#CellStemCell

Hao Yin

@haoyin.bsky.social

3 months ago

A 5-day protocol to generate hiPSC 3D Vascular Organoid😎
ETV2▶️Endothelial Cell
NKX3.1▶️Mural Cell

👉Perfusable, arteriovenous network in vivo
👉⏫Reperfusion in mouse diabetic limb ischemia
👉⏫transplanted islet performance

@meleromartinlab.bsky.social #CellStemCell 2025
www.cell.com/cell-stem-ce...

@neuralstemcells.bsky.social

4 months ago

Early results from our Luxa Biotech-sponsored and #NEIfunded #ClinicalTrial are out in #CellStemCell. The trial uses an adult RPE stem cell therapy for dry age-related #MacularDegeneration.

Beautiful cover art by Dr. Yangzi Isabel Tian.

Full Text | zurl.co/gQ2bq
@cellpress.bsky.social
#NIHfunded

Aitor Aguirre, Ph.D.

@aaguirre1980.bsky.social

4 months ago

Human heart-macrophage assembloids mimic immune-cardiac interactions and enable arrhythmia disease modeling O’Hern et al. present a novel human heart-macrophage assembloid platform generated by integrating hPSC-derived embryonic monocytes into heart organoids. These tissue-resident macrophages regulate card...

Our new paper in Cell Stem Cell introduces human heart–macrophage assembloids — the first, highly sophisticated organoid model of immune–cardiac interactions.

#NAMs #Organoids #CardiacResearch #CellStemCell #AFib #NIH #MSU

Link to the paper: www.cell.com/cell-stem-ce...

Hao Yin

@haoyin.bsky.social

5 months ago

#TissueEngineeredBloodVessel

Decellularized 👤umbilical cord artery
Seeded: #hiPSC #EndothelialCell
Bioreactor trained: pulsatile unidirec flow 15➡️5 dyn/cm2

Rat #InferiorVenaCava graft▶️
0️⃣Thrombosis
Complete repop by host EC 2 wk SMC 2 mo

#CellStemCell 2025
www.sciencedirect.com/science/arti...

Matthew Alexander, PhD

@mattmuscleguy.bsky.social

9 months ago

Multiomic profiling reveals that prostaglandin E2 reverses aged muscle stem cell dysfunction, leading to increased regeneration and strength Wang et al. uncover that aged muscle stem cells have blunted PGE2-EP4 signaling that is critical for their regenerative function. Treatment with exogenous PGE2 reverses age-related defects in muscle s...

New #CellStemCell paper from Helen Blau and colleagues: Multiomic profiling reveals that prostaglandin E2 reverses aged muscle stem cell dysfunction, leading to increased regeneration and strength. #Myoblue tinyurl.com/yvf4cdch

Felipe Martínez-Ramírez

@felipinmtzrmz.bsky.social

1 year ago

Adult bi-paternal offspring generated through direct modification of imprinted genes in mammals Li and colleagues successfully generated bi-paternal mice that developed to adulthood by targeting 20 key imprinted loci. This study underscores imprinting gene abnormalities as the primary barrier to...

🧬 BREAKTHROUGH: Scientists leap forward with bi-paternal offspring!🐭 Surviving to adulthood, this genetic advance could reshape research & medicine overcoming developmental challenges. 🚀 #Science #Genetics #CellStemCell #trends #PhDlife #innovation #ScienceBreakthrough

www.cell.com/cell-stem-ce...

DrawImpacts

@drawimpacts.bsky.social

1 year ago

🎉 Happy New Year from #DrawImpacts Studio! 🎨
We’re thrilled to kick off 2025 with exciting news: our first cover of the year has been selected for #CellStemCell 's first issue of 2025!! To another year of impactful collaborations, science, and creativity—we can’t wait to see what this year brings! 🌟

Vijay G. Sankaran

@bloodgenes.bsky.social

1 year ago

Delighted to have our work led by #RichardVoit
from our group featured on the cover of #CellStemCell
today. Artwork by the amazing
@drawimpacts.bsky.social:

www.cell.com/cell-stem-ce...

Stay tuned as we work on initiating a clinical trial for this approach!

Hao Yin

@haoyin.bsky.social

1 year ago

#SpatialTranscriptomics #Visium
Human Healthy Skin Wound Healing (This is a Human Trial!🥸 N=7)
D0/1/7/30

Angiogenic niche comprising #EndothelialCell Fibroblast Mφ

Mφ secretome
D1 (inflam) IL1A/B CCL7
D7 (prolif) TGFB C1QB
D30 (remodeling) IGF1 C1QB

#CellStemCell 2024
www.cell.com/cell-stem-ce...

Hao Yin

@haoyin.bsky.social

1 year ago

hiPSC-derived venous #EndothelialCell #iVEC

Mesoderm progenitors+VEGFA+FGF2+RA+DAPT

MEF2C as a putative venous endothelial TF

Retain EphB4 venous marker in vivo

Modeling TIE2L914F #VenousMalformation
DRUG-seq #DeepLearning➡️Bosutinib

#CellStemCell 2024
www.sciencedirect.com/science/arti...

Alex Lercher

@alercher.bsky.social

1 year ago

Chronic autoimmunity rewires metabolism in progenitors, correlating with innate immune memory formation in macrophages that increases antibacterial activity but might also aggravate autoimmune diseases?
shorturl.at/SZ1Ww

#CellStemCell