#FTLD

Sjors Scheres

@sjorsscheres.bsky.social

2 months ago

Oh wow: Cryo-EM structure of #TAF15 filaments from postmortem #FTLD brains by the group of Ben Ryskeldi-Falcon at the @mrclmb.bsky.social. What an amazing tour-de-force!! 🤯

www.biorxiv.org/content/10.6...

FRONTIER Research Group

@frontier-usyd.bsky.social

2 months ago

Our 2025 group photo. Big smiles, big plans for the year ahead.

#frontotemporaldementia #primaryprogressiveaphasia #ftd #ftld #ppa #endFTD

@brainandmindcentre.bsky.social
@sydney.edu.au

Dr Martina Bocchetta

@drmbocchetta.bsky.social

5 months ago

Neuroanatomical normative modelling in frontotemporal lobar degeneration: higher heterogeneity in the behavioural variant - Journal of Neurology Introduction Frontotemporal lobar degeneration (FTLD) includes heterogenous diseases: behavioural variant frontotemporal dementia (bvFTD), primary progressive aphasias (PPA), progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS). We applied neuroanatomical normative modelling to quantify individual atrophy patterns and heterogeneity within and between FTLD forms. Methods We included 160 participants across FTLDNI and 4RTNI studies: controls (n = 15), bvFTD (n = 22), nfvPPA (n = 14), svPPA (n = 21), CBS (n = 43) and PSP (n = 45). Using cortical thickness and subcortical volumes from 3T MRIs, we applied normative modelling with a large healthy reference dataset (n = 58,836), further accounting for age, sex, and scanner. Outlier regions (z < – 1.96) were used to compute total outlier counts (tOC) and Hamming distances, capturing individual atrophy patterns and inter-subject dissimilarity. Results bvFTD, svPPA, CBS and PSP showed significantly higher cortical tOC than controls, with all groups showing higher subcortical tOC than controls, especially svPPA and PSP. bvFTD, svPPA, CBS and PSP had significantly higher cortical Hamming distance scores than controls, with higher scores in bvFTD and svPPA than nfvPPA and PSP. svPPA and PSP had significantly higher subcortical scores than controls and CBS. Greater disease severity (measured using the Clinical Dementia Rating—CDR for PSP and CBS, and the CDR® plus NACC-FTLD global scores for FTD variants) was associated with increased tOC and dissimilarity, highlighting the link between clinical progression and neuroanatomical heterogeneity. Conclusions The pronounced heterogeneity within and between FTLD subtypes (particularly in bvFTD) increases with disease progression and may reflect distinct underlying pathologies. This supports the development of subtype-specific biomarkers and emphasize the need for personalized diagnostic and therapeutic strategies.

Normative neuroanatomical modelling to quantify individual 🧠atrophy patterns in #FTLD - results from this UCL and Brunel collaboration are now out: link.springer.com/article/10.1...

Conceicao Bettencourt

@saobettencourt.bsky.social

8 months ago

🚨New publication alert from the #BettencourtLab! Naiomi Rambarack's first first-author paper 👏 :
#DNAmethylation #dysregulation of #STX6 and other #FTLD #genetic risk-associated loci".

#Dementia

Big thanks to all contributors and funders!
@alzheimersresearchuk.org

rdcu.be/euZmw

Molecular Neurodegeneration

@molneurodegen.bsky.social

8 months ago

Methylome analysis of FTLD patients with TDP-43 pathology identifies epigenetic signatures specific to pathological subtypes - Molecular Neurodegeneration Background In the last decade, the importance of DNA methylation in the functioning of the central nervous system has been highlighted through associations between methylation changes and differential...

Methylome analysis of #FTLD patients with #TDP43 pathology identifies #epigenetic signatures specific to pathological subtypes

Cristina T. Vicente, Tejasvi Niranjan, Elise Coopman...Rosa Rademakers @viblifesciences.bsky.social

molecularneurodegeneration.biomedcentral.com/articles/10....

@tnrlab.bsky.social

10 months ago

Repositioning of polyubiquitin alters the pathologic tau filament structure Structurally diverse tau filaments form proteinaceous aggregates in a heterogeneous group of neurodegenerative diseases called tauopathies1. The factors extrinsic to the highly ordered core structure ...

My first Bluesky post!
We found that shifting around polyubiquitin (using a chemical biology trick) results in altered #tau filament structure. The unstructured "fuzzy coat" of tau filaments matters!?! #AD #FTD #FTLD #cryoEM #Alzheimer #VCP #raredisease

www.biorxiv.org/content/10.1...

@drtanakabluesky.bsky.social

10 months ago

She forgot her son’s name👵 #Alzheimer’s? #FTLD? 🧠💔Old scans gave no answers—until [¹¹C]PBB3 #PET/CT revealed #tau buildup🧬🧪📊driving the decline🌫️🤔🧠A new tool for clear, early diagnosis 🔍⚡ @mdpiopenaccess.bsky.social #Neuroscience #PETCT #BrainHealth 🧠💡
doi.org/10.3390/biom...

@drtanakabluesky.bsky.social

11 months ago

She forgot her son’s name👵 #Alzheimer’s? #FTLD? 🧠💔Old scans gave no answers—until [¹¹C]PBB3 #PET/CT revealed #tau buildup🧬🧪📊driving the decline🌫️🤔🧠A new tool for clear, early diagnosis 🔍⚡ @mdpiopenaccess.bsky.social #Neuroscience #PETCT #BrainHealth 🧠💡
doi.org/10.3390/biom...

@prudenciolab.bsky.social

11 months ago

Our manuscript got highlighted with a beautiful infographic!

#TDP43 #PerrySyndrome #Neurodegeneration #RNAsplicing #Biomarkers #Neuroscience #FTLD #ALS #PrudencioLab

DOI: lnkd.in/eXr8te8A

@drtanakabluesky.bsky.social

11 months ago

She forgot her son’s name👵 #Alzheimer’s? #FTLD? 🧠💔Old scans gave no answers—until [¹¹C]PBB3 #PET/CT revealed #tau buildup🧬🧪📊driving the decline🌫️🤔🧠A new tool for clear, early diagnosis 🔍⚡ @mdpiopenaccess.bsky.social Biomedicines #Neuroscience #PETCT #BrainHealth 🧠💡
doi.org/10.3390/biom...

@drtanakabluesky.bsky.social

11 months ago

She forgot her son’s name👵 #Alzheimer’s? #FTLD? 🧠💔Old scans gave no answers—until [¹¹C]PBB3 #PET/CT revealed #tau buildup🧬🧪📊driving the decline🌫️🤔🧠A new tool for clear, early diagnosis 🔍⚡ @mdpiopenaccess.bsky.social Biomedicines #Neuroscience #PETCT #BrainHealth 🧠💡
doi.org/10.3390/biom...

Conceicao Bettencourt

@saobettencourt.bsky.social

1 year ago

DNA methylation as a contributor to dysregulation of STX6 and other frontotemporal lobar degeneration genetic risk-associated loci Frontotemporal Lobar Degeneration (FTLD) represents a spectrum of clinically, genetically, and pathologically heterogeneous neurodegenerative disorders characterised by progressive atrophy of the fron...

🚨 New preprint from the #BettencourtLab by Rambarack et al 👇.
#epigenetics #DNAmethylation #FTD #PSP #FTLD #dementia

Philip McMinn Mitchell

@hcluganda.bsky.social

1 year ago

#carers #dementia #svPPA #FTD #FTLD #aphasia

Dr Aida Suarez Gonzalez

@aidasuarez.bsky.social

3 years ago

🚨Incidence of #FTLD in Europe🇪🇺: https://dir.lat/wFemg7

🔶 annual incidence rate: 2.36/100,000 p-y
🔶 incidence higher among men (2.84 vs 1.91 women)
🔶 bvFTD: most common phenotype (40% all cases)
🔶 PPA: 28% of all cases
🔶 extrapyramidal...