Visual Abstract for ASCO-SNO Guideline
Therapy for Diffuse Astrocytic and Oligodendroglial Tumors in Adults
Rapid Guideline Update
Oligodendroglioma, IDH-mutant, 1p19q co-deleted, CNS WHO grade 2
Options Include:
- RT + PCV
- When toxicity is a concern, RT + temozolimide
- For some people with favorable prognostic factors or concerns about toxicity, deferred RT + chemotherapy until radiographic or symptomatic progression
- After 1+ surgeries, when RT + chemotherapy has been or can be deferred, vorasidenib may be offered
Astrocytoma, IDH-mutant, 1p19q non-codeleted, CNS WHO grade 2
Options include:
- RT + adjuvant chemotherapy (temozolimide or PCV)
- For some people with favorable prognostic factors or concerns about short- and long-term toxicity, deferred RT + chemotherapy until radiographic or symptomatic progression
- After 1+ surgeries, when RT + chemotherapy has been or can be deferred, vorasidenib may be offered
Mohile et al J Clin Oncol 2025
asco.org/neurooncology-guidelines
Rapid recommendation update from @ascocancer.bsky.social & @neuroonc.bsky.social on therapy for diffuse astrocytic & oligodendroglial tumors in adults #ASCOguidelines #oncsky #medsky
ascopubs.org/doi/full/10....