Latest posts tagged with #Allosteric on Bluesky
Speaking of #allostery: What happens when you mutate the #CannabinoidReceptor (CB1) in silico with a single-point mutation?
Find out👉: doi.org/10.1021/acso...
Spoiler😉: The F237L mutation mimics #allosteric #ligand effects, globally altering #receptor conformations and hindering activation
#GPCR
🎯Feature Alert 🚨
This paper delves into how #BindingKinetics reshape our understanding of #allosteric modulation. When it comes to cooperativity effects, it's all about
👉 WHERE molecules bind
👉 HOW FAST
👉 and in WHICH SEQUENCE
🔗 doi.org/10.1016/j.dr...
#allostery #pharmacology #DrugDesign #GPCRs
Came across this #kinase work, very cool for where in trials the compound is. Interesting commentary noting AI focus on #allosteric sites (notoriously hard to model de novo) although truthfully traditional type I cmpds were extended into a back pocket, so not type III #medchem
rdcu.be/ev0b6
The NUDT5-PPAT interaction appears to be disrupted by PRPP in a #physiological feedback loop! Indeed PRPP serves not only as the PPAT substrate but also as its main #allosteric activator!
⚙️ High PRPP → dissociation of NUDT5 from PPAT → increased purine synthesis
7/9
#Bacterial species study challenges assumption that #structural similarity predicts #protein behavior
#Escherichia #Mycobacterium #cAMP #CRP #Allosteric #homology
phys.org/news/2025-02...
Chiral Pt(II)–V(V) Bimetallic Cages and Guest-Induced Allosteric Regulation of Catalytic Asymmetric Sulfoxidation pubs.acs.org/doi/10.1021/... Zhang, Zhang, Gao, & co-workers @InorgChem #platinum #vanadium #cages #guest_induced #allosteric #catalysis #asymmetric #sulfoxidation
We talk about the promises of precision #medicine and the unexplored world of targeting #allosteric sites, the new utilities in the toolbox of a computational #chemist, and what a journal editor and an entrepreneur can contribute to their communities. Spoiler: there's plenty of work ahead 🧑🔧
Application of cryo-EM to solve the inactive strutture of #CCR6 bound to small-molecule #allosteric #inhibitors 🧪💊
www.nature.com/articles/s41...
We use our method on SARS-CoV-2 main protease #MPro and both #active site and potential #allosteric #sites are classified as #Cluster1 sites, demonstrating that these RSA-based Cluster labels can #recapitulate known #functional protein regions such as active or allosteric sites
