Starting off our March 2026 issue of #JLB - "Sirtuin 1 is an endogenous #NETosis inhibitor that becomes dysfunctional in #Diabetes" by Liang De Wang & colleagues
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#NETosis
Latest posts tagged with #NETosis on Bluesky
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#Ukraine Conflict
#U.S. Foreign Policy
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#AEW Collision
#Six Nations
#Newcastle United
#Arsenal vs Everton
Posts tagged #NETosis
Excited to share our latest #review on how the mechanobiology of the nucleus impacts immune cell function, including #NETosis, #migration, and #differentiation.
doi.org/10.1080/1949...
This was a fantastic collaborative effort with @hawa-racine.bsky.social, along with Sarah & Janina from our lab!
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This may reduce the production of cross-reactive antibodies (CR Abs) that contribute to pathological inflammation & #NETosis
link.springer.com/article/10.1...
Immunosuppression, such as in HIV infection,
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Multi-omics evidence shows alcohol aggravates #EpilepticSeizures via the MPO-driven #NETosis pathway, highlighting a promising therapeutic target in alcohol-related #Epilepsy. #medsky
#OpenAccess: www.sciencedirect.com/science/arti...
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We look forward to hearing feedback from the community on our #preprint where we used #NETosis as a platform to show that chromatin decompaction inside the nucleus directly regulates cell mechanics. This work identifies long-range biophysical impacts of chromatin in mammalian cells.
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#Cytokines released by activated immune cells can induce #NETosis, while NETs themselves further fuel the inflammatory response and autoantibody production, which can perpetuate NET formation
www.frontiersin.org/journals/med...
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(e.g., myeloperoxidase-DNA complexes) have been found in both acute & LC patients, indicating an incomplete resolution of #NETosis after the initial infection , prolonged NET formation contributes to the chronic inflammation, immunothrombosis (micro-clots) & vascular damage .
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Studies on AD pathology show a significant overlap with the inflammatory mechanisms seen in #longCOVID, including the roles of #neutrophils & #NETosis.
www.frontiersin.org/journals/neu...
link.springer.com/article/10.1...
www.frontiersin.org/journals/imm...
pubmed.ncbi.nlm.nih.gov/40474772/
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Scheme of how NETosis works. Neutrophils contain many granules that are filled with bactericidal enzymes. Once the cells are stimulated by the presence of pathogens, these granules release their content to the extracellular space, but also into the nucleus. Inside the nucleus, MPO and other factors lead to decondensation of chromatin, i.e. eviction of nucleosomes. The nucleus disintegrates and subsequently, the neutrophil bursts open and releases the decondensed chromatin to the extracellular space. There the NET can entrap the pathogen. As NETs are functionalized with bactericidal enzymes, they can directly kill pathogens they contact.
During #NETosis, neutrophils decondense their #chromatin by disassembling #nucleosomes. Then, their nucleus breaks down and the cells burst open. The decondensed chomatin then forms the NET.
As #NETs are sticky and functionalised with bactericidal enzymes, they can trap and kill bacteria.
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Just out in Infection and Immunity!
Our latest review explores how neutrophils balance antimicrobial defense with tissue protection during infection, with a focus on metabolic signaling and NETs.
Read it here: journals.asm.org/doi/full/10....
#neutrophils #immunometabolism #NETosis #hostpathogen
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Mitochondria sense bacterial lactate & drive release of neutrophil extracellular traps.
Neutrophil #mitochondria sense metabolic perturbations in the phagosome.
Accumulation of bacterial #lactate is a metabolic danger signal triggering #NETosis.
www.cell.com/cell-host-mi... #ImmunoSky #MicroSky
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VolitionRx Launches Innovative Model for Real-Time NETosis Study in Sepsis Treatment #United_States #Henderson #VolitionRx #sepsis #NETosis
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COVID Metformine netosis
As a Health Journalist @greennoise.bsky.social, have you investigated the most accessible drugs that can PREVENT the CAUSE of microthrombosis in COVID (namely, the formation of neutrophil extracellular traps)?
Did you ask MDs why they did not take any action against the risk of #netosis in #covid19?
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