

Resistance to azole fungicides in Aspergillus YouTube video by EFSAchannel

Together with the #OneHealth #EUAgencies and the @ec.europa.eu's Joint Research Centre, we conclude that extensive use of #azole #fungicides, for example in #biocides, can increase the risk of antifungal resistance threatening #publichealth.

Read the news: t.co/aX1v2nHERY

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European Centre for Disease Prevention and Control

@ecdc.europa.eu

1 year ago

Impact of the use of azole fungicides, other than as human medicines, on the development of azole‐resistant Aspergillus spp. The use of azoles in the European Union and European Economic Area (EU/EEA) other than as human medicines has raised concerns about emergence and spread of azole‐resistant Aspergillus species. EU agen...

Tackling #azole resistance requires cross-sectoral collaboration.

The #OneHealth approach brought EU experts from human & veterinary medicine, agriculture & environmental sciences to review evidence, identify factors that promote resistance & propose measures to prevent & control it

bit.ly/3X35QnR

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Spanish open dictionary

@wordmeaningdic.bsky.social

1 year ago

Meaning of #azole Azole is the composite active of a medication antifungal that is used to combat the infections systemic caused by fungi. .. azole

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Spanish open dictionary

@wordmeaningdic.bsky.social

1 year ago

Meaning of #azole I think that the question is to work the Quicksilver. Quicksilver is the same mercury. Element used in artisanal gold mining. It is mu polluting water sources. Azoles are some antifungal, fungal medications... azole

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Dicionário colaborativo Espanhol

@ptsignificadode.bsky.social

1 year ago

Significado de #azole AZOL é o composto ativo de um medicamento antifúngico que é usado para combater infecções sistêmicas causadas por fungos. .. azole

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Diccionario Abierto

@significadode.bsky.social

1 year ago

Significado de #azole Creo que la pregunta es obre el Azogue. Azogue es el mismo mercurio. Elemento que se utiliza en la minería artesanal del oro. Es un elemento mu contaminante de fuentes hídricas. Los Azoles son unos medicamentos antimicóticos, fungicidas... azole

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Dicionário colaborativo Espanhol

@ptsignificadode.bsky.social

1 year ago

Significado de #azole Acho que a questão é trabalhar o Quicksilver. Mercúrio é o mesmo mercúrio. Elemento usado na mineração artesanal de ouro. É fontes de água poluentes mu. Azóis são alguns medicamentos antifúngicos, fungos... azole

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