Still seeing very low adoption of #flozination and #glipination. Are this cost efective new therapies, like always only very few patients will actually benefit #nephjc
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#flozination
Latest posts tagged with #flozination on Bluesky
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Posts tagged #flozination
cc @christosargyrop.bsky.social
Homer Smith as the original phlorizinator?
#Flozination #NephSky
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⏰2 hours until #NephJC chat
SGLT2i has transformed the world of nephrology, with sustained effects on multiple hard end-points. Do their benefits transcend to transplant patients too? Let’s discuss #flozination in Transplant recipients today, 9PM EST in the #NephJC chat.
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Here is the VA for the INFINITI study of SGLT2i in transplant patients by @glomerican.bsky.social #NephSky #Flozins #Flozination
www.nephjc.com/news/2026/2/8/infiniti-the-visual-abstract
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I would love to believe #flozination helps everything
But this seems too good to be true with such early separation. Some kinda selection bias?
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If age adjusted mortality rates are within a few % of the 2019 levels after:
😍marked ⬇️ in opioid deaths
☠️ "falling by the wayside" in 2020-2022
✌️5 years of :
✔️ advances in cancer immunotherapy
🫀 the #flozination revolution
➡️ the march of Ozempic/GLP1RA
what is causing the excess deaths⁉️
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If age adjusted mortality rates are within a few % of the 2019 levels after:
😍marked ⬇️ in opioid deaths
☠️ "falling by the wayside" in 2020-2022
✌️5 years of :
✔️ advances in cancer immunotherapy
🫀 the #flozination revolution
➡️ the march of Ozempic/GLP1RA
what is causing the excess deaths⁉️
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If age adjusted mortality rates are within a few % of the 2019 levels after:
😍marked ⬇️ in opioid deaths
☠️ "falling by the wayside" in 2020-2022
✌️5 years of :
✔️ advances in cancer immunotherapy
🫀 the #flozination revolution
➡️ the march of Ozempic/GLP1RA
what is causing the excess deaths⁉️
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#Nephjc Christos Argyropoulos from ABQ. Just arrived from #flozination clinic which prevents people from being candidates for phosphate reduction.
No COI
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Haha. Maybe it’s heart failure! We need #flozination @boback.bsky.social
(But jokes apart - agree on pre-test probability of chronic venous insufficiency being high)
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🏥Celebrating 82 years since our hospital exists
2 general conclusions
🍎 Always #flozinate- fun quizz by dr Mugurel Apetrii, mentioning APPLE-CKD 😉
🍎 Adapting Benjamin Franklin’s quote: The only certain things in life are death, taxes and #flozination
#NephSky #MedSky
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Nice ... waiting full results with CONFIDENCE #flozination
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Table 2 Effects of dapagliflozin compared with placebo on diabetes remission and metabolic risk factors. Values are means (SD) unless stated otherwise
After metformin for remission, it’s the turn of #flozination
www.bmj.com/content/388/... in @bmj.com
Compared to caloric restriction alone, slightly more remission with Dapa
Remission defined as coming off Dapa (and metformin) - kinda underwhelming
#MedSky
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Funny - @jama.com IM published two papers simultaneously
Denmark: jamanetwork.com/journals/jam... (Empa = Dapa)
Boston: jamanetwork.com/journals/jam... (also = Cana but use 10 mg Dapa)!
Yes, #Flozination is class effect
@christosargyrop.bsky.social ?
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visual abstract of the study
Figure 1 Bland-Altman plots for creatinine, by glucose concentration. Mean difference and 95% confidence intervals (CIs) are shown by dashed and solid gray lines. If slope is significantly different from 0, bias is instead shown by a regression line in blue. The 95% limits of agreement are shown as solid black lines.
If the urine ACR reduction after #Flozination seems very impressive
make sure it is really true
Glycosuria from SGLT2i = falsely higher urine creatinine by Jaffe = lower Urine ACR
www.kidney-international.org/article/S008... in @kidneyint.bsky.social
#nephSky
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⏰ 1-hour left #nephjc
2022 #TopNephrology was the #flozination second year, this time beyond diabetic kidney disease
🐷 xenotransplantation makes it in the top 10
✨ the joy of getting together in person, after 2 years of COVID was priceless
www.nephjc.com/news/...
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2021 #TopNephrology was the year when 1st place and 5th place were occupied by KDIGO guidelines: 🥇GN guideline, respectively 5th place by BP guidelines
🍎#flozination was now possible in IgAN
🖱️ CLICK trial: lower BP with chlorthalidone in CKD
#NephJC
www.nephjc.com/news/...
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🏆 We remember 2020 as a pandemic year, but not do not forget, that 2020 is the year when nephrology started evidence-based #flozination with DAPA-CKD results
💔 PEXIVAS, ISCHEMIA-CKD, uric acid lowering broke many nephrologists' hearts
www.nephjc.com/news/...
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Not needing to do dialysis.
A few years ago when people talked of screening, early detection and prevention - I used to be leery because our tools were so weak and blunt.
Not any more. #Flozination, #Glipination and much more
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(To complete our takeover of this thread)
Did you see the SWEETSTONE trial results?
bsky.app/profile/swis...
#Flozination
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Iptacopan and Avacopan reacting to the @kireports.bsky.social research letter
(Maybe this will get the immunology glom people to embrace #Flozination over their previous fancy drugs?)
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Our last #NephJC was on #flozination. We discussed the long-term effects of empagliflozin on CKD & revisited the EMPA-KIDNEY study
#NephSky
👉 See the summary blog: www.nephjc.com/news/empa-lo...
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Snapshot of tweets showing conversation re:origins of flozination meme
The origins of #Flozination
Feat. @christosargyrop.bsky.social & @kidneyboy.bsky.social
Heard Aisling McDonough and @juancarlosqvelez.bsky.social refer to SGLT2i as ‘flozins’ and verbification was a natural corollary
#GreatestHits
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This is how you use the neural networks in the EMR. #Flozinator #flozination
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Joel Topf here, I think I'm leaning towards #Flozination but it is too early to call! #NephJC
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A little underdressed for a talk at my hospital @SHLakeland but I’m discussing my favorite topic #flozination and had to wear The Shirt.
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More on #Flozination, associated with 25-30% lower risk of kidney stones
From Boston, propensity score matched
jamanetwork.com/journals/jam... in JAMAIM
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📌Can you think of another drug class that inhibits NHE3 at intestinal levels?
@ChristosArgyrop
could tell us more about #flozination
⁉️ Question: do we know more about glifozins and P? Could they lower the P? #ERA22
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