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How to build a testis, cell by cell Engineered pluripotent stem cells form somatic and germ cells that mimic a functional testis

😊 Lovely work in @ScienceMagazine by Hayashi group on building a #testis from stem cells.

📝 Check out this perspective* on how this could one day help us to restore fertility in males 🙏

👉 tinyurl.com/mrx49fjz

The paper can be viewed here 👉 tinyurl.com/3853y5m9

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Somatic sex maintenance in the Drosophila testis. Left: in XY adults, chinmo prevents Zld protein expression, keeping traF off and allowing dsxM to maintain the male fate (blue) while the female pathway is switched off (gray). Right: loss of chinmo leads to the ectopic expression of zld, inducing traF and activating the female developmental program (red) in chromosomally male cells.

Somatic sex maintenance in the Drosophila testis. Left: in XY adults, chinmo prevents Zld protein expression, keeping traF off and allowing dsxM to maintain the male fate (blue) while the female pathway is switched off (gray). Right: loss of chinmo leads to the ectopic expression of zld, inducing traF and activating the female developmental program (red) in chromosomally male cells.

In the #gonad, #sex is not an irrevocable commitment, and requires active maintenance. Artyom Kopp explores a new @plosbiology.org study elucidating the molecular mechanisms that preserve sexual identity in the adult #Drosophila #testis 🧪 Paper: plos.io/4pMT6hq Primer: plos.io/3MRBBxG

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 Somatic sex maintenance in the Drosophila testis. Left: in XY adults, chinmo prevents Zld protein expression, keeping traF off and allowing dsxM to maintain the male fate (blue) while the female pathway is switched off (gray). Right: loss of chinmo leads to the ectopic expression of zld, inducing traF and activating the female developmental program (red) in chromosomally male cells.

Somatic sex maintenance in the Drosophila testis. Left: in XY adults, chinmo prevents Zld protein expression, keeping traF off and allowing dsxM to maintain the male fate (blue) while the female pathway is switched off (gray). Right: loss of chinmo leads to the ectopic expression of zld, inducing traF and activating the female developmental program (red) in chromosomally male cells.

In the #gonad, #sex is not an irrevocable commitment, and requires active maintenance. Artyom Kopp explores a new @plosbiology.org study elucidating the molecular mechanisms that preserve sexual identity in the adult #Drosophila #testis 🧪 Paper: plos.io/4pMT6hq Primer: plos.io/3MRBBxG

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 Somatic sex maintenance in the Drosophila testis. Left: in XY adults, chinmo prevents Zld protein expression, keeping traF off and allowing dsxM to maintain the male fate (blue) while the female pathway is switched off (gray). Right: loss of chinmo leads to the ectopic expression of zld, inducing traF and activating the female developmental program (red) in chromosomally male cells.

Somatic sex maintenance in the Drosophila testis. Left: in XY adults, chinmo prevents Zld protein expression, keeping traF off and allowing dsxM to maintain the male fate (blue) while the female pathway is switched off (gray). Right: loss of chinmo leads to the ectopic expression of zld, inducing traF and activating the female developmental program (red) in chromosomally male cells.

In the #gonad, #sex is not an irrevocable commitment, and requires active maintenance. Artyom Kopp explores a new @plosbiology.org study elucidating the molecular mechanisms that preserve sexual identity in the adult #Drosophila #testis 🧪 Paper: plos.io/4pMT6hq Primer: plos.io/3MRBBxG

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Representative confocal images of a control testis (top row), a testis somatically depleted of chinmo (middle row), and a testis with somatic co-depletion of chinmo and zld (bottom row). Testes are stained for Vasa (gray), Fas3 (green, grayscale), and Tj (magenta).

Representative confocal images of a control testis (top row), a testis somatically depleted of chinmo (middle row), and a testis with somatic co-depletion of chinmo and zld (bottom row). Testes are stained for Vasa (gray), Fas3 (green, grayscale), and Tj (magenta).

How is somatic gonadal #sex fate maintained throughout adulthood? This study identifies a post-transcriptional mechanism involving repression of the TF Zelda by #miRNAs, safeguarding male identity & preventing activation of the female program in #Drosophila #testis @plosbiology.org 🧪 plos.io/4pMT6hq

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Representative confocal images of a control testis (top row), a testis somatically depleted of chinmo (middle row), and a testis with somatic co-depletion of chinmo and zld (bottom row). Testes are stained for Vasa (gray), Fas3 (green, grayscale), and Tj (magenta).

Representative confocal images of a control testis (top row), a testis somatically depleted of chinmo (middle row), and a testis with somatic co-depletion of chinmo and zld (bottom row). Testes are stained for Vasa (gray), Fas3 (green, grayscale), and Tj (magenta).

How is somatic gonadal #sex fate maintained throughout adulthood? This study identifies a post-transcriptional mechanism involving repression of the TF Zelda by #miRNAs, safeguarding male identity & preventing activation of the female program in #Drosophila #testis @plosbiology.org 🧪 plos.io/4pMT6hq

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Representative confocal images of a control testis (top row), a testis somatically depleted of chinmo (middle row), and a testis with somatic co-depletion of chinmo and zld (bottom row). Testes are stained for Vasa (gray), Fas3 (green, grayscale), and Tj (magenta).

Representative confocal images of a control testis (top row), a testis somatically depleted of chinmo (middle row), and a testis with somatic co-depletion of chinmo and zld (bottom row). Testes are stained for Vasa (gray), Fas3 (green, grayscale), and Tj (magenta).

How is somatic gonadal #sex fate maintained throughout adulthood? This study identifies a post-transcriptional mechanism involving repression of the TF Zelda by #miRNAs, safeguarding male identity & preventing activation of the female program in #Drosophila #testis @plosbiology.org 🧪 plos.io/4pMT6hq

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#pecs #fitspiration #bodycheck #bulge #Male #musclecock #muscle #master #Masterbate #AlphaMale #cum #cock #nutsack #bigballs #testis

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Recurrent expansion and rapid evolution of the Drosophilid RNAi pathway in testis Multiple classes of selfish genetic elements, including transposable elements, meiotic drivers, and viruses, are suppressed by small interfering RNAs (siRNAs) that guide RNA interference (RNAi). These...

#RNAi #Drosophila #Testis #Evolution www.biorxiv.org/content/10.1...

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Video

Glittering art in the Jewellery Quarter Birmingham by #artist DeniseBallard-Wyllie ARE in the talented @re_printmakers at the RBSA Gallery, Birmingham 7-18 October
Enjoy creativity, collect unique art for your home
#scienceart #womanartist #testis #affordableart #cells
artistdenisewyllie #buyart

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睪丸 ( #Testis ):
Testis
接收上述賀爾蒙後,
開始啟動精子發生,
並透過睪固酮促進精子的成熟、維持男性第二性徵 ( 如聲音低沉、
體毛增加 )。

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#Bolas #Pelotas #Escroto #Hoden #яечка #тестис #Testis #Testicle #Varle #Pinga #Barrabil #Testicule #όρχις #Zaadbal #Testicolo #Testikolu #testikkel #अंडा #Butt #tèstikul #тестис #testikkel #Balls #Holle #Pack #Butts #Huevos #Testicles #Nutts #Pelotas #Güevos #Cojones #Canicas

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A fantastic talk from Grace about #chemotherapy exposure in the #testis 👏🏼👏🏼 So important for protection of #fertility in #ChildhoodCancer 🎗️

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Lovely talk from @GraceForsyth13 on an in-vivo model for chemotherapy exposure in the #testis. Important work for developing strategies for #FertilityPreservation 👏🏻👏🏻👏🏻

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https://www.sciencedirect.com/science/article/pii/S0032579125003803

https://www.sciencedirect.com/science/article/pii/S0032579125003803

Oral administration of #probiotic LbSNI3 enhances #antioxidant defense mechanisms in the #testis, leading to increased #reproductive index in adult roosters. This effect may be mediated through the #gut-testis axis and could be utilized to improve productivity in livestock industry.

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Gonadal (Ovary and Testis) Volume Calculator - Rad At Hand Free radiology volume calculator for gonads (ovarian/testicular) based on CT, MRI, & US, with separate formulas for testes & ovaries.

Simplify your assessment of #ovarian and #testicular volumes with our #gonadal volume calculator, now equipped with a report generator! Streamlined for efficiency.
#radiology #RadTwitter #ovary #testis #ultrasound #radres #radfellow

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“Anotha one”
#gay #twink #vers #top #bottom #cock #dick #balls #scrotum #testis #testicles

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Have some more testis before I go to sleep :3
#gay #twink #vers #top #bottom #cock #dick #balls #scrotum #testis #testicles

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