Targeting #amyloid-β pathology by chimeric antigen receptor #astrocyte (CAR-A) therapy | Science www.science.org/doi/10.1126/...
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#Astrocyte
Latest posts tagged with #Astrocyte on Bluesky
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Posts tagged #Astrocyte
Helping Spinal Cords Heal. The neural support cell, the astrocyte, plays a crucial role in spinal cord healing following injury. #spinalcord #injury #astrocyte #ccn1
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✨ Astrocyte Crosstalk: Simultaneous #norepinephrine & #astrocyte calcium imaging in the hippocampus.
👁️ Precision: Mapping discrete NE release in the visual cortex.
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#Research by Zhou Wu, Lukas Henning, Christian Steinhäuser and Peter Bedner from @unibonn.bsky.social finds that targeting #necroptosis protects against #astrocyte death and hippocampal sclerosis in experimental temporal lobe #epilepsy 🧠 🔬
📜 physoc.onlinelibrary.wiley.com/doi/10.1113/...
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Thru an unbiased, forward genetic screen in Drosophila,
@volluminstitute.bsky.social's Dongeun Heo found unexpected, non-neuronal role for dSarm/SARM1 pathway in #Astrocyte morphogenesis. INTERESTED? JOIN Swagata Dey, Batuhan Ayci & @chloelopezlee.bsky.social when they host Dr Heo at #MSNseminars
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🧠 A new study led by our PI Marta Llinás published in Nature Communications shows that a specific #astrocyte ensemble drives memory deficits caused by adolescent #cannabis use in mice.
🔬 Reducing their overactivation prevents cognitive impairments.
More info🔗https://shorturl.at/Mxih0
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Thru an unbiased, forward genetic screen in Drosophila, @volluminstitute.bsky.social's Dongeun Heo found an unexpected, non-neuronal role for dSarm/SARM1 pathway in #Astrocyte morphogenesis. INTERESTED? JOIN Swagata Dey, Batuhan Ayci & @chloelopezlee.bsky.social when they host Dr Heo at #MSNseminars
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Research Spotlight 💡
New study shows #astrocyte reactivity in #Alzheimers depends on activated #microglia. PET imaging & biomarkers reveal microglia drive Aβ-linked astrocyte reactivity, tau pathology, and cognitive decline.
🔗 https://www.nature.com/articles/s41593-025-02103-0
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@drnicolecampbell.bsky.social once again wowing us with a showstopper at the @ciiid-hudson.bsky.social Xmas party. Individual macarons shaped like different the cells we work on, including #macrophage #neuron #NKcell #astrocyte #bacteria #virus
Amazing! 🧪👩🍳
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NEP1-40 Regulates the Development of Hippocampal Neural Stem Cells in Schizophrenic Mice
Researchers demonstrate that NEP1-40 promotes hippocampal #NeuralStemCell differentiation into #neurons and reduces #astrocyte proliferation and #neuronalapoptosis, leading to improved #cognitive and behavioral symptoms in #schizophrenia mouse models.
Read: doi.org/10.1007/s115...
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In the image is an #ImmunoFluorescence staining of #GFAP (Glial Fibrillary Acidic Protein), an #astrocyte #protein used as a #biomarker for several #NeurologicalConditions. Specific biomarkers are important for accurate #diagnosis and compatible treatment, the essential parts of good #healthcare.
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Rodriguez Salazar, @caglaeroglu.bsky.social et al. show that Drp1-mediated mitochondrial fission is necessary for peripheral #astrocyte process formation. rupress.org/jcb/article/...
📕 Part of The Year In Cell Biology: rupress.org/jcb/collecti...
#CellBio2025 #Mitochondria
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🧠 Astrocytes protect the brain during viral infection! Lindman et al. (2025) show #astrocyte RIPK3 triggers serpins that preserve the blood-brain barrier & limit immune cell influx. RIPK3 deletion → lower survival, same viral load. 📖 https://www.science.org/doi/10.1126/scisignal.adq6422
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Read the original study*, published in @nature.com #Neuro: tinyurl.com/22hunpuz
#BrainStars #Astrocyte #Alzheimers
*Subscription required for access
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Excited to share that our study has been accepted in Progress in Neurobiology!🎉
We show that cocaine activates the JAK-STAT3 pathway in astrocytes, and that reducing this reactivity mitigates cocaine-induced hyperlocomotion.
www.sciencedirect.com/science/arti...
#astrocyte #cocaine #glia #brain
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Rodriguez Salazar, @caglaeroglu.bsky.social et al. show that Drp1-mediated mitochondrial fission is necessary for peripheral #astrocyte process formation. rupress.org/jcb/article/...
📕 In Cellular Neurobiology collection: rupress.org/jcb/collecti...
#SfN25
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Pour comprendre les travaux de recherche sur les #mécanismes de régulation du sommeil !
m.youtube.com/watch?v=nHTb...
@pslqlife.bsky.social @inserm.fr #Cirb
#astrocyte
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'Interplay between #astrocyte reactivity and #APOE ε4 status is associated with accelerated #pTau-related tau pathology in #AlzheimersDisease'
Xiaoxie Mao, Yan Wang, Ying Luan, Ying Wang...Binyin Li, Zijing Li, Qihao Guo, Fang Xie
molecularneurodegeneration.biomedcentral.com/articles/10....
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Serum proteomics in people with pre-symptomatic #MultipleSclerosis reveals #myelin damage up to 7 years before symptoms—preceding axonal injury by ~1yr. #Astrocyte involvement emerges only at clinical onset. #MS
www.nature.com/articles/s41...
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#microscopymonday video on a multitalented housekeeper in the #brain: Watch amidst #neurons an #astrocyte. The astrocyte phagocytoses debris but is rather stationary compared to the bypassing #microglia cell. #Neurons thrive around the astrocyte and outgrow neurites.
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Astrocytes, Not Neurons, Hold the Key to Emotional Memory
#neuro #astrocyte #memory #learning #emotion #psychiatry 🧪
neurosciencenews.com/astrocytes-e...
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Neuroscientists pinpoint #astrocyte #brain cell as key to converting emotional experiences into long-term #memories; finding could inform future treatments for memory-related conditions such as #PTSD and #Alzheimer's.
www.genengnews.com/topics/trans...
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Top: Example confocal micrograph showing astrocyte expression of S100β (green), Cre-RFP (magenta), and H1R mRNA (cyan). Left: summed z-projection of all three confocal channels. Middle: RNAscope detected H1R mRNA with white and yellow arrows indicating example WT (S100β+/RFP−/H1R+) and cKO (RFP+/H1R−) soma regions of interest (ROIs), respectively. Right: Cre-RFP expression (top, magenta) and S100β expression (bottom, green). Scale bars = 10 μm. Bottom: Example confocal micrograph showing astrocytic Cre-RFP (magenta), neuronal NeuN (green), and nuclear marker DAPI (blue). Left: summed z-projection of all three confocal channels. Middle: astrocytic Cre-RFP signal with astrocyte soma ROIs overlaid. Right: NeuN signal with astrocyte soma ROIs overlaid. Scale bars = 50 μm.
What's the function of #histamine -1-receptors (H1Rs) on cortical astrocytes? @kiraposkanzer.bsky.social & co show that astrocytic H1R signaling modulates Ca2+ activity, extracellular adenosine & REM #sleep, revealing a key #astrocyte role in sleep-wake regulation @plosbiology.org 🧪 plos.io/4gRj9Ap
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Top: Example confocal micrograph showing astrocyte expression of S100β (green), Cre-RFP (magenta), and H1R mRNA (cyan). Left: summed z-projection of all three confocal channels. Middle: RNAscope detected H1R mRNA with white and yellow arrows indicating example WT (S100β+/RFP−/H1R+) and cKO (RFP+/H1R−) soma regions of interest (ROIs), respectively. Right: Cre-RFP expression (top, magenta) and S100β expression (bottom, green). Scale bars = 10 μm. Bottom: Example confocal micrograph showing astrocytic Cre-RFP (magenta), neuronal NeuN (green), and nuclear marker DAPI (blue). Left: summed z-projection of all three confocal channels. Middle: astrocytic Cre-RFP signal with astrocyte soma ROIs overlaid. Right: NeuN signal with astrocyte soma ROIs overlaid. Scale bars = 50 μm.
What's the function of #histamine -1-receptors (H1Rs) on cortical astrocytes? @kiraposkanzer.bsky.social & co show that astrocytic H1R signaling modulates Ca2+ activity, extracellular adenosine & REM #sleep, revealing a key #astrocyte role in sleep-wake regulation @plosbiology.org 🧪 plos.io/4gRj9Ap
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Top: Example confocal micrograph showing astrocyte expression of S100β (green), Cre-RFP (magenta), and H1R mRNA (cyan). Left: summed z-projection of all three confocal channels. Middle: RNAscope detected H1R mRNA with white and yellow arrows indicating example WT (S100β+/RFP−/H1R+) and cKO (RFP+/H1R−) soma regions of interest (ROIs), respectively. Right: Cre-RFP expression (top, magenta) and S100β expression (bottom, green). Scale bars = 10 μm. Bottom: Example confocal micrograph showing astrocytic Cre-RFP (magenta), neuronal NeuN (green), and nuclear marker DAPI (blue). Left: summed z-projection of all three confocal channels. Middle: astrocytic Cre-RFP signal with astrocyte soma ROIs overlaid. Right: NeuN signal with astrocyte soma ROIs overlaid. Scale bars = 50 μm.
What's the function of #histamine -1-receptors (H1Rs) on cortical astrocytes? @kiraposkanzer.bsky.social & co show that astrocytic H1R signaling modulates Ca2+ activity, extracellular adenosine & REM #sleep, revealing a key #astrocyte role in sleep-wake regulation @plosbiology.org 🧪 plos.io/4gRj9Ap
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A 3D fibrin hydrogel supportive neurovascular cell niche
17 kPa ECM stiffness
👤🧠 #EndothelialCell #Pericyte #Astrocyte
⏫Quiescence, invasiveness, temozolomide resistance of patient-derived #Glioblastoma stem cell lines or tumorsphere
#AdvSci 2025
advanced.onlinelibrary.wiley.com/doi/10.1002/...
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An #astrocyte carved out of a piece of walnut wood and mounted on a big chunk of red oak. This piece is available for purchase!
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Karmen Mah, Adam Roszczyk, and Ashley E Frakes carefully characterized the #astrocyte driver hGFAP-CreERT2 recombination with LSL-TdTomato, showing Cre is the paternally inherited and is suppressed when maternally inherited. (1/2)
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A Cell Reports article from the Saunders Lab (Vollum Institute/OHSU) describes the unique role of #astrocyte innate immune signaling in combating viral #infection.
Read the article in Cell Reports: bit.ly/4gf707M
cc: @your-arpy.bsky.social , @cp-cellreports.bsky.social
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