#NKcell

1 month ago

Scientists highlight how #lncRNAs regulate #NKcell development, activation, #cytotoxicity, and #TumorInfiltration via transcriptional control, #miRNA sponging, metabolism, ubiquitination, and epigenetics, highlighting their therapeutic potential.

#OpenAccess: doi.org/10.1016/j.ge...

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1 month ago

A phase 1b/2 trial shows that #allogeneic #NKcell therapy plus #chemotherapy is safe in #AdvancedPancreaticCancer, with 31.6% response; #MultiomicProfiling reveals NK/T‑cell subsets linked to outcomes, offering novel immune insights.

#OpenAccess in STTT: doi.org/10.1038/s413...

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MedComm

@medcomm.bsky.social

1 month ago

#Article in #MedComm
Low Dose of #IL_2 Application for Graft-Versus-Host Disease (#GVHD) Prophylaxis Following Haploidentical Stem Cell Transplantation doi.org/10.1002/mco2...

#Tregs #interleukin_2 #NKcell

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Overexpressing natural killer group 2 member A drives natural killer cell exhaustion in relapsed acute myeloid leukemia - Signal Transduction and Targeted Therapy Signal Transduction and Targeted Therapy - Overexpressing natural killer group 2 member A drives natural killer cell exhaustion in relapsed acute myeloid leukemia

2 months ago

Relapsed #AML drives #NKCell exhaustion via the NKG2A/HLA‑E axis and PI3K‑AKT suppression; blocking NKG2A or restoring #AktPhosphorylation enhances #cytotoxicity, highlighting a strategy to optimize NK cell‑based #immunotherapies. @pku1898.bsky.social

#STTT: doi.org/10.1038/s413...

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Journal of Experimental Medicine

@jem.org

2 months ago

Cayatte, Picant, Vétizou, & Vivier @ciml.bsky.social review current insights into human #NKcell heterogeneity and function, their roles in viral #infection, #autoimmunity, #neurodegeneration, and #transplantation, and the emerging therapeutic opportunities they offer. rupress.org/jem/article/...

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@drnatsampaio.bsky.social

2 months ago

#ACAT1 acquires a nuclear role in #ColorectalCancer, where S60 phosphorylation enables p50 acetylation, relieves #NFκB repression, enhances #NKcell recruitment, while nutrient stress blocks this axis and drives #ImmuneEvasion and poor prognosis.

#STTT: doi.org/10.1038/s413...

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Natalia Sampaio

3 months ago

@drnicolecampbell.bsky.social once again wowing us with a showstopper at the @ciiid-hudson.bsky.social Xmas party. Individual macarons shaped like different the cells we work on, including #macrophage #neuron #NKcell #astrocyte #bacteria #virus
Amazing! 🧪👩‍🍳

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EMBO Molecular Medicine

@embomolmed.org

3 months ago

Loss of #EHMT2 enhances #NKcell -driven #AntiTumorImmunity through #TGFβ1 suppression

by S. Chava, R. Gupta, N. Wajapeyee & colleagues
@uofalabama.bsky.social

doi.org/10.1038/s443...

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Arindam Ray

@raydfci.bsky.social

3 months ago

Feeling great to have presented my work at #ASH25. What an amazing conference this has been! Thank you for the wonderful opportunity! Looking forward to the ASH meeting next year and hope to showcase again our work from @danafarber.bsky.social
#Hematology #leusm #lymsm #ashawards #NKCell

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Arindam Ray

@raydfci.bsky.social

3 months ago

Excited to give an Oral Presentation of my work at the @ash.hematology.org Annual Meeting in Orlando, Florida on Dec 6th. Happy to have received the #AbstractAchievementAward
Looking forward to a great meeting and scientific discussions!
#ASH25 #ASHAwards #NKCell #Lymsm #Leusm #ImmunOnc #Hematology

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STAT3 regulates NK and NKT cell differentiation through C-X3-C motif chemokine receptor 1 (CX3CR1) in hyper-IgE syndrome - Molecular Biomedicine Mutations in the signal transducer and activator of transcription 3 (STAT3) gene are strongly associated with Hyper-IgE Syndrome (HIES), a rare immunodeficiency disorder characterized by elevated leve...

4 months ago

TSC22D3 deficiency enhances #NKcell function, shifting immune responses to CD8+ T cells via cytokine- and contact-dependent pathways, highlighting TSC22D3-regulated NK cells as key regulators of SCARs #Pathogenesis.

#STTT #OpenAccess: doi.org/10.1038/s413...

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Molecular Biomedicine

@mol-biomed.bsky.social

4 months ago

#Research
STAT3 regulates NK and NKT cell differentiation through C-X3-C motif chemokine receptor 1 (CX3CR1) in hyper-IgE syndrome doi.org/10.1186/s435...

#STAT3 #mutation #Hyper_IgE #syndrome #NKcell #CX3CR1

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5 months ago

This review shows that #lncRNAs govern #NKcell biology in #Pathological conditions, and highlights that their regulatory role in the #TumorMicroenvironment positions them as novel #therapeutic targets in NK cell #Dysfunction. #medsky
#OpenAccess:
www.sciencedirect.com/science/arti...

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5 months ago

This review shows that #lncRNAs govern #NKcell biology in #Pathological conditions, and highlights that their regulatory role in the #TumorMicroenvironment positions them as novel #therapeutic targets in NK cell #Dysfunction. #medsky
#OpenAccess:
www.sciencedirect.com/science/arti...

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5 months ago

Relapsed #AML drives #NKCell exhaustion via NKG2A/HLA-E–mediated suppression of the PI3K-AKT pathway, while NKG2A blockade restores AKT signaling & #cytotoxicity, offering a strategy to boost NK cell–based #immunotherapy. @pku1898.bsky.social

#OpenAccess: doi.org/10.1038/s413...

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