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Posts tagged #microED

Single-cell structural biology with intracellular electron crystallography

nature.com/articles/s4146…

#StructuralBiology #Crystallography #ElectronDiffraction #3DED #MicroED #XrayCrystallography #CryoEM #FIBSEM #cryoFIB #CLEM #InSitu

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Simplify your plunge freezing workflow. 📉Obtain the consistent vitrification quality required for high-end structural techniques like Single Particle Analysis & Cryo-ET. Learn how with our GraVitri Plunge Cooler Series: zurl.co/p1QLV #SPA #CRYOET #MICROED #CRYOEM

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Using only the first few frames of data from a large number of randomly oriented crystals can improve the recorded ED intensities, the data statistics and the resolution of the final structure #MicroED #DataProcessing #MacromolecularStructure doi.org/10.1107/S205...

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Simplify your plunge freezing workflow. 📉Obtain the consistent vitrification quality required for high-end structural techniques like Single Particle Analysis & Cryo-ET. Learn how with our GraVitri Plunge Cooler Series: zurl.co/p1QLV #SPA #CRYOET #MICROED #CRYOEM

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Exploring the Crystal Structure of Ritonavir Form IV: Understanding Polymorphism in Pharmaceuticals Improved Pharma has published research on the crystal structure of Ritonavir Form IV, enhancing the understanding of pharmaceutical polymorphism and its implications.

Exploring the Crystal Structure of Ritonavir Form IV: Understanding Polymorphism in Pharmaceuticals #USA #West_Lafayette #Improved_Pharma #Ritonavir #MicroED

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Simplify your plunge freezing workflow. 📉Obtain the consistent vitrification quality required for high-end structural techniques like Single Particle Analysis & Cryo-ET. Learn how with our GraVitri Plunge Cooler Series: zurl.co/sarSt #SPA #CRYOET #MICROED #CRYOEM

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最新のMicroEDを学ぶ!創薬と材料研究を加速するセミナー開催のご案内 アクセラレート・バイオが主催するMicroEDセミナーでは、構造解析の最新技術を学びます。参加は無料、英語での発表もあります。

最新のMicroEDを学ぶ!創薬と材料研究を加速するセミナー開催のご案内 #MicroED #アクセラレート・バイオ #ReadCrystal

アクセラレート・バイオが主催するMicroEDセミナーでは、構造解析の最新技術を学びます。参加は無料、英語での発表もあります。

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The SynergyED is such a game changer. It's crazy going from an intractable microcrystalline powder to a structure in under an hour.

#3DED #microED #SynergyED

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最新技術を活用した医薬品開発の可能性が広がるMicroEDユーザーズミーティング 医薬品開発の最前線を切り開くMicroED技術。第1回ユーザーズミーティングが2025年に開催され、期待が高まる。

最新技術を活用した医薬品開発の可能性が広がるMicroEDユーザーズミーティング #東京都 #台東区 #スペラファーマ #MicroED #医薬品開発

医薬品開発の最前線を切り開くMicroED技術。第1回ユーザーズミーティングが2025年に開催され、期待が高まる。

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Single Crystal User Meeting 2025 Join us for the European Single-Crystal User Meeting on October 7-8, 2025, in Neu Isenburg to explore the latest in single crystal diffraction and share your research.

There's never any noise at Rigaku user meetings, just high-quality, well-refined talks. Ba dum tish!

We thank our amazing users and staff in advance for their upcoming contributions listed at the link rigaku.com/products/cry...

#Rigaku #ROD #UserMeeting #Crystallography #SCX #3DED #microED

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日本生薬学会にて発表されるスペラファーマの革新研究成果 スペラファーマ株式会社は、沖縄の海綿由来の新規化合物に関する研究成果を、2025年の日本生薬学会で発表します。

日本生薬学会にて発表されるスペラファーマの革新研究成果 #熊本県 #熊本市 #スペラファーマ #MicroED #日本生薬学会

スペラファーマ株式会社は、沖縄の海綿由来の新規化合物に関する研究成果を、2025年の日本生薬学会で発表します。

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Inorganic <chemistry journal v¡cover art showing the giant statute of a mosrtar and pestle in Balaguer.

Inorganic <chemistry journal v¡cover art showing the giant statute of a mosrtar and pestle in Balaguer.

Our cover art for Inorganic Chemistry is out! Check the paper on #mechanochemsitry of #2Dmaterials and #microED, it is open access thanks to @craiub.bsky.social
@in2ub.bsky.social
@ub.edu
#MyACScover
@pubs.acs.org

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Design of a Zn-based porphyrin MOF biosensor for fluorometric detection of HER2 as a breast cancer biomarker Human epidermal growth factor receptor 2 (HER2) is a critical biomarker for early detection and diagnosis of breast cancer. In this study, we report the synthesis and characterization of a novel zinc-...

This paper by researchers from UAE Uni studies a Zn-MOF designed as a biosensor for HER2, a critical biomarker for early detection of breast cancer.
Always nice to see our kit used in life-saving research and proud Khai could contribute!
pubs.rsc.org/en/content/a...
#SynergyED #3DED #microED #MOF

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July issue @actacrystc.iucr.org The cover article outlines lessons that can be learned from the the profiles and quality of refined MicroED structures #MicroED #electrondiffraction #ED #qualityindicator #bestpractice #cryoEM #Goldstandard #openaccess #IUCr journals.iucr.org/c/issues/202...

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Seed to sub-Å!
We just solved crambin at 0.85Å with #MicroED straight from spontaneous nanocrystals, phased ab-initio from a 5-res helix. Video shows diffraction ➜ ugly start map ➜ beautiful spheres. Preprint: www.biorxiv.org/content/10.1...
#StructuralBiology #CryoEM

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Mechanochemical Synthesis and Electron Crystallography Characterization of van der Waals Lanthanoid 2D Metal–Organic Frameworks Mechanochemical synthesis provides access to clean, effective, and rapid synthesis of 2D van der Waals MOFs [Ln(MeCOO)(PhCOO)2] (1Eu, 2Eu, 2Tb). The method also allows easy access to heterometallic analogue 2LaTb. All samples are obtained as nanosized crystals, and 1Eu has been characterized by electron crystallography (3D-ED). Thus, mechanochemistry and 3D-ED is a winning combination for the clean synthesis of 2D MOFs that can be upscaled to multigram synthesis.

Super happy to share our latest paper on #mechanochemistry and #microED of Van der Waals #2Dmaterials!!
This is really a group effort of many students and collaborators at @imb-cnm-csic.bsky.social
Thanks and congratulations!
@ub.edu
@in2ub.bsky.social
@pubs.acs.org
pubs.acs.org/doi/10.1021/...

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Absolute Asymmetric Synthesis of a Homochiral Polymer from an Achiral Monomer This work demonstrates the absolute asymmetric synthesis of a homochiral polymer from an achiral monomer. Owing to the preservation of symmetry and anisotropy in topochemical reactions, the supramole...

3D Electron Diffraction (aka MicroED) continues to generate high-quality research. We are proud to share this new paper by Dr. Kana M. Sureshan and colleagues on which our own Christian Göb is a co-author.

Check out the paper for more: doi.org/10.1002/anie...

#3DED #microED #SynergyED

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Air-free Transfer | Hummingbird Scientific

Working with air-sensitive materials? Protect them from glovebox to XtaLAB Synergy-ED with the Hummingbird Scientific 1580 Series Air-Free Transfer Sample Holder.
More here: hummingbirdscientific.com/products/air... rigaku.com/products/cry... #SynergyED #HummingBirdScientific #AirFree #3DED #MicroED

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Exfoliation of a metal–organic framework enabled by post-synthetic cleavage of a dipyridyl dianthracene ligand The synthetic tunability and porosity of two-dimensional (2D) metal–organic frameworks (MOFs) renders them a promising class of materials for ultrathin and nanoscale applications. Conductive 2D MOFs a...

Researchers at Yale University have developed a "dianthracene-first" strategy to synthesize macroscopic, mechanically exfoliatable crystals of a 2D zinc MOF. Structural analysis supported by Rigaku instruments #microED #MOF #Xray

pubs.rsc.org/en/content/a...

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#YaleRigaku2025 kicked off with expert talks and workshops on cutting-edge diffraction techniques. The energy on Day 1 has been high. More updates coming soon.
#Crystallography #XrayDiffraction #microED

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What if your TEM could run #microED and solve structures on its own?
Just insert your sample—watch the structure appear.
No human picks. No manual tweaks.
Meet REyes!
doi.org/10.26434/che...
@caltechcce.bsky.social @caltech.edu @uclacb.bsky.social

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A simple cryotransfer method for 3D electron diffraction measurements of highly sensitive samples A simple protocol for transferring highly moisture-sensitive compounds into a transmission electron microscope for 3D electron diffraction measurements is described, with xenon fluorides as a test cas...

Would you like to study air-sensitive samples using 3D electron diffraction?
📢 Check out our latest @japplcryst.iucr.org paper on a cryotransfer method tested on reactive xenon fluorides.
doi.org/10.1107/S160...
#ChemSky #3DED #microED #Crystallography

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So true, a lot of detail is swept under the carpet, and assumed away. Far too many are treating ED as though its a fully understood subject.
Still so much to discover
#3DED #MicroED
I’ll save my rant about why MicroED is a terrible terrible name for another time

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Rigaku and Spera Pharma are collaborating to bring electron diffraction into pharma workflows. With their XtaLAB Synergy-ED now fully commissioned, Spera offers ED-based services. We're proud to support their leadership. Read in the comments!

#Rigaku #SperaPharma #ElectronDiffraction #3DED #MicroED

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MicroEDプラットフォームの革新:新薬開発から材料研究までの挑戦 MicroEDは新薬開発や材料研究において重要な役割を果たす革新的な解析技術です。その適用事例を紹介します。

MicroEDプラットフォームの革新:新薬開発から材料研究までの挑戦 #MicroED #新薬開発 #ReadCrystal

MicroEDは新薬開発や材料研究において重要な役割を果たす革新的な解析技術です。その適用事例を紹介します。

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Ever wanted to better understand site occupancies in materials like ZSM-5?
Whenever you aren't sure of the composition, EDS is a tool for XtaLAB Synergy-ED that does just that!
See our website for more details on EDS rigaku.com/products/cry...
#MicroED #3DED #EDS #Crystallography

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Jessica Burch presenting the latest results from the XtaLAB Synergy-ED at this weeks joint Rigaku - Georgia Institute of Technology Symposium and workshop. #microED #crystallography

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This work was done in close collaboration with C.Sañudo (key for solving #microED structures -a lot of- ), C.Santiago (the #microED boss 😀), E.Burzuri (Electron transport) as well as S. Gullace (Raman) and E.Resines-Urien
@tcdd-quimicaub.bsky.social @cnb-csic.bsky.social @ifimacuam.bsky.social

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Conversion of Flexible Spin Crossover Metal–Organic Frameworks Macrocrystals to Nanocrystals Using Ultrasound Energy: A Study on Structural Integrity by MicroED and Charge‐Transport Properties In this work, nanocrystals of a robust switchable SCO-MOF are successfully synthesized using a sonication strategy. Microcrystal Electron Diffraction (MicroED) confirmed the preservation of structura...

Want to learn how to convert switchable #MOFs in #nanocrystals while keeping their properties? 👇
Deep #microED and electron transport⚡️study
Congrats to A.Martinez for making this happen 👏
@ecsanudo.bsky.social E.Burzurí C.Santiago @imdeananociencia.bsky.social
onlinelibrary.wiley.com/doi/10.1002/...

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Comprehensive microcrystal electron diffraction sample preparation for cryo-EM - Nature Protocols We present a protocol for preparing microcrystal samples for cryo-EM diffraction imaging, including room temperature solid-state small molecules and soluble and membrane protein crystals.

Super happy to share our latest work! A detailed protocol for #MicroED sample prep available @NatureProtocols! It covers #FIB, grid making, sample handling, #CryoFLM, and more! Hope it helps!

www.nature.com/articles/s41...

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