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Pharmacological Modulation of Oxidative Stress, Neuroinflammation, and Synaptic Dysfunction for Precision Neuroprotection in Neurodegenerative Disorders: A Narrative Review - Premier Science BDNF, HO-1 signaling, Multifunctional antioxidant flavonoids, NLRP3 inflammasome inhibition, Nrf2, Precision multitarget neuroprotection

doi.org/10.70389/PJS...

#oxidativestress #neuroinflammation #synapticdysfunction #neuroprotection #neurodegenerative #neurodegenerativedisorders

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BioRxiv Article

[BioRxiv] PKC-dependent MYRF dysregulation links Aβ pathology to oligodendrocyte, myelin and cognitive alterations in Alzheimer's disease

https://doi.org/10.64898/2025.12.09.693299

#neurodegeneration #biorxiv #amyloid #synapticdysfunction #Alzheimers

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BioRxiv Article

[BioRxiv] TREK1 upregulation is an endogenous mechanism delaying cognitive decline in Alzheimer's Disease

https://doi.org/10.1101/2025.10.16.682816

#neurodegeneration #biorxiv #amyloid #amyloidbeta #synapticdysfunction #Alzheimers

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BioRxiv Article

[BioRxiv] Genetic ablation of neuronal mitochondrial calcium uptake halts Alzheimer's disease progression

https://doi.org/10.1101/2023.10.11.561889

#neurodegeneration #biorxiv #Alzheimers #mitochondrialdysfunction #synapticdysfunction

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Neuroimaging-derived biological brain age and its associations with glial reactivity and synaptic dysfunction cerebrospinal fluid biomarkers.

https://pubmed.ncbi.nlm.nih.gov/40221600/

#neurodegeneration #synapticdysfunction #biomarker

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SFRP1 upregulation causes hippocampal synaptic dysfunction and memory impairment.

https://pubmed.ncbi.nlm.nih.gov/40198223/

#neurodegeneration #synapticdysfunction

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