1/2 In this #JEMLegacy, we revisit a study published in 1963 by Dr. Irwin Lepow that identified C1q, C1r and C1s as subcomponents of the C1 complement complex (rupress.org/jem/article/...).
#immune #complement
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#complement
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Posts tagged #complement
⏳ Last call for trainees & early-career investigators!
Submit an abstract, register early, and apply for a travel award for the 18th Int’l Conference on #ComplementTherapeutics (May 27–June 1, 2026 Sissi, Crete 🇬🇷).
🗓 Deadline: March 15
🔗 aegeanconferences.org/src/App/conf...
#Immunology #Complement
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🎓 Trainees & Young Investigators: Funding is available to attend the 18th Int'l Conference on #Complement #Therapeutics May 27–June 1, 2026 Sissi, Crete 🇬🇷
📢 Submit your abstract and join us!
🔗 www.aegeanconferences.org/src/App/conf...
#ComplementTherapeutics #EarlyCareerResearchers #Immunology
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Funds are still available for Trainee & Young Investigator Travel Awards!
Apply by Feb 28 for the 18th Int'l Conference on #Complement #Therapeutics
📅 05/27/2026 – 06/01/2026
📍 #Sissi, #Crete, #Greece
🏛 #KalimeraKriti Conference Center
Apply here:
aegeanconferences.org/src/App/page...
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Deadline Reminder — Feb 28
Abstracts, Trainee Travel Award applications, and early registration for the 18th Int'l Conference on Complement Therapeutics (May 27–June 1, 2026) in Sissi, Greece close Feb 28.
#Complement #Immunology #ICCT2026 www.aegeanconferences.org/src/App/conf...
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🚨FEBRUARY 2026 ISSUE ONLINE 🚨
🔬#Hyperfibrinolysis and #Complement Activation in #Trauma
🩸#VWF Variants in Type 2 #VonWillebrandDisease
🧠 Serum MPO-DNA #VTE and #Statins in Spontaneous #ICH
🫀Resting Heart Rate and Risk of #VTE
Read at tinyurl.com/yfrtaw7n
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Abstract Submission, Travel Award Applications, and Early Fee Deadline Extended to February 28. Join us at the 18th Int'l Conference on #Complement #Therapeutics www.aegeanconferences.org/src/App/conf... #Crete #Greece May 27-June 1, 2026 #ComplementTherapeutics
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Ever failed to replicate a widely accepted knockout mouse phenotype? You're not alone.
I can finally share our surprising null and negative findings on the complement system receptor C3aR1 in the brain: doi.org/10.1093/brai...
#nullresults #negativeresults #mri #behavior #C3aR1 #complement
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New Cell Reports study moves GWAS from association to causation, using single-cell multiomics to pinpoint causal variants driving macular degeneration.
#Genomics #GWAS #CausalVariants #PrecisionMed #AMD #complement buff.ly/w7b7CPU
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Systemic #complement factors in aging, #AlzheimersDisease and other dementias: a #longitudinal study over 10 years
Xiaofeng Fu, Huimin Cai, Shuiyue Quan...Longfei Jia
link.springer.com/article/10.1...
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REMINDER: Submit your abstract, trainee award application, and online registration to the 18th Int'l Conference on #Complement #Therapeutics held in #Sissi, #Crete, #Greece from May 27 - June 1, 2026 www.aegeanconferences.org/src/App/conf... #complementtherapeutics
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A first-in-class nanobody gene therapy enables sustained, intraocular inhibition of complement C3, significantly suppressing pathological neovascularization. #GeneTherapy #AMD #Complement #Nanobodies #Biotech #VisionScience #TranslationalMedicine buff.ly/JaWxxmB
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C3 lowering in adult APP KI mice rescues synapses and spares cognitive decline
Brijendra Singh, Andre F. Batista, Emma T. Spooner...Cynthia A. Lemere @harvardmed.bsky.social #AlzheimersDisease #complement #amyloid #neuroinflammation
link.springer.com/article/10.1...
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Global C3 lowering in adulthood protects against hippocampal dysfunction and #cognitiveimpairment in aged mice
Andre F. Batista, Jessey Presumey, Brijendra Singh...Cynthia A. Lemere @harvardmed.bsky.social #complement #neurodegeneration
link.springer.com/article/10.1...
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The #complement cascade in #AlzheimersDisease: modern implications of an ancient #immune protagonist
Maria-Tzousi Papavergi, Praveen Bathini, Brijendra Singh & Cynthia A. Lemere @harvardmed.bsky.social
link.springer.com/article/10.1...
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Long #COVID (n=142)→ persistent activation of chronic #inflammation. Including proinflammatory #cytokine signaling, #complement activation, #metabolic dysregulation and immune #exhaustion. Suggestion of link between metabolic dysregulation and inflammation. go.nature.com/48UfU7B
[open access].
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Who controls type-2 immunity?
Turns out fibroblasts do , via a C3–IL-33–ILC2 axis that shapes allergic inflammation in vivo. @atakkatan.bsky.social
Our new work highlighted by @cellreports.bsky.social
#Immunology #StromalBiology #Allergy #Asthma #ILC2 #IL33 #Complement
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New findings reveal IgA nephropathy immune complexes carry a rich complement-protein signature with therapy-responsive markers like FHR1, opening the door to sharper biomarkers and targets. #IgAN #Nephrology #Complement #Biomarkers #Proteomics #MedTwitter buff.ly/GA7gaFq
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Proud of Manchester’s paediatric participation in this game-changing trial published this week in @nejm.org
A golden dawn in renal rare disease
#C3G #IC-MPGN #pegcetacoplan #complement
www.nejm.org/doi/full/10....
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Thrilled to share our work that has indeed *complemented* ongoing research in the lab!!!🙌
#complement #IL33 #fibroblast #ILC2 #airwayallergy
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Our cool new paper depicting fibroblasts more than a scaffold during airway allergy. #Il33 #ILC2 #complement
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New paper alert! We show essential role of #fibroblasts derived #complement C3 in maintaining #Il33-#ILC2 hub during airway #allergy. Congratulations to hard working Ph.D. Students @atakkatan.bsky.social @aishwaryamagesh.bsky.social www.cell.com/cell-reports... @johnshopkinsmmi.bsky.social
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Complementarity: Toward Better Metrics and Optimizing Data Efficiency in LLMs
Roy Siegelmann
Action editor: Gintare Dziugaite
https://openreview.net/forum?id=feAbrMXGMh
#complementarity #complement #generative
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#KashPatel is such a clown that stupidity, it's a gift would be a #complement!!!
#FBI seeks #interviews with #Democrats who urged US #troops to #defy #illegal #orders
www.yahoo.com/news/article...
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Novel Treatment Paradigms: #Complement #Inhibition in Antineutrophil Cytoplasmic Autoantibody Vasculitis
https://doi.org/10.1016/j.ekir.2025.07.015
#KIRReview #ANCA
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Speaker roster for the 2026 #AegeanConference on Complement Therapeutics—taking place next May in Crete—is now available online!
www.aegeanconferences.org/src/App/spea...
#Complement #Neuroscience #Immunology #Therapeutics #AegeanConference2026
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You know plenty that I don't know. #complement
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