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Judge decides DOGE bros don't have to face the consequences of their actions
Judge decides DOGE bros don't have to face the consequences of their actions YouTube video by Dr. Arghavan Salles, MD, PhD

White Male Privilege 101: Judge orders that DOGE incels disposition videos of terminated grants be removed because of "harassment".
#AcademicSky #MedSky #EduSky

www.youtube.com/shorts/OPgGs...

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https://doi.org/10.1001/jamapsychiatry.2026.0086 No description available

New JAMA Psychiatry paper: Clozapine is tested after 1 antipsychotic failure in FEP. Study spans 7 sites in China, 2 randomizations! PMID:41811299, JAMA Psychiatry 2026, @JAMAPsych https://doi.org/10.1001/jamapsychiatry.2026.0086 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

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Cancer cachexia in STK11/LKB1-mutated non-small cell lung cancer is dependent on tumor-secreted GDF15 | Nature Communications Cachexia is a wasting syndrome involving adipose, muscle, and body weight loss in cancer patients. Tumor loss-of-function mutations in STK11/LKB1, a regulator of AMP-activated protein kinase, induce cancer cachexia (CC) in preclinical models and are linked to weight loss in non-small cell lung cancer (NSCLC) patients. This study examines the role of the integrated stress response (ISR) cytokine growth differentiation factor 15 (GDF15) in regulating cachexia using patient-derived and engineered STK11/LKB1-mutant NSCLC lines. Tumor cell-derived serum GDF15 levels are elevated in mice bearing these tumors. Treatment with a GDF15-neutralizing antibody or silencing GDF15 from tumor cells prevents adipose/muscle loss, strength decline, and weight reduction, identifying tumors cells as the GDF15 source. Restoring wild-type STK11/LKB1 in NSCLC lines with endogenous STK11/LKB1 loss reverses the ISR and reduces GDF15 expression rescuing the cachexia phenotype. Collectively, these findings implic

GDF15 is key to cachexia in STK11/LKB1-mutant lung cancer. Blocking it could halt muscle, fat, and weight loss. Insights from patient-derived models. PMID:41617691, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-68702-y #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

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#MedSky #PatientExperience #PublicHealth

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been killed so far in Operation Epic Fury. 🙏 #BlueSky #MedSky #iran #war #LawSky #PoliSky

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Advanced Practice Physiotherapist scope of practice

doi.org/10.1111/1742...

#OpenAccess

@wileyhealth.bsky.social
#MedSky #EMSky #EMedSky #emimcc #ACEM

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Just spit ballin' here - but how about we make taxes fully transparent?

You know - like the GINORMOUS tax on wages for healthcare benefits through an employer (~165M Americans).

FWIW - the tax exclusion is the Gov's largest tax expenditure.

#Medsky

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Suck It Up, Buttercup - Irreverent Health Suck It Up, Buttercup Trust & Betrayal Healthcare in America Exclusive ScreeningMarch 19 • 7:00 PMThe Senator Theatre • Baltimore, MDExclusive Screening Proudly Hosted by Irreverent Health Buy Tickets...

Our exclusive screening is hosted by Irreverent Health on March 19th.

🎟 Tickets are still available!

irreverenthealth.com/suck-it-up-b...

A special thank you to our hosts from the Irreverent Health Podcast, Matt Hampton & Dr. Tom Ingegno, for supporting this documentary. #fpsky #emsky #medsky

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Bar graph of addition/loss of social workers, psychologists & psychiatrists. The losses under the new administration amount to 4% of the agency’s psychologists, 6% of psychiatrists and 3% of social workers.

Bar graph of addition/loss of social workers, psychologists & psychiatrists. The losses under the new administration amount to 4% of the agency’s psychologists, 6% of psychiatrists and 3% of social workers.

The Trump administration is worsening mental health care for American veterans.

Fewer psychiatrists, psychologists & social workers --> less access & longer wait times for veterans with mental illness.

www.propublica.org/article/vete... #medsky

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Report details Eagle County avalanche that killed a solo skier, marking the first fatality of the 2025-26 season A companion “could have produced a different outcome,” for solo skier David Pickett-Heaps, CAIC avalanche investigators said

Backcountry rule: Don’t go alone.
coloradosun.com/2026/03/13/f... #BlueSky #MedSky #SkiSky #SportsSky

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De novo design of GPCR exoframe modulators | Nature G-protein-coupled receptors (GPCRs) are important therapeutic targets and have been targeted mainly through their orthosteric site, where the endogenous agonist binds1. However, allosteric modulation has emerged as a promising and innovative strategy in the realm of GPCR drug discovery1. Here, drawing inspiration from the natural regulation of GPCRs by transmembrane proteins, we have developed GPCR exoframe modulators (GEMs), de novo designed proteins that specifically target the transmembrane domain of GPCRs. Utilizing a hallucination-like design approach, we crafted GEMs with three strategic structural prompts to achieve the desired binding modes. We selected the dopamine D1 receptor as a prototypical model and systematically investigated four GEMs. Structural studies and functional assays revealed that these GEMs bind to the transmembrane domains and function as diverse allosteric modulators, including agonist-positive allosteric modulator, negative allosteric modulator and biased a

Innovative GPCR exoframe modulators tune allosteric sites for precise targeting. De novo proteins open pathways for future solutions in drug discovery. PMID:41699180, Nature 2026, @Nature https://doi.org/10.1038/s41586-025-09957-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

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Prediction of Inpatient Admission From ED Using Ensemble Machine Learning

doi.org/10.1111/1742...

@wileyhealth.bsky.social
#MedSky #EMSky #EMedSky #emimcc #ACEM

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Last Thursday's wonderful Morning Report session on ARDS by PGY-2 Juan Urraca took our breath away 😮‍💨 #MedEd #elmhurstmedicine #MedSky

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law, no president can pardon you. 💥

www.instagram.com/reel/DVyw2QC... #BlueSky #MedSky #LawSky #epstein #PoliSky

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#medsky

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A malignant narcissist "He's both evil and demented". "potentially fatal to our country""sadism..gleefully destructive and harmful, it gives him enormous pleasure to hurt people and destroy things"

#discover #Epstein #MentalHealthMatters #Medsky

bsky.app/profile/spoc...

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Livestream communities for AI-generated video content: Viewers’ motivations and perceptions of toxicity and moderation AI is transforming live streaming with new communities forming around channels featuring automated or prompt-based AI-generated videos. By introducing…

"...viewers were more engaged by #AI interactions & user-generated prompts than by other viewers, & toxicity arose from various sources & negatively related to the sense of community, w/most viewers favouring in-community moderation." www.sciencedirect.com/science/arti...

#MedSky #PatientExperience

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They Didn’t Want to Have C-Sections. A Judge Would Decide How They Gave Birth. Two Florida women had to attend virtual court hearings while in labor to argue for their right to choose their own medical care. As their state pushes to expand some types of medical freedom, it has a...

Obstetricians and other healthcare workers:

This should never happen.

It should never happen again at this hospital, it should never happen at any hospital

Full stop

#Medsky #Reprosky

www.propublica.org/article/flor...

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In Huntington Disease, 2 Biomarkers Track Striatal Atrophy in Opposite Directions Two biomarkers, NfL and TNFRSF8, show opposite associations with putamen volume in HD, suggesting a dual-pathology model of striatal atrophy.

An ultrasensitive cerebrospinal fluid (#CSF) proteomic analysis using the Next-Gen Ultra-Sensitive Immunoassay (#NULISA™) platform identified a dual-pathology model underlying striatal degeneration in #HuntingtonDisease.

Learn more: https://bit.ly/4ulLwgg

#RareDisease #MedSky

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📢 3 days left!🎨 Do not forget our call for #CoverArt is only open until *Monday, March 16*! Whether you’re a #physician, #resident, #medstudent, #premed, or #patient, your art could be featured on our cover. Learn more & submit: https://bit.ly/4qFJuVB #MedSky

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Machine Learning Operations Engineer in Irvine, California | University of California, Irvine Careers Home is hiring a Machine Learning Operations Engineer in Irvine, California. Review all of the job details and apply today!

If you are experienced in managing Python, R, and/or SQL software projects; use data science and ML best practices; love research on infectious diseases; and want to join a growing computational lab based in SoCal...

➡️ Apply today! jobs.uci.edu/careers-home...

#EpiSky #SciSky #MedSky #IDSky 🧪 2/x

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Theodore Pak's Lab Using A.I. to accelerate research on infectious diseases. We work at the intersection of epidemiology, clinical informatics, microbial genomics, and computer science. Our lab is based in the Division ...

🚨 My lab is hiring! @ucirvine.bsky.social Seeking full-time data scientists & machine learning engineers.

We apply LLMs and AI tools to clinical data, rapidly scaling up epidemiological analyses and models of sepsis, hospital-acquired infections, and more. tpaklab.org #MedSky #IDsky 🧪 1/x

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Immediate iFR-guided PCI does not outperform deferred MRI-guided PCI for nonculprit lesions in STEMI patients after three years.

by Nijveldt R, Maeng M (...) van Royen N et 44 al. in N Engl J Med #MedSky

👉 get more here

📖 read the article: https://www.nejm.org/doi/10.1056/NEJMoa2512918

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Discover Journal Series

Discover Journal Series

Discover Journal Series

Discover Journal Series

Discover Journal Series

Discover Journal Series

Discover Journal Series

Discover Journal Series

Where did your #research direction begin?
Dr. Dauda Garba shares how a molecular docking workshop evolved into a peer-reviewed study on drug-resistant malaria, a strong example for early-career researchers building their path.
Read more here: bit.ly/4cQdnz3

#MedSky

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Loss of Methylthioadenosine Phosphorylase (MTAP) Expression: A Potentially Useful Tool for Distinguishing Sarcomatoid Urothelial Carcinoma from Inflammatory Myofibroblastic Tumor Inflammatory myofibroblastic tumor (IMT) and sarcomatoid urothelial carcinoma (SarUC) can have striking histologic overlap but have significantly different prognoses and clinical management…

Loss of Methylthioadenosine Phosphorylase (MTAP) Expression: A Potentially Useful Tool for Distinguishing Sarcomatoid Urothelial Carcinoma from Inflammatory Myofibroblastic Tumor

✅ Just Accepted
📗 @modernpathology.bsky.social

#pathology #PathSky #MedSky

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The Skeptics Guide to Emergency Medicine Education Podcast · Updated Biweekly · Meet 'em, greet 'em, treat 'em and street 'em

Link to the SGEM podcast reviewing the RENOVATE Trial with guest skeptic Dr. Rory Spiegel #MedSky

podcasts.apple.com/ca/podcast/t...

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Great idea. He could call it "Operation ICE Iran."
Betting some ICE might melt pretty quickly...
#BlueSky #MedSky #LawSky #PoliSky

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Who is fighting for pediatricians if we are too busy fighting for the kids?

Who is fighting for pediatricians if we are too busy fighting for the kids?

In 2025, 30% of some pediatric subspecialty fellowship programs went unfilled.

Not because trainees stopped caring about children.

Because more of them are asking a different question:

Can you build a sustainable life in pediatrics?

#medsky #pedsky #academicsky

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Exploring Alice in Wonderland syndrome in adults with persistent headache after COVID-19: a cross-sectional study in Latin America - BMC Neurology Background Alice in Wonderland syndrome (AIWS) is a neuropsychiatric disorder characterized by sensory perception distortions, including altered body image perception and distortions of shape, size, motion, color, and speed. Migraine and infectious diseases are among the most common etiologies of AIWS. However, it has not been studied in individuals with persistent headache after COVID-19. Methods This cross-sectional study included a subset of individuals with AIWS symptoms derived from a survey conducted in Latin America to identify adults with persistent headache after COVID-19. For data analysis, AIWS individuals were characterized by sex and analyzed using univariable tests. Subsequently, the entire study cohort was stratified into two groups: the AIWS group and the non-AIWS group. Binomial logistic regression using the backward stepwise selection method was performed to identify the factors associated with AIWS after COVID-19. Results Out of 421 participants with persistent headache after COVID-19, 106 (25.2%) reported at least one AIWS symptom. The AIWS group was significantly younger (median age 36 vs. 39 years, p = 0.011) and had a higher proportion of pre-existing migraine (40.6% vs. 29.5%, p = 0.035) compared to the non-AIWS group. The most common post-COVID-19 AIWS symptoms were time distortion (32.1%), derealization/depersonalization (24.5%), and hyperchromatopsia (20.8%). Logistic regression analysis revealed that experiencing any AIWS symptom during acute COVID-19 was the strongest predictor for post-acute AIWS (OR = 9.937, 95% CI = 5.603–17.62, p <0.001). Other significant predictors included phonophobia (OR = 2.322, 95% CI = 1.288–4.185, p = 0.005) and depressive symptoms (OR = 1.937, 95% CI = 1.099–3.413, p = 0.022) during acute COVID-19. Conclusion In this cohort, AIWS was a notable feature in adults with persistent headache after COVID-19, particularly in younger individuals with a history of migraine. Experiencing AIWS symptoms during acute infection increased the odds of post-acute AIWS symptoms nearly tenfold, suggesting SARS-CoV-2 may be a potent trigger. Clinicians should be aware of this association and screen for perceptual disturbances in patients with post-COVID-19 neurological sequelae.

A study in BMC Neurology reveals that Alice in Wonderland syndrome, a neuropsychiatric disorder marked by sensory perception distortions and altered body image, is prevalent in younger adults with persistent headaches post-COVID-19, particularly those with a migraine history.
#MedSky

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Zorevunersen cuts convulsive seizures by up to 90% in children with Dravet syndrome, showing promise for long-term treatment.

by Laux L, Sullivan J (...) Cross JH et 14 al. in N Engl J Med #MedSky

👉 get more here

📖 read the article: https://www.nejm.org/doi/10.1056/NEJMoa2506295

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