Latest posts tagged with #ProteinAggregation on Bluesky
What if the real #breakthrough isn’t stopping #ProteinAggregation, but intelligently redirecting its pathway? Explore the insightful review: doi.org/10.63654/icm... #Sustainable #TherapeuticInnovation #AmyloidAggregation #ProteinMisfolding #ComputationalBiology #NeurodegenerativeDiseases
Designer foldamers are helping researchers map how α-Synuclein forms toxic aggregates in Parkinson’s Disease.
By identifying the regions that drive harmful clustering, new therapeutic targets are emerging.
t.ly/OKx34
#ParkinsonsResearch #ProteinAggregation #rPeptide
New research maps how #BetaAmyloid 1-40 aggregates over time, showing how factors like temperature shape fibril formation in Alzheimer’s disease.
#rPeptide Beta-Amyloid 1-40 (A-1001) was used to track aggregation kinetics and morphology.
t.ly/d4COq
#Neuroscience #Alzheimers #ProteinAggregation
#Review in #MedComm
Parkinson's Disease: The Epidemiology, Risk Factors, Molecular Pathogenesis, Prevention, and Therapy doi.org/10.1002/mco2...
#α_synuclein #BloodTransfusion #Gut_brainAxis #ProteinAggregation #ParkinsonsDisease #PD
New research shows coumarin-based small molecules can slow Tau and Alpha-Synuclein aggregation — a potential path for early AD/PD intervention. Tested using rPeptide’s recombinant proteins (S-1001, T-1001).
t.ly/KGkxl
#NeuroScience #AD #PD #ProteinAggregation #rPeptide
Model for RQC impacts on aging in aneuploid cells. Healthy cells maintain ubiquitin stasis as part of the Ubiquitin-Proteasome System (UPS). We propose that defects in RQC either produce or indirectly cause protein aggregates that sequester ubiquitin, thereby depleting the pool of accessible ubiquitin,
Why do disorders caused by chromosomal #aneuploidy, like #DownSyndrome, involve premature #aging? This study shows that #chromosome amplification in yeast causes defects in the #ribosomeQC pathway, leading to #ProteinAggregation & aging @plosbiology.org 🧪 plos.io/4rliUT0
Model for RQC impacts on aging in aneuploid cells. Healthy cells maintain ubiquitin stasis as part of the Ubiquitin-Proteasome System (UPS). We propose that defects in RQC either produce or indirectly cause protein aggregates that sequester ubiquitin, thereby depleting the pool of accessible ubiquitin,
Why do disorders caused by chromosomal #aneuploidy, like #DownSyndrome, involve premature #aging? This study shows that #chromosome amplification in yeast causes defects in the #ribosomeQC pathway, leading to #ProteinAggregation & aging @plosbiology.org 🧪 plos.io/4rliUT0
Model for RQC impacts on aging in aneuploid cells. Healthy cells maintain ubiquitin stasis as part of the Ubiquitin-Proteasome System (UPS). We propose that defects in RQC either produce or indirectly cause protein aggregates that sequester ubiquitin, thereby depleting the pool of accessible ubiquitin,
Why do disorders caused by chromosome amplification, like #DownSyndrome, involve premature #aging? This study shows that #chromosome amplification in yeast causes defects in the #ribosomeQC pathway, leading to #ProteinAggregation & aging @plosbiology.org 🧪 plos.io/4rliUT0
In Jan 2026 we will organize the 3rd Dutch protein aggregation network (DPAN) symposium in Amsterdam: we invite Dutch researchers interested in (disease-related) protein aggregation to join the meeting! Registration and other info: dpan-nl.org/3rd-dpan-sym... #amyloid #proteinaggregation
Aggregation dynamics of a 150 kDa Aβ42 oligomer: Insights from cryo electron microscopy and multimodal analysis. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2024.11.024
🔗 Aggregation dynamics of a 150 kDa Aβ42 oligomer: Insights from cryo electron microscopy and multimodal analysis. Computational and Structural Biotechnology Journal, doi.org/10.1016/j.cs...
📚 CSBJ: www.csbj.org
#CryoEM #ProteinAggregation #Biophysics #StructuralBiology #Alzheimers #Neuroscience
Our group presented our work at the New Horizons in Neurodegeneration 2025 (NHND 2025) in Leuven/Brussels 🇧🇪.
Pictured: our student Ihor Kozlov at the conference venue. Great discussions and inspiring science! #NHND2025 #neuroscience #proteinaggregation #research
Fluorescent 'Zoom Lens' Detects Early Protein Changes Linked to Disease
Rice University created AnapTh, a fluorescent amino acid probe that detects micro‑environment shifts in live cells, showing early aggregation hotspots (Sept 10 2025). Read more: getnews.me/fluorescent-zoom-lens-de... #proteinaggregation #nanoprobes
Ambroxol displaces α-synuclein from the membrane and inhibits the formation of early protein-lipid coaggregates
Carles, E., Dreier, J. E. et al.
Paper
Details
#AmbroxolResearch #NeurodegenerativeDiseases #ProteinAggregation
HAPLN2 forms aggregate-like structures in the cerebellar white matter of aged mice. Top: Representative images of fluorescence immunohistochemistry of the mouse cerebellum showing HAPLN2, myelin basic protein (MBP, a marker for myelinated axons), and 4′,6-diamidino-2-phenylindole (DAPI). n = 3. Bottom: Magnified fluorescence immunohistochemistry images for HAPLN2 corresponding to the boxed areas in the left panels. n = 3.
#ProteinAggregation is a hallmark of #neurodegeneration. This study shows that HAPLN2 aggregates in the aging brain, triggering #inflammation; microglial clearance regulates HAPLN2 buildup. This links protein accumulation to immune activation in healthy #aging @plosbiology.org 🧪 plos.io/4fJy7YG
HAPLN2 forms aggregate-like structures in the cerebellar white matter of aged mice. Top: Representative images of fluorescence immunohistochemistry of the mouse cerebellum showing HAPLN2, myelin basic protein (MBP, a marker for myelinated axons), and 4′,6-diamidino-2-phenylindole (DAPI). n = 3. Bottom: Magnified fluorescence immunohistochemistry images for HAPLN2 corresponding to the boxed areas in the left panels. n = 3.
#ProteinAggregation is a hallmark of #neurodegeneration. This study shows that HAPLN2 aggregates in the aging brain, triggering #inflammation; microglial clearance regulates HAPLN2 buildup. This links protein accumulation to immune activation in healthy #aging @plosbiology.org 🧪 plos.io/4fJy7YG
HAPLN2 forms aggregate-like structures in the cerebellar white matter of aged mice. Top: Representative images of fluorescence immunohistochemistry of the mouse cerebellum showing HAPLN2, myelin basic protein (MBP, a marker for myelinated axons), and 4′,6-diamidino-2-phenylindole (DAPI). n = 3. Bottom: Magnified fluorescence immunohistochemistry images for HAPLN2 corresponding to the boxed areas in the left panels. n = 3.
#ProteinAggregation is a hallmark of #neurodegeneration. This study shows that HAPLN2 aggregates in the aging brain, triggering #inflammation; microglial clearance regulates HAPLN2 buildup. This links protein accumulation to immune activation in healthy #aging @plosbiology.org 🧪 plos.io/4fJy7YG
What separates harmless from harmful protein aggregates? A recent study in The FASEB Journal links changes in PABPN1 structure to muscle cell dysfunction in OPMD—highlighting key differences between wild-type and expanded variants.
🔗 buff.ly/i34Ot9v
#MuscleBiology #ProteinAggregation #FASEBJournal
AI learns the language of sticky proteins. A breakthrough for Alzheimer’s, biotech, and beyond. #AIinBiotech #ProteinAggregation #Neurodegeneration
🙌 Huge thanks to all authors, and to Phospho Biomedical Animation for the stunning cover!
📚 Full issue: pubs.acs.org/toc/jacsat/1...
📄 Paper: pubs.acs.org/doi/10.1021/...
@radford-lab.bsky.social @naranson.bsky.social
#amyloid #chemsky #diabetes #proteinaggregation
(6/6)
It was a pleasure to host Prof. Dr. Paolo Arosio from @ethzurich.bsky.social, who gave a fascinating talk on "Engineering Enzymatic Reactions and Protein Aggregation with Biomolecular Condensates." #BiomolecularCondensates #PhaseSeparation #EnzymaticReactions #ProteinAggregation
Our first article on proinsulin proteostasis from ETSU. 😊
www.frontiersin.org/journals/mol...
Testament to great efforts by undergraduate students in my lab! 🙋🏻♂️
#proteinfolding #diabetes #proteinaggregation #insulin #proinsulin #ERqualitycontrol #proteostasis
Online now - the Spotlight "Balancing act: lipid-to-protein ratios steer the aggregation fate of #αsynuclein" from Christian Blum and Mireille Claessens.
#LipidMembranes #ProteinAggregation #Amyloid
authors.elsevier.com/a/1kgCK3S6Gf...
Available online - the Review "PARPs and ADP-ribosylation-mediated #biomolecularcondensates: determinants, dynamics, and disease implications" from @leunglab.bsky.social and colleagues.
#phaseseparation #proteincondensation #proteinaggregation
Free access at: authors.elsevier.com/a/1kZlO3S6Gf...
So excited to have finally made it to a FENS-Hertie Winter School in Austria! Arrived to see everyone in post-dinner working group mode. The learning never stops!🥳🧠
#FENSSchool on #proteinaggregation and its consequences in #neurodegenerativedisorders
#Hertie
@lucbuee.bsky.social & Susanne Wegmann
Hello #neuroscience community. I am an Assistant Professor at IISER-Thiruvananthapuram working on Parkinson's disease biology. Looking to connect with other researchers in the field of #neurodegeneration
#movementdisorders #parkinson #proteinaggregation #HiSciSky #AcademicSky
Scientists at #UniMainz and @imbmainz propose a concept of a #ProteinAggregation clock to measure #ageing and #health / Potential new way for detecting the risk of getting #AgeRelatedDiseases...
Forschende von #UniMainz u @imbmainz schlagen Konzept einer #Proteinaggregation|suhr zur Messung von #Alterung u #Gesundheit vor / Neue Möglichkeit zur Bestimmung des Risikos altersbedingter Krankheiten...
Research Article: Proinsulin folding and trafficking defects trigger a common pathological disturbance of endoplasmic reticulum homeostasis -Protein Science
#proteinaggregation #misfolding #proteinfolding #proinsulin #disulfidebonds #betacells #Diabetes
onlinelibrary.wiley.com/doi/full/10....
