#ERAD

Signal Transduction and Targeted Therapy

@sigtrans-sttt.bsky.social

2 months ago

Reviewing the molecular mechanisms governing protein quality & quantity control by #ERAD, its integration with the #UPR and #ERphagy, while highlighting its physio-/pathological implications and strategies for ERAD-related diseases. #medsky

#STTT #OpenAccess: doi.org/10.1038/s413...

@arxivlens.bsky.social

2 months ago

Induced ubiquitination bypasses canonical ERAD to drive ER protein degradation
Deol, K. K. et al.
Paper
Details
#ERAD #Ubiquitination #ProteinDegradation

Diagnostic Imaging

@dximaging-mjh.bsky.social

3 months ago

Video: Are Head CT Scans Overutilized in Emergency Departments?
www.diagnosticimaging.com/view/are-hea...
#radiology #neuroradiology #ERad #CTRad

🧦die_heike 🦋 (Ringel🧦Ära🎄& PinkyModus 🎸)

@dieheike.bsky.social

4 months ago

Wg euch wurde ich blockiert! #schmolllippchenzieh #ERAD!

Ling Qi

@qilabuva.bsky.social

8 months ago

🚨 New review alert! Our article "SEL1L–HRD1-mediated ERAD in mammals" is now online at Nature Cell Biology. We explore how this central ERAD pathway maintains protein homeostasis in mammals and why it matters for health and disease.

👉 rdcu.be/etk3b

#ERAD #NatureCellBiology #SEL1L #HRD1 #ER

American Society for Cell Biology

@ascbiology.bsky.social

9 months ago

Microtubules do more than move chromosomes—they help clean up cellular messes too. 🧹 Eric Rubenstein of Ball State University shows Kar3 and Vik1 are key to protein quality control via ER-associated degradation.
📖 www.molbiolcell.org/doi/10.1091/... #ASCB #CellBiology #ERAD #Proteostasis

Rebsamen Lab @UNIL

@rebsamenlab.bsky.social

1 year ago

Indeed, without CCDC134, Gp96 is hyperglycosylated and undergoes #ERAD degradation, so TLRs cannot be well-folded nor traffic to their corresponding membranes for pathogen detection and signalling.