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Latest posts tagged with #ABPP on Bluesky

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Posts tagged #ABPP

Great to hear the full story of this exciting project that is done in collaboration with, among others, @mads-chem.bsky.social of our @led3hub.bsky.social. (2/2)

#ChemBio #ChemSky #Synthesis #SAR #Tuberculosis #Virulence #ABPP #PAL

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#ABPP2027 will be happening in Leiden on June 2nd to 4th, 2027.

I am excited to be part of the organization together with an amazing team.

Sign up for our mailing list here: www.universiteitleiden.nl/en/science/l...

#ABPP #ChemoProteomics #ChemPro #ProteoProbes #ChemSky #ChemBio #DrugDiscovery

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#ABPP #ChemoProteomics #ChemPro #ProteoProbes #ChemSky #ChemBio #DrugDiscovery

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Designer Aromatic Cations for Photo-Induced Protein Ligation, Imaging, and Intracellular Labelling at Extended Wavelengths Photo-induced protein labelling strategies have become essential tools in chemical biology, but most strategies require high energy wavelengths of light as input to drive reactivity. Recently, we reported a biocompatible method for engaging photo-induced electron transfer to drive protein labelling using biaryl pyridinium salts and, here, we report the design of a series of aromatic cation salts that trigger this process using longer wavelengths of light while maintaining a sterically minimal profile. We achieved this through the systematic study of structure-reactivity relationships of various donor-acceptor pyridinium salts possessing extended conjugation, and these studies revealed the need of a constrained trans -stilbene relationship between the probe’s donor and acceptor substituents in order to achieve protein labelling. Probes with chromene-based donor groups in particular showed either robust protein labelling, significant fluorescence quantum yields, or state-dependent photophysical properties; in turn enabling the same probes to be used for both photo-induced protein labelling and wash-free live-cell imaging. We also demonstrate that these enhanced probes possess robust reactivity in complex biological environments through green light-triggered intracellular labelling in live HeLa cells, resulting in the identification of 659 enriched proteins. This series of experiments not only demonstrates the ability of this latest generation of probes to engage in photo-induced labelling using lower energy light in complex proteomes, but also reveals new capabilities for photophysical state-dependent reactivity and measurements. ![Figure][1]</img> ### Competing Interest Statement The authors have declared no competing interest. National Institute of General Medical Sciences, R35 GM143120 U.S. National Science Foundation, https://ror.org/021nxhr62, 1920234, 840336, 9214383, 9729350 [1]: pending:yes

Interesting @biorxivpreprint.bsky.social by the group of Michael Taylor. They designed new derivatives of N-substituted pyridinium salts for tryptophan labeling that allow labeling of the proteome with green light.

www.biorxiv.org/cont...
#ChemSky #ChemBio #ABPP #ChemPro #ProteoProbes

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Chemical proteomic profiling reveals prostaglandin termination enzyme PTGR2 as a key molecular target of natural coumarin fraxetin Natural coumarins represent a diverse group of secondary metabolites with a wide range of biological activities. However, their specific molecular targets have remained largely unexplored. Employing chemical proteomics, a comprehensive analysis of the protein targets of the natural coumarin fraxetin has been

Interesting talk by Weining Zhao at #ISCPDD. He talked about the use of #ChemicalProteomics to study the target proteins of Fraxetin. They identified PTGR2 as a relevant target in human cells.

pubs.rsc.org/en/cont...
#ABPP #AfBPP #ChemSky #ChemBio #ProteoProbes #ChemPro

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Tryptoline Stereoprobe Elaboration Identifies Inhibitors of the GRPEL1-HSPA9 Chaperone Complex Activity-based protein profiling has identified hundreds of proteins from diverse classes that react at specific cysteine residues with stereochemically defined electrophilic compounds (stereoprobes) ...

Interesting bioRxiv preprint by the group of Ben Cravatt and Bruno Melillo with first author Rachel Hayward. They profile tryptoline stereoprobes elaborated at remote positions with #ABPP and find striking influence of remote substituents on the target profile. (1/2)
doi.org/10.1101/2025...

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Probing the proteome - Nature Biotechnology Chemical proteomics has brought rigor to covalent drug discovery and drugs to the clinic. Can it deliver a new generation of drug targets?

I envy the glycoscience community for their #glycotime hashtag. A great way to make posts visible. Anyone in #ChemicalProteomics that has a good idea, which hashtag we might use to make all of our work more visible and findable?
#ChemSky #ChemBio #DrugDiscovery #ABPP
www.nature.com/articles/s41...

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Alabama Bureau of Pardons and Paroles officers officially recognized as law enforcement Gov. Kay ...

www.alreporter.com/2025/05/16/alabama-burea...

#Governor #Legislature #ABPP […]

[Original post on alreporter.com]

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Interesting paper by the groups of X. Lu, L. Zhou and Y. Sun in @angewandtechemie.bsky.social. #ABPP data guides warhead and target selection for lysine-directed DNA-encoded libraries with squaramides, salicylaldehydes and nitrobenzyl alcohols. (1/2) #ChemBio #Chemsky onlinelibrary.wiley....

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#FocusOnCovalentDrugs is off to a great start with an inspiring talk by Marcus Bantscheff. He talked about the various #chemoproteomics technologies that his group is applying to better understand the targets of small molecule drugs. Interesting insights into #ABPP and #TPP. (1/2)
#chemsky #ChemBio

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I would never vote for a politician who wears pancake makeup and a smirk. And the fact that he’s now using women escaping abusive relationship as props is disgusting. #abpp

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I would never trust a politician who wears pancake makeup. And the fact that he’s using women escaping abusive relationships as props is disgusting. #abpp

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Like how you captured his pancake make up. What repulses me about him is now he’s pretending to care about women who have been in abusive relationships and he’s using them as props. #abpp

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Had an amazing time at #abpp2025 over the last couple of days. Incredible lineup of speakers showcasing why #ABPP and #proteomics have transformational for #drugdiscovery and #chembiol
Already looking forward for #abpp2027 in @LeidenScience

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The flash talk session and the posters were a highlight of #ABPP2025. We heard a lot of exciting research into #covalent #fragment screening, #antibiotic development, #microbiome activities, posttranslational modifications #PTMs and lysine-directed #kinase inhibitors.
#ABPP #ChemSky #ChemBio

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ABPP2025: The 14th International Activity Based Protein Profiling Meeting | March 30, 2025 - April 02, 2025 Join us on March 30

Looking forward to the #ABPP2025 meeting in London starting this weekend. An amazing lineup of world-leading speakers in the field from academia and industry!

If you are there on Saturday or Sunday morning and want to catch up, send me a message!

#ABPP #ChemBio

www.eventcreate.com/e/abpp2025/

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S-Palmitoylation during Retinoic Acid-Induced Neuronal Differentiation of SH-SY5Y Neuroblastoma Cells S-Palmitoylation is the covalent attachment of C14:0–C22:0 fatty acids (mainly C16:0 palmitate) to cysteines via thioester bonds. This lipid modification is highly abundant in neurons, where it plays ...

He then zoomed in on protein S-palmitoylation as the main modification that his group is interested in. In this context, he introduced the power of #ABPP to study this modification. (3/5) pubs.acs.org/doi/full/10....

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Inspiring keynote lecture by Uwe Grether of Roche at the #Lunteren meeting of the #SOC and #MCCB divisions of KNCV. He talked about the impressive story of developing MAGL inhibitors into the clinics through a huge diversity of technologies including #ABPP, #AI, #LSF and #HTE.

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If you are interested in Activity-Based Protein Profiling, check out my starter pack on Past and present members of the Ben Cravatt lab! Recent additions include:
@alansaghatelian.bsky.social
@hsinyulee.bsky.social
@mads-chem.bsky.social
#ABPP #ChemBio #chemsky
go.bsky.app/LZR93i3

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If you are looking for exciting scientific content (with a focus on #ChemBio, #ChemSky, #ABPP, #ChemicalProteomics), check out these starter packs:
short list: go.bsky.app/C4URhFa
pack 1: go.bsky.app/3SyoVNw
pack 2: go.bsky.app/9keb2TP

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#chemsky #ChemBio #ABPP

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#chemsky #ChemBio #ABPP

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Our Typhoon arrived! 🤩 #happy #ABPP #CellDeath

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Verhelst Lab – Laboratory of Chemical Biology

Hello #chemicalbiology community on bluesky! Some of you may know my lab. We work on covalent chemical probes with a main focus on proteases. #abpp #chemicalproteomics You can visit www.verhelstlab.net or check our papers on pubmed.

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Very excited to see the scientific community forming over here and to have reached 500 followers. I will try to ramp up my activities again posting on literature on #Science, #Chemistry, #Chemsky, #ChemicalBiology, #Antibiotics, #CovalentInhibitors, #ChemicalProteomics and #ABPP.

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Great to see so many new people from the scientific community joining here. Welcome! I would be very happy to connect with everyone on topics such as #Science, #Chemistry, #Chemsky, #ChemicalBiology, #Antibiotics, #CovalentInhibitors, #ChemicalProteomics, #ABPP and general topics of #academia.

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