Examples of high and low WMH load. FLAIR scans for 2 ABC participants in their 70s with white matter hyperintensities highlighted in red in the left scan in each pair. The images on the left side of the panel show coronal (A) and axial (B) views of a brain with a low WMH load while the scans on the right (C and D) show the same views of a participant with a high WMH load.
Pulse pressure, not MAP, mediates age-related WMH burden, linking vascular stiffness to cognitive decline. WMH load also mediates the age-MoCA relationship. Arterial health isn't just cardiac-it's cognitive.
Full text: doi.org/10.1002/acn3...
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