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Identification of a potent V3 glycan site broadly neutralizing antibody targeting an N332gp120 glycan-independent epitope - Nature Immunology An anti-HIV-1 antibody that targets an N332gp120 glycan-independent V3 epitope, a site of Env vulnerability, can decline viremia in HIV-1-infected humanized mice while overcoming classical V3 escape m...

bNAb #007.

#HIV #antibody #V3 #avidity #cryo-EM

www.nature.com/articles/s41...

Cryo-EM revealed trimers with 0, 1, 2, or 3 Fabs bound -leading to some surprising insights into avidity and neutralization that make 007 stand out for more than just its name. (1/5)

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Online now - the Review " #Autophagy regulation by phase separation, avidity, and wetting" from @wilflinglab.bsky.social, @kraftlabfr.bsky.social and co.

#BiomolecularCondensates #PhaseSeparation #Wetting #Avidity #Theraeputics

Read it here: authors.elsevier.com/sd/article/S...

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Why are you so enchanted by this world when a mine of gold lies within you? Open your eyes and come— Return to the root of the root of your own soul. #Rumi #Avidity #RadicalAvidity

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The Sun ignites a pull to tear away from the familiar! This isn't literal gold; it's the #HolyGrail #Treasure calling to a new reality. Avidity is the engine of evolution, pushing you out of your comfort zone. #SabianSymbols #Scorpio6#SabianSymbolsRegenerated #GoldRush #HolyGrail #Chalice #Avidity

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Novartis acquires Avidity Biosciences! Novartis now has two FSHD therapies in development. "We look forward to continued progress under Novartis’s stewardship."
Read the announcement: www.fshdsociety.org/2025/10/27/novartis-acqu...

#Avidity #Novartis #FSHDResearch #FSHD

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Novartis ha acquisito la biotech Usa Avidity Biosciences L'acquisizione di Novartis rafforza la strategia nelle neuroscienze e offre l’opportunità di sviluppare terapie potenzialmente first-in-class

L'acquisizione di #Novartis rafforza la strategia nelle neuroscienze e offre l’opportunità di sviluppare terapie potenzialmente first-in-class #avidity #rna

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Novartis acquiring US firm Avidity Biosciences for $12 bn Swiss pharmaceutical giant Novartis announced Sunday it had agreed to buy Avidity Biosciences, with the San Diego-based biopharmaceutical company being valued at $12 billion. “The proposed acquisition is expected to create an industry-leading pipeline, building on the Novartis expertise in spinal muscular atrophy and commercialisation capabilities in genetic neuromuscular diseases,” Novartis said in a statement. […] The post Novartis acquiring US firm Avidity Biosciences for $12 bn appeared first on Digital Journal.
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Accurate human genome analysis with element avidity sequencing. #Sequencing #Avidity #BMCBioinformatics #Bioinformatics #Genomics @elembio.bsky.social 🧬 🖥️
bmcbioinformatics.biomedcentral.com/articles/10....

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Avidity Biosciences Prepares for Three Rare Muscle Disease Programs’ 2025 BLA Submission and Commercialization

Avidity Biosciences, Inc., a biopharmaceutical company producing Antibody Oligonucleotide Conjugates (AOC) RNA therapies, announced its progress and goals for a transformative 2025.

A biopharmaceutical firm dedicated to developing a novel class of RNA treatments known as Antibody Oligonucleotide Conjugates (AOCsTM), Avidity Biosciences, Inc., today reported its advancements and plans for a game-changing year in 2025.

These significant expected milestones include completing three potentially registrational programs, submitting a Biologics License Application (BLA) for delpacibart zotadirsen (del-zota) for individuals with Duchenne muscular dystrophy mutations amenable to exon 44 skipping (DMD44), getting ready for several product launches in DMD44, myotonic dystrophy type 1 (DM1), and facioscapulohumeral muscular dystrophy (FSHD), and establishing a completely integrated, international business to support an expanding AOC pipeline in precision cardiology and neuromuscular diseases.

Avidity Biosciences Prepares for Three Rare Muscle Disease Programs’ 2025 BLA Submission and Commercialization Avidity Biosciences, Inc., a biopharmaceutical company producing Antibody Oligonucleotide Conjugates (AOC) RNA therapies, announced its progress and goals for a transformative 2025. A biopharmaceutical firm dedicated to developing a novel class of RNA treatments known as Antibody Oligonucleotide Conjugates (AOCsTM), Avidity Biosciences, Inc., today reported its advancements and plans for a game-changing year in 2025. These significant expected milestones include completing three potentially registrational programs, submitting a Biologics License Application (BLA) for delpacibart zotadirsen (del-zota) for individuals with Duchenne muscular dystrophy mutations amenable to exon 44 skipping (DMD44), getting ready for several product launches in DMD44, myotonic dystrophy type 1 (DM1), and facioscapulohumeral muscular dystrophy (FSHD), and establishing a completely integrated, international business to support an expanding AOC pipeline in precision cardiology and neuromuscular diseases.

Avidity Biosciences Prepares for Three Rare Muscle Disease Programs’ 2025 BLA Submission and Commercialization

👉 Read More: dmdwarrior.com

#dmd #duchenne #bmd #becker #genetherapy #dmdwarrior #dmdwarriors #duchennesmusculardystrophy #duchenne #gene #dna #avidity #aviditybiosciences #raredisease

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Todays #WordOfTheDay is: Zeal
Synonyms for this word are #zeal, #enthusiasm, #passion, #fervor, #eagerness, #devotion, #ardour, #dedication, #intensity, #vigor, #fire, #avidity, #keenness, #excitement, #commitment, #determination, #fondness

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#vss365
As I picked up the helmet, my hand suddenly felt warm. I threw it down and started pulling off my gloves. I don’t know what it was but I think I got it. A loud “HEY!” got my brother’s attention to the danger. He nodded back, his #avidity for the scooter the same.

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It was a record meeting for Imperial Prostate at #BAUSOncology 2024 with presentations on prostate cancer screening, early detection, molecular imaging and discussion of many of our ongoing/upcoming trials from our fellows, lecturers, and consultants #ATLAS #AVIDITY #FLUORESCE #PACIFIC #TRANSFORM

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the infinite possibilities
of an impending fate
grip my pliant mind
weigh down my heavy heart
and temper my ardent soul
with an evershifting #avidity

#vss365

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"With #avidity?"

"Oh yes!"

#VSS365

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It wasn’t a lack of #avidity but his shyness blocked him to get off his stool, struggle through the crowded bar and tell her she just did the best karaoke ever.
#vss365 #prompt #microfiction
#writingprompt #writingcommunity

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“Florian, I acknowledge your multitude of interest and the #avidity you use in reading of things that interest you, but the Gate making people sick has been debunked, tens if not hundreds of times already.” Doctor said, but Florian just shook his head, “Propaganda!” #vss365

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Her business failed. Her passions and #avidity now ran dry. Her only solution was to move back in with her aging parents in their small town. It was beginning of a holiday movie, but without Hollywood writing the script. #vss365

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“Also, it does not baffle the science. We know what causes all these new illnesses. It is the gate travel.” Florian said, and the doctor took his glasses away. “Gate travel was deemed safe years ago.” “Statistically safe says the legal text. My #avidity knows no limits.” #vss365

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“That is not just that, but one of the new ones that still baffles science. It will feel hot on the second stage, burning on third and I hope you never reach the fourth.”“I have read about medical sciences with #avidity so I know, on fourth stage I will burst into flames.”#vss365

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“The results are as expected or even more dire. The #avidity factor is on plus five, so we know for sure it is bone fever.” Doctor Merchant said and placed the result on the table for Florian to read. “Bone fever is such a silly name. It is just a form of bone cancer.” #vss365

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As Jeff placed his hands on the wooden chair arms, the Butcher grabbed his shoulder. "Not quite yet." He squeezed a cold gel onto the back of Jeff's neck. "Skin glue. Don't bleed on my floor."

The Man in Green smiled. "Let's go put your #avidity for murder to good use. #vss365

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Each word I follow
Each thought in your minds haze
I try to think swallow
Imagination buzzes sheer #avidity
Could it be
All you poem about, is me

#vss365

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drink. die
I drink;
I die.

I religion.

I thorned my precision--
#avidity, soft sword
of your altar, I am.

mossy, drunk
deep from deep #ardour,
deep incantation,
rain-kissed incantation,
lips to your altar--

You, a lambing breath, and I:

Yours, Yours, Yours.

#vss365

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Clinical trials for Lobosium, a hair loss treatment, halted after participants experienced undesirable outcomes. Though #avidity for certain lunar phases and an allergy to semi-precious metals were considered tolerable, extreme body hair and cannibalistic urges were not.

#vss365 #vssdaily

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Simon Sugar led the children into his factory. "Everything here is candy!” he said with #avidity. “The floor, the wallpaper, even the forklift!"

A boy raised his hand. "There’s even a chocolate river outside!"

"…No, dummy, that's pollution. Did you think the sky was chocolate, too?"

#vss365 #vss

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The cat—generally placid and unconcerned about most things, in and out of her reach—pushed her cheek against my fingers with an #avidity close to zeal.
What a blessing to have an itch scratched, I thought. A need so perfectly met.
What a blessing to make demands of the world.
#vss #vss365 #writing

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#Avidity for alliteration. Always asking how to approach the astonishing while abstaining from the amoral, albeit, alluring attractions. Absurd arduous acts can affect anyone's affinity for applying themselves to what lies ahead. Don't be avaricious, be aware of your acme art. Aye?

#vss365 #writing

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Their first night in a pilgrim shelter, Lark dreamed that Drake was making love to her by a stream. They caressed with an #avidity they had rarely felt while he lived, as neither of them was hotblooded by nature.
She woke sweating, and slipped outside to calm down.

#vss365 #PromptJourney 50/?

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The #avidity with which he attacked the free buffet would make you think he hadn’t eaten anything for months. This wasn’t his first time at a casino buffet in Las Vegas, either. His wife watched him eat; said she was tired of it. Truth was they owned the casino and she loathed the place.
#vss365

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After decades of congenital lethargy, he poured all his ambition into growing and grooming the most magnificent moustache in the city.
Then his #avidity deserted him, and he lost interest. His facial hair became an important habitat for local wildlife.

#vss365

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