Latest posts tagged with #GWAS on Bluesky
There is high symptom and genetic overlap across psychiatric conditions. @andrewgrotzinger.bsky.social et al. (2025) explored this using our #GWAS data of over 1 mil cases across 14 conditions. They assessed the genetic architecture and the functional roles of genes across these conditions.
This 5-day course provides a practical introduction to the full #GWAS workflow, guiding participants from study design and data preparation to statistical analysis and interpretation of results.
www.physalia-courses.org/courses-work...
#GWAS #Bioinformatics #Rstats
1/5 Maria Koromina and colleagues investigated genome-wide significant hits that were associated with the likelihood of having BD from our recent #GWAS. They identified from the 64 associated variants 17 that likely played causal roles in bipolar development, implicating 23 different genes.
Last year researchers used our data to publish a paper in Nature Neuroscience mapping genetic variants identified from our previous #bipolar #GWAS to genes and exploring their likely functional effects
Just out.
Genetically determined ancestry is associated with different plaque morphology and molecular features.
In collaboration with @clintomics.bsky.social. @eassociety.bsky.social @umcutrecht.bsky.social #uva #plaque #atherosclerosis #GWAS #GeneSky doi.org/10.1016/j.at...
1/5 We analysed genetic data from over 158,000 people with bipolar disorder and 2.8 million controls, spanning European, East Asian, African American and Latino ancestries — the largest and most diverse BD #GWAS ever conducted.
📄 O'Connell, et al., Biological Psychiatry (2025) 🔗 pubmed.ncbi.nlm.nih.gov/40456304/
#BipolarDisorder #Genomics #MentalHealth #Psychiatry #GWAS
Academician Lusheng Huang team at #JiangxiAgriculturalUniversity unraveled genetic underpinnings of purine content in #pork
🐖🔗 doi.org/10.1016/j.ji...
#QTLs #GWAS #pig #genetic
Genome-wide association study reveals #genomic regions for #nitrogen, #phosphorus and #potassium use efficiency in bread #wheat
🌟🌈☀️ doi.org/10.1016/j.ji...
✏️Jili Xu et al. #PlantScience #NUE #QTL #GWAS
New in #G3journal: Brooke et al. performed #GWAS on the Wild Barley Diversity Collection to identify novel stem rust resistance loci and candidate genes that are effective against a virulent isolate from the Pacific Northwest population. buff.ly/k7nyw4y
Genetic variants identified in adult #GWAS may be relevant to #sleep phenotypes in #adolescents. Great work by Katie Lewis! @sleep-rhul.bsky.social @rhulpsychology.bsky.social
jamanetwork.com/journals/jam...
In a study published in Horticulture Research (Oxford University Press, 2025), researchers from Nanjing Agricultural University and collaborating institutions conducted a large-scale genomic analysis of rooting traits in chrysanthemum.
#Chrysanthemum #GWAS
Details: doi.org/10.1093/hr/u...
I love seeing #gwas folks come around to AI after years & years of bashing it. They could have been part of the solution...
Experimental set-up. 3 to 5-day-old virgin flies were collected and separated into groups of ten by sex, using ten vials of ten flies per sex/genotype/treatment combination. Flies in the exercise-treated group underwent five consecutive days of exercise using the Treadwheel, while animals in the control group were handled the same way, but without the treatment on the Treadwheel. 1 day after completing the exercise treatment, climbing ability of all animals was measured. At this point, the animals were weighed and frozen for metabolite analysis.
James Walts & co use #Drosophila melanogaster to investigate how exercise impacts body composition, specifically, protein content. doi.org/10.1242/bio....
#ExercisePhysiology #Metabolites #TreadWheel #GWAS
The genetics of Black Americans often goes unstudied when looking at Alzheimer's. This #GWAS now available in DSS looked at almost 10,000 participants, using SNPTEST to find genetic variants in people with African ancestry. #genomics
dss.niagads.org/datasets/ng...
A new study in #GENETICS showcases CARLIS, a comprehensive covariate-assisted replicability analysis method, to enhance statistical rigor and biological interpretability while maintaining asymptotic false discovery rate control in #GWAS. buff.ly/9irG1wb
Commentary
Genomics of kidney volumes: one size does not fit all
doi.org/10.1016/j.kint.2025.12.003
Original article: doi.org/10.1016/j.kint.2025.08.038
#NephSky #MedSky #GWAS #kidneydisease
#FruitRes
Genome-wide association studies in 71 citrus varieties reveal 125 loci and 189 genes linked to photosynthesis-related traits.
Details: maxapress.com/article/doi/10.48130/fru...
#CitrusGenomics #Photosynthesis #GWAS #PlantPhysiology
New study finds valvular heart disease, hypertensive heart disease, and endocarditis increase risk of systemic lupus erythematosus, reveals shared genetic links.
doi.org/10.4103/AGIN...
#Lupus #HeartDisease #MendelianRandomization #Genetics #Cardiology #Autoimmune #SLE #GWAS #MedicalResearch
Sharing our pilot genome-wide association study (GWAS) in an Indian CKD population, published in the International Journal of Nephrology.
pubmed.ncbi.nlm.nih.gov/41322097/
#CKD #Nephrology #GWAS #Genomics
2/7
In a #GWAS of >150,000 Omicron cases across four cohorts, we identify 13 genome-wide significant loci, with 8 novel infection-risk signals compared to earlier COVID-19 waves.
@finngen.bsky.social @estbiobank.bsky.social
@massgeneralbrigham.bsky.social
@ssi-dk.bsky.social @bfeenstra.bsky.social
Great to see this work being done. I hope we see much more of it in other disease areas.
#schizophrenia #GWAS #diversity
www.nature.com/articles/s41...
Really honored that our kidney volume genetics paper is accompanied by an editorial commentary in the Feb issue of @kidneyint.bsky.social. Many thanks to @cpattaro.bsky.social & Belen Ponte for the thoughtful perspective, and to all collaborators who made this work possible
#CKD #DeepLearning #GWAS
The commentary introduces the beautiful paper by 👏 @s-monteiromartins.bsky.social @olegborisovphd.bsky.social & the @sfb1453.bsky.social group that present results of #GWAS of kidney volumes estimated through convolutional neural networks #CNN
www.kidney-international.org/article/S008...
#GWAS & #Multiomics reveals a complex bidirectional causality between #Diabetes & #Iridocyclitis, revealing complex bidirectional causality, with insights into shared molecular mechanisms and preventive clinical strategies.
#OpenAccess: doi.org/10.1016/j.ge...
Registrations are still open for the GWAS course starting on Jan 26th!
If you are interested, check it out: www.physalia-courses.org/courses-work...
#GWAS #Bioinformatics #Genomics
Our study on WSMV and TriMV tolerance in wheat wild relatives is out. This work identifies valuable genetic resources for marker-assisted breeding in bread wheat.
Full paper: doi.org/10.3389/fmic...
#Science #PlantPathology #WheatResearch #GWAS #WSMV #TriMV #WheatWildRelative
New Cell Reports study moves GWAS from association to causation, using single-cell multiomics to pinpoint causal variants driving macular degeneration.
#Genomics #GWAS #CausalVariants #PrecisionMed #AMD #complement buff.ly/w7b7CPU
