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Proanthocyanidins enhance antitumor immunity by promoting ubiquitin-proteasomal PD-L1 degradation via stabilization of #LKB1 and SYVN1 www.jci.org/articles/vie...
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#LKB1
Latest posts tagged with #LKB1 on Bluesky
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Posts tagged #LKB1
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Authors combined targeted NGS with STAS and LVI scoring and organ-specific metastasis profiling within a single well-defined NSCLC cohort. This design allows them to directly link #STK11 mutation subtypes with distinct clinical and metastatic phenotypes. #LKB1
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This review highlights the role of #LKB1 in #Tumorigenesis and its therapeutic relevance in #Oncology, offering new insights into targeted #CancerTherapy. @westernu.bsky.social #medsky
#OpenAccess: www.sciencedirect.com/science/arti...
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Clinical data from lung adenocarcinoma patients with KRASG12C and #STK11 #LKB1 mutations were analyzed, looking for correlation between high squamous gene signature at baseline and response to adagrasib. Analysis reveals patients with a high squamous gene signature had poorer responses to treatment.
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#LKB1 mutation (shown by green fluorescent protein) in lung cancer #metastasis. Beautiful image. Red = Actin. Cell nuclei in blue. 😍
Credit: National Cancer Institute / Winship Cancer Institute of Emory University / Science Photo Library @winshipatemory.bsky.social
#STK11
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Targeting mTOR and Glycolysis in HER2-Positive Breast Cancer
If LKB1 is removed (or "knocked out"), the activation of #AMPK by PKA is significantly reduced. However, even without #LKB1 ( #STK11 ), there is still some activation of AMPK.
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The research found that high expression levels of certain genes associated with #LKB1 signaling, such as #AMPK, #LYK5, and #PAK1, correlated with improved survival rates across all breast cancer types studied.
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Different breast cancer subtypes respond differently to #LKB1 signaling. For instance, while some genes like #PAK1 and #SIK2 are linked to improved survival in Triple-Negative Breast Cancer (TNBC) before chemotherapy, their impact changes after treatment.
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Authors evaluated #LKB1 signaling pathway gene expression associations with patient survival in overall breast cancer, specific subtypes, as well as pre- and post-chemotherapy.
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Understanding the metabolic consequences of #LKB1 inactivation could provide critical insights for developing targeted therapies in this #cancer type
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Given that current immune checkpoint inhibitors (ICIs) are less effective in patients with #LKB1 and #KEAP1 mutations, there is a pressing need for new treatment approaches. This paper suggests that combining ICIs with therapies targeting metabolic pathways could improve outcomes for these patients.
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www.sciencedirect.com/science/arti...
Targeting telomerase could be a viable strategy in cancer treatment. This could lead to the development of new drugs that specifically inhibit telomerase in lung cancer cells 🤔 #LKB1
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