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Really pleased to share the *final* version of @katiegelder.bsky.social's super work, profiling the functional roles of #IDRs in CBP. Published today 🎉

🔗https://doi.org/10.1016/j.celrep.2026.117109

#IDRs #condensates #transcription #CBP #generegulation #enhancers (1/7)

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Thanks for having me @danbose.bsky.social, I had such a wonderful time! Lots of cool questions & great to hear about the exciting research on #condensates and #generegulation @sheffielduni.bsky.social!

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Fantastic to welcome @fariatrypslab.bsky.social for our @mcb-sheffield.bsky.social seminar today. So much cool work on #condensates and #generegulation, and can't get over how awesome #trypanosomes are!

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Membrane-protein-mediated phase separation orchestrates organelle contact sites Hoffmann, Nagao, et al. show that PDZD8, an endoplasmic reticulum (ER) membrane contact site protein, forms liquid-like condensates through its intrinsically disordered region. These condensates media...

What if organelles where glued together by #condensates ?

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The whole workshop has been well organised and super interesting, I have taken a lot of inspiration away from the talks so far and I am excited to for the rest of the day/week. (2/3) #MembraneTrafficking #Organelles #Mechanobiology #Condensates

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How does molecular valency shape condensate assembly and function? We used the CO2-fixing organelle in algae—the pyrenoid—to find out… 🧵

Preprint here!:
www.biorxiv.org/content/10.6...

@cellarchlab.com @phaips.vd.st @biologyatyork.bsky.social
#Rubisco #PhaseSeparation #Condensates #Pyrenoid

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We’re hiring a PDRA and a technician!
If you’re passionate about #parasites #genomes #condensates then this project is for you! Help us decode the role of nuclear architecture in gene expression regulation in #Leishmania alongside the @mottramlab.bsky.social @york.ac.uk @ybri-uoy.bsky.social

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Seriously some of the most fun I’ve had in this field so far! 🥳🥳 #kitp #roadmap #condensates

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Really valuable #preprint on biological #condensates, with some welcome terminological clarity:“Some papers equate condensates with #LLPS, but it is often neither clear whether the involved objects have liquid-like properties…nor whether they actually form by phase separation.”👏👇

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📰Check out our series of Issues thematically aligned with the expertise of our academic editors

Explore the 'In the Limelight' series
🔦https://buff.ly/4b4aRkm

#AlzheimersDisease #RNAbiology #Glycosphingolipids #Neurotransmitter #Antivirals #Lysosomes #Condensates #Bioplastics

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Original post on mastodon.social

"These results have broad implications for biological processes regulated by membrane potential, particularly in contexts such as neuronal signaling, where condensate interactions with membranes may play a previously unrecognized regulatory role."

#neuron #condensates #cellMembrane […]

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2025-12-08: “Drugging Condensates & Drug Discovery” Dewpoint workshop – ComeInCell

Next Monday, 8 Dec at 2 pm CET (Berlin time), join a 2h online lecture on drug development involving biomolecular #condensates by Dr. Diana Mitrea (Dewpoint Therapeutics) & organized by @comeincell.bsky.social

🔗 info & registration:
tinyurl.com/3xsd9tmu

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Events (Jul – Dec 2025) – ComeInCell

Monday blues no more with these online events by @comeincell.bsky.social (coordination: @dimovalab.bsky.social)

· 8 Dec, 2pm CET: “Drugging #Condensates & Drug Discovery” Dewpoint workshop

· 15 Dec 2pm CET: “Life in #Biotech” Dewpoint workshop

tinyurl.com/39rpaf84
#CellBiology #Biophysics

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🌟G&D SPOTLIGHT 🌟

REVIEW: RNA granules: functional compartments or incidental condensates?
By Andrea Putnam, Laura Thomas and Geraldine Seydoux
➡️ https://genesdev.cshlp.org/content/37/9-10/354.abstract

#RNAmetabolism #RNAgranules #phaseseparation #RiboNucleoProteins #condensates

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Hierarchical interactions between nucleolar and heterochromatin condensates are mediated by a dual-affinity protein - Nature Cell Biology Rajshekar et al. show that a hierarchy of affinities layers pericentromeric heterochromatin around nucleoli, with the RNA helicase Pitchoune (DDX18) acting as a key dual-affinity linker in Drosophila ...

Hierarchical interactions between nucleolar and heterochromatin condensates are mediated by a dual-affinity protein #condensates #chromatin
www.nature.com/articles/s41...

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puzzle pieces are connected to represent CD-CODE database concept. landscape orientation (4 puzzle pieces top row, 5 puzzle pieces lower row). Top row: puzzles representing applicability, API, infectious condensate with logo representing pathogen cell and condensate, condensatopathies with a stethoscope logo, text: CD-CODE CrowDSourcing Condensate Database and Encyclopedia. Bottom tow: puzzles representing community, CD-CODE logo, Biomolecualr condensates with logos for species (human, frog, mouse), c-mods with chemical compound logo, DNA, proteins, RNA minimalistic logos.

puzzle pieces are connected to represent CD-CODE database concept. landscape orientation (4 puzzle pieces top row, 5 puzzle pieces lower row). Top row: puzzles representing applicability, API, infectious condensate with logo representing pathogen cell and condensate, condensatopathies with a stethoscope logo, text: CD-CODE CrowDSourcing Condensate Database and Encyclopedia. Bottom tow: puzzles representing community, CD-CODE logo, Biomolecualr condensates with logos for species (human, frog, mouse), c-mods with chemical compound logo, DNA, proteins, RNA minimalistic logos.

CD-CODE 2.0 is now published in @narjournal.bsky.social 🤩
CD-CODE 2.0 stores #biomolecular #condensates and their #protein and nucleic acid components and now includes repository of 🦠 infectious condensates, 💊 condensate-modulating compounds, and 🩺 condensatopathies
👀 doi.org/10.1093/nar/...

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Nanoscale domains govern local diffusion and ageing within fused-in-sarcoma condensates - Nature Nanotechnology Single-molecule tracking reveals nanoscale domains within fused-in-sarcoma condensates. These nanodomains migrate to the condensate surface during ageing, seeding amyotrophic lateral sclerosis-linked ...

New paper: Nanoscale domains govern local diffusion and ageing within fused-in-sarcoma condensates

Single-molecule tracking reveals nanoscale domains within #FUS #condensates that migrate to the condensate surface during ageing, seeding #ALS fibrils.

www.nature.com/articles/s41...

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Many thanks #AntonioCostaFilho for the kind invitation to participate in the pre-meeting #SBBf course “Phase separation at membrane interphases: Biomolecular condensates in Actions”. Happy share session with #RumianaDimova #Condensates #LLPS #Bioimaging #Phasors #DANprobes

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So proud of Chris Ng who successfully defended his PhD thesis recently!! Thank you to his examiners Alex Borodavka & Paolo Arosio. It’s been such a fun journey and we wish Chris great success with his new job ❤️ @lauraitzhaki.bsky.social @phar.cam.ac.uk #biomolecular #condensates

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@science.org ATP-dependent remodeling of #chromatin #condensates reveals distinct #mesoscale outcomes | Science www.science.org/doi/10.1126/...

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Attention colleagues! Interested in an interdisciplinary #PhD? 🧬 Apply now for one of 12 PhD positions exploring biomolecular #condensates! This program involves several PoL PIs, bridging the gap between physics and biology.

Apply here: dresdencondensates.org/join-us/
🗓Deadline: 24. October

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🤩 We are delighted that Sheena Mali has joined #ComeInCell! She will be working in Di Michele’s lab in the UK. Her project will focus on engineering interactions between #syntheticRNA #condensates and #cellmembranes. More details: www.comeincell.org/dc17-sculpti...

Welcome, Sheena! #HorizonEurope

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Check out our latest, where we investigate the molecular origin of differences between Lys and Arg and their roles in biomolecular #condensates

@dipcehu.bsky.social

www.biorxiv.org/content/10.1...

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Visualizing nuclear structures often recognizable in electronmicroscopy imaging for chromatin. Nice.
@danfengcai.bsky.social #bodies #nucleus #dynamic #condensates #geneexpression www.biorxiv.org/content/10.1...

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Come and hear about our latest story! It's a really nice series as well- sign up for the mailing list for updates #condensates #UKcondensates

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(2/3) We will use #Computation and #Theory to study the dynamics of #Inflammation, and the organization of #Chromatin and #Condensates in the cell nucleus. Official job ads soon to come. Interested in discussing these topics and the role of mechanics? Let’s talk: andriy@goychuk.me

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For our 25@25 series, @jerelleaj.bsky.social talks about how she uses computational approaches to understand the role of biomolecular condensates in cells & what happens when they are disrupted.

#chemistry #condensates #gatescambridge25

@uniofcam.bsky.social @gatesfoundation.bsky.social

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1/3 📢 New work from our lab 📢 We uncover a unifying dielectric principle for biomolecular condensates! 💦Contrary to intuition, we find that it is not a condensate’s absolute polarity, but the permittivity contrast with its surroundings, that governs its affinity for membranes. #GUV #condensates

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More generally, this work extends beyond functional studies in cells to support the relevance of biomolecular #condensates in mammalian #physiology, while hinting @ intriguing connections between condensates & public health. 11/

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New work from the lab: Identification of CNOT1-CCR4-NOT as a suppressor of 53BP1-p53-p21 signaling @cp-cellreports.bsky.social. Congratulations to first author Antonio Galarreta and to all co-authors. www.cell.com/cell-reports.... #Microscopy #RNAiScreen #Condensates

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