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Gut Microbiome and Bile Acid Interactions Cholangiocarcinoma (CCA) is a rare but highly malignant carcinoma of bile duct epithelial cells with a poor prognosis. The major risk factors of CCA carcinogenesis and progression are cholestatic live...

#LegacyContent: Gut Microbiome and Bile Acid Interactions: Mechanistic Implications for #Cholangiocarcinoma Development, Immune Resistance, and Therapy.

Free in the #OpenArchive: ajp.amjpathol.org/article/S000...

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Concordance of Whole-Genome Long-Read Sequencing with Standard Clinical Testing for Prader-Willi and Angelman Syndromes Current clinical testing approaches for individuals with suspected imprinting disorders are complex, often requiring multiple tests performed in a stepwise manner to make a precise molecular diagnosis...

#LegacyContent: Concordance of Whole-Genome Long-Read Sequencing with Standard Clinical Testing for Prader-Willi and Angelman Syndromes.

Free in the #OpenArchive: www.jmdjournal.org/article/S152...

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Predicting Consanguinity Rates from Exome Sequencing Data in the Lebanese Population Consanguinity, prevalent in certain populations because of cultural and social factors, significantly increases the risk of genetic autosomal recessive disorders. In Lebanon, consanguineous marriages ...

#LegacyContent: Predicting Consanguinity Rates from Exome Sequencing Data in the Lebanese Population.

Free in the #OpenArchive: www.jmdjournal.org/article/S152...

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forever fluorinated Polyfluorinated alkyl substances (PFAS) aka "forever chemicals" have been in the news a lot, as they are now being found just about everywhere including in animal and human tissues. So it was about time to do a feature about them, which is out now: **Forever problems** Current Biology Volume 35, Issue 4, 24 February 2025, Pages R125-R127 FREE access to full text and PDF download See also my Mastodon thread where I highlighted all CB features of 2025. The thread for 2024 is here . Firefighting foams containing PFAS have been used for decades. In locations with regular fire drills, the substances have accumulated in the environment. (Photo: Senior Airman Brett Clashman, US Air Force/Wikimedia Commons.) NB I love this photo to bits, but the things I learned about PFAS pollution produced by regular firefighting drills were downright scary. I mean I get that you make exceptions for its use in life or death situations, but apparently some places such as airports have saturated their environment by spreading the stuff every week in their drills.

last year's feature on #PFAS #ForeverChemicals now in the #OpenArchive and sadly still relevant #FreeAccess for all.
proseandpassion.blogspot.com/2025/02/forever-fluorina... #science #environment #pollution

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Programmed Death Ligand-1 in Melanoma and Extracellular Vesicles Promotes Local and Regional Immune Suppression through M2-like Macrophage Polarization Tumor-associated macrophages (TAMs) play dual roles (both pro- and antitumor) in tumor progression. TAMs induce programmed death ligand-1 (PD-L1) expression in cancer cells. However, the regulatory ef...

#LegacyContent: Programmed Death Ligand-1 in Melanoma and Extracellular Vesicles Promotes Local and Regional Immune Suppression through M2-like Macrophage Polarization.

#OpenArchive: ajp.amjpathol.org/article/S000...

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#LegacyContent: Multi-Class Segmentation Network Based on Tumor Tissue in Endometrial Cancer Pathology Images: ECMTrans-net

Free in the #OpenArchive: ajp.amjpathol.org/article/S0002-9440(24)00...

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Analytical and Clinical Validation of the Plasma-Based Guardant360 CDx Test for Assessing HER2 (ERBB2) Mutation Status in Patients with Non–Small-Cell Lung Cancer for Treatment with Trastuzumab Deruxt... This study demonstrates the analytical and clinical validity of the approved (United States and Japan) plasma-based Guardant360 companion diagnostic (CDx) test for selecting patients with human epider...

#LegacyContent: Analytical and Clinical Validation of the Plasma-Based Guardant360 CDx Test for Assessing HER2 (ERBB2) Mutation Status in Patients with Non–Small-Cell Lung Cancer for Treatment with Trastuzumab Deruxtecan in DESTINY-Lung01/02.

#OpenArchive: www.jmdjournal.org/article/S152...

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Validation and Performance of Quantitative BRCA1 and RAD51C Promoter Hypermethylation Testing in Breast and Ovarian Cancers Poly (adenosine diphosphate-ribose) polymerase (PARP) inhibitors represent a significant advancement in the treatment of epithelial ovarian cancer, triple-negative breast cancer, pancreatic cancer, an...

#LegacyContent: Validation and Performance of Quantitative BRCA1 and RAD51C Promoter Hypermethylation Testing in Breast and Ovarian Cancers.

#OpenArchive: www.jmdjournal.org/article/S152...

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Sphingosine Kinase 2 Controls the Aggressive Phenotype of Oral Squamous Cell Carcinoma by Regulating miR-205 and miR-296 through p53 Alterations in miRNAs, p53, and sphingolipid metabolism are associated with head and neck squamous cell carcinoma (HNSCC). However, the role of sphingosine kinase (SK)-2, an enzyme crucial for sphingo...

#LegacyContent: Sphingosine Kinase 2 Controls the Aggressive Phenotype of Oral Squamous Cell Carcinoma by Regulating miR-205 and miR-296 through p53. Authors from University of São Paulo.

Free in the #OpenArchive: ajp.amjpathol.org/article/S000...

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#LegacyContent: Single-Cell Advances in Investigating and Understanding Chronic Kidney Disease and Diabetic Kidney Disease

Free in the #OpenArchive: ajp.amjpathol.org/article/S0002-9440(24)00...

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#LegacyContent: SARCP, a Clinical Next-Generation Sequencing Assay for the Detection of Gene Fusions in Sarcomas.

Free in the #OpenArchive: www.jmdjournal.org/article/S1525-1578(24)00...

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#LegacyContent: The Kidney Precision Medicine Project and Single-Cell Biology of the Injured Proximal Tubule

Free in the #OpenArchive: ajp.amjpathol.org/article/S0002-9440(24)00...

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#LegacyContent: Considerations for Severe Acute Respiratory Syndrome Coronavirus 2 Genomic Surveillance: A Joint Consensus Recommendation of AMP and APHL.

Free in the #OpenArchive: www.jmdjournal.org/article/S1525-1578(24)00...

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tiny survivors Tardigrades (water bears) have often appeared in my writing as an example of remarkable resilience under extreme conditions. Our shared history goes back to the German edition of Life on the Edge, which came out in 1997, and from there they spread into the pages of Astrobiology. I just noticed I even created a tag for them back in the 00s when they took up space travel. Since then, they even landed on the Moon. Surprisingly, however, I haven't had a full feature dedicated to them. As there have been several new developments in the field of tardigrade evolution, ecology and resilience accumulating in the last few months, and as I often use the first feature of the new year to describe "fantastic species", I felt the time had come to put the spotlight on tardigrades. In the process, I learned that apart from individual specimens surviving the most horrendous physical conditions one can imagine, their lineage has also survived the last three of the five big mass extinctions. Hence it isn't even a an exaggeration to call the feature: **Ultimate survivors** Current Biology Volume 35, Issue 1, 6 January 2025, Pages R1-R3 FREE access to full text and PDF download (will become open access one year after publication) See also my Mastodon thread where I highlighted all CB features of 2025. The thread for 2024 is here . Much about the distribution, ecology and physiology of tardigrades remains to be explored. (Photo: Frank Fox/Wikimedia Commons (CC BY-SA 3.0 DE).) Update 7.4.2025: A tardigrade has just been voted Invertebrate of the Year!

Last year's feature about #tardigrades is now in the #OpenArchive. proseandpassion.blogspot.com/2025/01/tiny-survivors.h... #science #ecology #LifeOnTheEdge #astrobiology

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last year's feature about the breakthrough in long-lasting #prophylaxis against #HIV-#AIDS is now in the #openArchive www.cell.com/current-biology/fulltext...
#science #medicine #health #publicHealth

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#LegacyContent: Tailored digital PCR follow-up of rare fusion transcripts after initial detection through RNA-sequencing in hematological malignancies. Authors from @chugrenoblealpes.bsky.social

Free in the #OpenArchive: https://loom.ly/4Yeezok

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#LegacyContent: Glucocorticoid Receptor Signaling Is Critical for Mouse Corneal Development, Inhibition of Inflammatory Response, and Neovascularization of the Cornea.

Free in the #OpenArchive: ajp.amjpathol.org/article/S0002-9440(24)00...

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#LegacyContent: Artificial Intelligence-Based Histopathological Subtyping of High-Grade Serous #OvarianCancer.

Free in the #OpenArchive: ajp.amjpathol.org/article/S0002-9440(24)00...

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#LegacyContent: Characterization of Reference Materials for DPYD: A GeT-RM Collaborative Project. Authors from @research.childrensmercy.org @mayoclinic.org

Free in the #OpenArchive: https://loom.ly/tObQjC0

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#ArticleinPress: Comparative Analysis of Gene Expression Analysis Methods for RNA In Situ Hybridization Images. Authors from @helsinki.fi

Free in the #OpenArchive: www.jmdjournal.org/article/S1525-1578(24)00...

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#LegacyContent: Analytical Validation of an Early Detection Pancreatic Cancer Test Using 5-Hydroxymethylation Signatures. From authors at @clearnotehealth.bsky.social.

#OpenArchive: www.jmdjournal.org/article/S1525-1578(24)00...

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#LegacyContent: Strategic Implementation of #FragileX Carrier Screening in China: A Focused Pilot Study.

Free in the #OpenArchive: www.jmdjournal.org/article/S1525-1578(24)00...

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New month, new #LegacyContent! The full October 2024 issue of @jmdiagn.bsky.social is now free in the #OpenArchive.

Full issue: https://www.jmdjournal.org/issue/S1525-1578(23)X0013-0

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#LegacyContent: Aurora Kinase A Is Overexpressed in Human Retinoblastoma and Correlates with Histopathologic High-Risk Factors

Free in the #OpenArchive: ajp.amjpathol.org/article/S0002-9440(24)00...

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#LegacyContent: A Multiscale Connected UNet for the Segmentation of Lung Cancer Cells in Pathology Sections Stained Using Rapid On-Site Cytopathological Evaluation

Free in the #OpenArchive: ajp.amjpathol.org/article/S0002-9440(24)00...

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#LegacyContent: #DeepLearning for Grading Endometrial Cancer. Authors from Dartmouth and @unileiden.bsky.social.

Free in the #OpenArchive: ajp.amjpathol.org/article/S0002-9440(24)00...

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#LegacyContent: Assessing the risk stratification of breast cancer polygenic risk scores in a Brazilian cohort. Authors from @brynmawrcollege.bsky.social

Free in the #OpenArchive: www.jmdjournal.org/article/S1525-1578(24)00...

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#LegacyContent: Local Tetanus Begins with a Neuromuscular Junction Paralysis around the Site of Tetanus Neurotoxin Release due to Cleavage of the Vesicle-Associated Membrane Protein. @ukdri.ac.uk

#OpenArchive: https://loom.ly/2YOafvc

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Bifidobacterium bifidum Strain BB1 Inhibits Tumor Necrosis Factor-α–Induced Increase in Intestinal Epithelial Tight Junction Permeability via Toll-Like Receptor-2/Toll-Like Receptor-6 Receptor Complex–Dependent Stimulation of Peroxisome Proliferator-Activated Receptor γ and Suppression of NF-κB p65 Bifidobacterium bifidum strain BB1 causes a strain-specific enhancement in intestinal epithelial tight junction (TJ) barrier. Tumor necrosis factor (TNF)-α induces an increase in intestinal epithelial TJ permeability and promotes intestinal inflammation. The major purpose of this study was to delineate the protective effect of BB1 against the TNF-α–induced increase in intestinal TJ permeability and to unravel the intracellular mechanisms involved. TNF-α produces an increase in intestinal epit...

#LegacyContent: Bifidobacterium bifidum Strain BB1 Inhibits Tumor Necrosis Factor-α–Induced Increase in Intestinal Epithelial Tight Junction Permeability via [...] Suppression of NF-κB p65

Free in the #OpenArchive: https://loom.ly/ClBuIpw

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#LegacyContent: Apoptosis Signal-Regulated Kinase-1 Promotes Nucleus Pulposus Cell Senescence and Apoptosis to Regulate Intervertebral Disc Degeneration

Free in the #OpenArchive: ajp.amjpathol.org/article/S0002-9440(24)00...

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