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#DNAReplication

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Posts tagged #DNAReplication

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Detection of DNA base modification using nanopore sequencing 2026 In this comprehensive two-day course, participants will learn how to use nanopore sequencing to detect DNA base modifications.

Registration open!

Led by our #DNAReplication Group, this online course covers principles and practice of modified base detection, visualisation, and experimental considerations for ultra long #sequencing reads. 🧬💻

🗓️ 13-14 May 2026
📍 Online (via Zoom)
👉 buff.ly/3ac0FPQ

Image: @nanoporetech.com

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We're so glad to hear our content brought more joy to #SCLAmbassador Minu's classroom. If you haven't already, make sure to check out her lesson plan on #DNAreplication with Meselon and Stahl's famous experiment: bit.ly/sclminu

Stay tuned next week to meet our 2026 #SCLAmbassadors!

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What the video shows is a magnificent and precise machine of the DNA replication, definitely created, some people would say by God, others aliens, whoever made it, is someone beyond our comprehension, believe it.
#dnareplication #science #god #aliens #dna

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📢 One more week to go... exciting fully funded #PhD position for UK candidates to work across #ICR and #Imperial on novel mechanisms in genome stability and #CancerResearch.

#PhDStudentship #LifeSciences #DNAReplication #CRISPR

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Learn all about #genetics with our convenient & discounted bundle! Cover #transcription, #translation, #proteinsynthesis #DNAreplication, #PCR & more! Details are here: buff.ly/4xXq8Su

#EduSky #iteachbio #DNA #biologyteacher

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#EPI
DNA replication coordinates with cell metabolism, fundamental for growth. Recent advances show metabolic cues directly impact replication fork stability and function!🧬⚡
Details: www.maxapress.com/article/doi/10.48130/epi...
#epigenetics #dnareplication #cellmetabolism #stability

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Did you know it takes a human cell only 8 hours to replicate 3 BILLION base pairs of DNA for cell division? Unbelievable. Learn how it happens with our DNA Replication paper model! Find out more here: buff.ly/rJStomA

#EduSky #DNA #DNAreplication #celldivision #mitosis #iteachbio #biologyteacher

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Detection of DNA base modification using nanopore sequencing 2026 In this comprehensive two-day course, participants will learn how to use nanopore sequencing to detect DNA base modifications.

Registration open! Led by our #DNAReplication Group, the online course covers principles and practice of modified base detection, visualisation, and experimental considerations for ultra long #sequencing reads. 🧬

🗓️ 13-14 May 2026
📍 Online (via Zoom)

@nanoporetech.com

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#Yeast RNase H1 responds to unscheduled, stress-inducing #RNA-DNAhybrids. Overexpressed Rnh1 leaves wt cells unaffected, but clears dysregulated RNA–DNA hybrids in mutants and promotes #DNAreplication at transcription-replication conflict sites. Read more:
www.yeastgenome.org/reference/S1...

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The genetic and biochemical basis of human leading strand synthesis.
Agnarelli, Alessandro et al.
Paper
Details
#DNAReplication #LeadingStrand #Genetics

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Did you know that the 3 billion base pairs of DNA in human cells is copied in about 8 hours? But how? Our DNA Replication paper model shows you how!
Find out more here: buff.ly/a036Nj3

#EduSky #DNAreplication #DNApolymerase #helicase #primase #iteachbio #biologyteacher #genetics #DNA #celldivision

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We’re grateful to our Bronze sponsor @proteintech.bsky.social for supporting this week’s seminar.

#DNAReplication #GenomeStability #MolecularBiology #LifeSciences

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We’re delighted to welcome Prof. Grant Stewart (Uni. of Birmingham) for our next BLS Seminar Series talk:
“The integrity of the DNA replication process is intimately linked with maintaining genome stability.” 🧬
#DNAReplication #GenomeStability #MolecularBiology #LifeSciences

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#archaeasky #microsky #DNAreplication

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#DNAReplication Q:
1) Why does DNA Primase make RNA primers?
2) Why can't DNA Polymerase start a DNA chain?

Both facts seems quite inefficient, is it a relic from RNA world?

#phdlife #phdchat #phdvoice

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Great #EMBOdnatopology meeting in Szklarska Poręba: exciting science, inspiring discussions, and pleased to share our #DNAreplication work! Thanks to Dagmara Jakimowicz, Marcin Szafran & organizers! @embo.org

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📣Online now - the Feature Review "Just bypass it: Mechanisms of DNA damage tolerance" from Julien ‪@duxinlab.bsky.social‬ et al.

#DNAReplication #TranslesionSynthesis #TemplateSwitching #ForkReversal #Repriming #PCNAUbiquitination

Read it here 👉 authors.elsevier.com/a/1leHv3S6Gf...

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SYMPOSIUM OUTLOOK: #Telomeres at the nexus of #aging, #tumor suppression, and #inflammation: toward an understanding beyond #senescence
By Samuel Bloom & Jan Karlseder
➡️ https://bit.ly/410dJwg

#cshlsymp25 #DNAdamage #replicativesenescence #DNAreplication #crisis #cancer

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Structure of the 5-subunit RFC complex bound to the homotrimer DNA clamp PCNA, as determined by cryogenic electron microscopy. Courtesy of Marie Morimoto.

Structure of the 5-subunit RFC complex bound to the homotrimer DNA clamp PCNA, as determined by cryogenic electron microscopy. Courtesy of Marie Morimoto.

NIH researchers discovered Morimoto–Ryu–Malicdan syndrome, after finding shared symptoms and RFC4 gene variants in nine patients, offering hope for faster diagnosis and future treatments:
ow.ly/cmH450WGpaN.
#raredisease #Mendeliandisorder #DNAreplication #MedSky #neuroskyence

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It’s interesting how an offside project can bring so much value. Working on ORCs gave me new experiences, deeper insights into #DNAreplication, and some of the most fun I have had giving talks. #Orc #LOTR
Read more in @elife.bsky.social Version of Record:
elifesciences.org/articles/102...

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⭐NAR Breakthrough!⭐

🧬Mutation rates at the 3' end of DNA primer strands vary with run length. 4 TIM pathways in yeast DNA replication may be universal and linked to human disease.

📖 doi.org/10.1093/nar/...

#YeastGenetics #Genomics #DNAReplication #MolecularBiology

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DNA is amazing. Show your students how #DNA is copied in cells with our DNA Replication model then compare it with our #PCR model! Find out more here:
DNA Replication: buff.ly/iYtYbP6
PCR: buff.ly/ZEyXZx6

#EduSky #genetics #DNAreplication #iteachbio

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Franklin W. Stahl, 95, Dies; Helped Create a ‘Beautiful’ DNA Experiment

In 1958, #FranklinStahl and #MatthewMeselson conducted what’s often called “the most beautiful experiment in #biology,” providing strong evidence for the #Watson and #Crick hypothesis that #DNAreplication is semiconservative.

🧬 ➡️ 🧬 ➕ 🧬

www.nytimes.com/2025/07/07/s...

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DNA polymerase α/primase extraction from chromatin by VCP/p97 restricts ATR activation during unperturbed DNA replication - Nature Communications The replication stress response ensures genomic stability throughout DNA duplication. Here, the authors show that VCP/p97 extracts the DNA polymerase α/Primase complex from chromatin, preventing exces...

Just published!

Lecona (@emlecona.bsky.social ) & Méndez #RepliFate labs show that VCP/p97 removes Pol α/primase from chromatin to avoid excess ATR activation during normal #DNAreplication

VCP/p97 = checkpoint gatekeeper!

Read the full study: doi.org/10.1038/s414...

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We’re excited to welcome artist Helen Pynor to @cbm-csic-uam.bsky.social as part of the #RepliFate artist-in-residence program! 🎨🧬

From June 24–July 5, she’ll explore how #DNAreplication shapes cell fate & cancer, bridging science & art with our researchers.

#SciArt #ArtInScience

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#DNAReplication
#GenomeStability
#MolecularBiology
#Biophysics
#SingleMolecule
#FluorescenceMicroscopy
#ForceSpectroscopy
#Replisome
#CancerResearch
#CellBiology
#MolecularMachines
#LiveScience
#ReplicationStress

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NEW preprint from the @houseleylab.bsky.social shares exciting new TrAEL-seq updates allowing use in mammalian cells (comparable to OK-seq) and higher throughput.
#CellCycle #DNA #DNAreplication #protocols
🧬 🖥️

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2. DNA damage and replication issues are inherited, impacting future cell generations.
3. Identified distinct polyploidization routes with varying effects on genome integrity.
4. Provides insights into early cancer development & therapy resistance.

#CancerResearch #DNAReplication #CellBiology

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🧬When genome duplication goes off-script...
DNA replication is a finely tuned process, until it isn’t… Join John Diffley (Crick) as he unpacks how cells initiate replication and what happens when the system fails. A must-see for fans of fundamental mechanisms!
#DNAReplication #CellCycle #LMBIP2025

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Starting point of DNA replication mystery solved The question of where DNA replication starts in the human genome has finally been addressed, with the conclusion it is largely random.

💬 “When we looked at the replication start sites we’d identified, we discovered only 20% of them had been reported previously. The majority were newly discovered with this approach."

📃 Researchers use ultra #longreads to reveal where #DNAreplication starts in the #humangenome: buff.ly/pQWGasr

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