Drosophila juvenile brain labeled for astrocyte-like glia and ensheathing glia. Spatial organization of astrocyte-like glia (right) and ensheathing glia (left) subclasses. These two glial populations sculpt brain circuit architecture, with coordinated activities in mediating critical period experience-dependent connectivity remodeling. Together, these glial subclasses provide a cellular mechanism for synapse pruning in response to experience that shapes circuitry in development and can re-open plasticity at maturity. Image Creator: Vanessa Miller
A previous @plosbiology.org study showed that #synapse elimination in a #Drosophila brain circuit depends on #glial #serotonergic signaling. This new study shows that serotonin coordinates 2 distinct classes of #glia, with MMP-1 acting downstream of 5-HT2AR activation 🧪 plos.io/48oSY00