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Posts tagged #SysBio

Don't be clueless! Better, understand how Julia thinks:
@code_lowered 2 + 3
@code_lowered 2 + 3.0
@code_lowered 2.0 + 3.0

Code better. Code smarter.
#JuliaLang #computing #sysbio #systemsbiology #qbio

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High-throughput omics studies > lots of data transformations > 5,000 correlations to be tested through experiments.
Toy models with few parameters > the design principles behind the complexity of Life.
True Systems Biology: fewer spreadsheets, more ‘Aha!’ moments. #sysbio #mathbio #physicsoflife

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Signed Networks: theory, methods, and applications Signed networks provide a principled framework for representing systems in which interactions are not merely present or absent but qualitatively distinct: friendly or antagonistic, supportive or confl...

Another review article worth bookmarking: Signed Networks: theory, methods, and applications."
arxiv.org/abs/2511.17247
Perfect for my Systems Biology course.

#sysbio #complexsystem #graph #network #compbio #mathbio

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Many bugs don't scream. They whisper in wrong units. Using units in your code can save you. Again, Julia helps in that.

using Unitful
D = 0.01u"mm^2/s" # 0.01 mm^2 s^-1
t = 100u"s" # 100 s
√(2D*t) # 1.4142 mm

#julialang #computing #sysbio #systemsbiology

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Identical genome. Same environment. Totally different life choices. Turns out even cells have an identity crisis. #sysbio #physicsoflife

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In biology, we’re still busy naming T cells and debating EMT or autophagy — a bit like arguing over bird names while the real wonder lies in understanding how they fly.

#complexsystem #PhysicsOfLife #sysbio

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Dear developmental biologists, Julia comes with a Zygote that auto-differentiates. 😀

using Zygote
f(x) = x^2 + 3x + sin(x)
f'(2.0) # returns 6.58385

#Julialang #mathbio #qBio #compbio #sysbio #systemsbiology

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LOVE the promise of increasing support for data-driven biology. There is SO much data out there waiting to be mined & correctly organized to spark discovery.

#sysbio #insilico

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Wet lab? Dry lab? I prefer the Symbolic lab.
Math-Bio isn't just HPC runs— derivations & proofs matter too. As always, Julia helps.

using Symbolics
@variables x y a b c d m n
f = [a/(1+y^n)-b*x, c/(1+x^m)-d*y]
J = Symbolics.jacobian(f,[x,y])

#Julialang #mathbio #computaionalbiology #sysbio

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Calling any large, well-organised dataset "Systems Biology" is a bit like calling a census "social theory." Essential, powerful, and impressive — yes. But the explanations, through generalised theories/models, still have to be earned. #systemsbiology #sysbio #physicsoflife

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Engineering Basal Cognition: Minimal Genetic Circuits for Habituation, Sensitization, and Massed–Spaced Learning Cognition is often associated with complex brains, yet many forms of learning—such as habituation, sensitization, and even spacing effects—have been observed in single cells and aneural organisms. The...

Does a cell have a 'mind' - say a proto-mind or basal cognition? Although it was once a fringe idea, recent experimental and mathematical works are accumulating in its support. Here is an interesting recent work: www.biorxiv.org/content/10.1... #complexsystem #systemsbiology #sysbio

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Teaching Gillespie algorithm in the Systems Biology class and it reminds that Life is a process with long stretches of exponential calm punctuated by bursts of stochastic drama.

#stochastic
#random
#mathbio
#systemsbiology
#sysbio

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I left wet-lab experiments 'cause those are damn slow! Equations are better; they evolve faster than organisms. 🙂#mathbio #systemsbiology #sysbio #qbio #computaionalbiology

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What a week! A huge thank you to all the students and teachers for the for the engaged discussions, thoughtful questions, and good vibes. Rock on, and stay curious! 🤓 ✨

#VeniceEvoDevo #levels #morphogenesis #sysbio #evodevo

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Wheels turning: CHO cell modeling moves into a digital biomanufacturing era. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.06.035

Wheels turning: CHO cell modeling moves into a digital biomanufacturing era. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.06.035

🧪 Could digital modeling redefine how we grow CHO cells for biologics?

🔗 Wheels turning: CHO cell modeling moves into a digital biomanufacturing era. DOI: doi.org/10.1016/j.cs...

📚 CSBJ: www.csbj.org

#Biomanufacturing #CHO #SysBio, @csbj.org, @elsevierlsj.bsky.social, @elsevierconnect.bsky.social

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PNAS Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

Paper:
www.pnas.org/doi/10.1073/...

🧪 #sysbio @uvacvrc.bsky.social

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Logic-based modeling of biological networks with Netflux Molecular signaling networks drive a diverse range of cellular decisions, including whether to proliferate, how and when to die, and many processes in between. Such networks often connect hundreds of ...

From @jsauce7.bsky.social and colleagues, in @plos.org #Computational #Biology | Logic-based modeling of biological networks with Netflux | #Bioinformatics #Education #Tutorial #SysBio #OpenEducationalResource 🧬 🖥️ 🧪 🔓
⬇️
journals.plos.org/ploscompbiol...

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Terrific paper by post-doc @aclark.bsky.social in @plos.org
Comp Biol. This tutorial enables students and biologists to simulate biological networks with our tool Netflux, no programming required! #sysbio #cardiosky 🧪

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#python #jax #sysbio #scicomp #opensource

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What unique insights can modeling approaches capture about the immune system? The immune system, optimized by evolution to maintain health and prevent disease, is remarkably good at what it does. It detects pathogens and monitors physiological stresses with a sensitivity and selectivity that far surpasses that of man-made biosensors. It then mounts potent yet precise responses, enabling the body to maintain homeostasis amid varying internal milieu and external threats.

Thoughts from leaders of systems #immunology how mechanistic models can leverage omics/ML for deeper understanding of how our immune system works #sysbio @cp-cellsystems.bsky.social
www.cell.com/cell-systems...

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Toy models like Ising model and sandpile models play crucial role in physics. Can we list some of the mathematical models in biology as Toy models? What would be your list for impactful Toy Models in Biology?

#mathbio #theory #theoryoflivingmatter #qbio #systemsbio #sysbio

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OncoLogics: When cancer treatment becomes logical
OncoLogics: When cancer treatment becomes logical YouTube video by European Partnership for Personalised Medicine

Happy to see new & familiar faces here!👋

If you don't know me & you're curious to see what my latest work is all about, have a look at this video:
youtu.be/7zlKVulLGsg?...
💻🧪

#SysBio #CompBio

PS.Feel free to like the video on Yt as it's part of a competition between #ERAPerMed funded projects!😊

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Happy day to the many wonderful taxonomists from #SSB #sysbio @sse-evolution.bsky.social and #BSA. Your work has inspired many cool math and stats tools to study the tree of life and the evolution of many cool traits. I am looking forward to a brighter collections-based future!

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In my way to the #SBHD (systems biology of human disease) conference in #Nashville @VanderbiltU @VUMChealth! Looking forward to some exciting science (thank you @CaptainSysBio for the invite!), not looking forward to the looong travel 😮‍💨
#sysbio #virology #cytokines

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ScienceDirect

Elegant #sysbio paper by @jgojalvo on modeling cellular response to pulsatile stimuli: www.sciencedirect.com/science/article/pii/S245...

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