Latest posts tagged with #cGAS on Bluesky
Weekend reading 🚨
A comprehensive #Review on the dual role of the #cGAS–#STING pathway in cancer, emphasizing its involvement in both tumour suppression and promotion, which might underlie the limited clinical success of cGAS–STING targeting in cancer therapy.
📖👇
Activation of the cGAS–STING pathway drives #RetinalInflammation in #endotoxin-induced #uveitis, while genetic deletion of #cGAS reduces #vitreous inflammation, vascular leakage, and #microglial activation. @fudan-university.bsky.social
#OpenAccess: doi.org/10.1016/j.ge...
A molecular mechanism in Naked Mole Rats enables DNA repair and delays aging [via Science.org] 🧪⚗️⚕️🐀🧬🏗️
"Unlike human cGAS, [...], the naked mole rat enzyme has four amino acid changes that [] enhance DNA repair,"
www.science.org/doi/10.1126/...
#aging #delay #DNA #repair #cGAS #naked #mole #rat
This week #JournalClub @labsoap.bsky.social #DNArepair #cGAS #STING @science.org #molerat 🐀 www.science.org/doi/10.1126/...
#LiveForever! Chen, Mao &co show @science.org that not all #cGAS are equals & that naked mole-rats one bears a 4 amino acid mutation which enhances DNA repair & when transferred in aged mice dampens frailty, hair graying, inflammatory & senescence markers! www.science.org/doi/10.1126/...
🏆 Nobel Prize 2025 Coming Soon | This Year’s Most Anticipated Breakthroughs
🛡️ Innate immunity = first defense & cancer fighter.
🧬 cGAS-STING: #cGAS senses foreign DNA → STING → IRF-3 & NF-κB → type I interferons & #cytokines → stronger #tumor #immunity. 🔗 https://ow.ly/foGZ50X2FLx
#NobelPrize
Daily Hack Notices: #tdktech, #molodspitz, #fluxergy, #std-iron, #cartonajesbernabeu, #nubox, #sumasaas, #gazomet, #cgas, #noblecorp, #epiafs, #chamonix-guides, #rggroup, #rgelectric, #biw-burger, #ip...
This week #JournalClub @LabSoap @cellpress.bsky.social #CGAS #DNAamplification #virus www.cell.com/cell/abstrac...
Excited to share our latest work out in @pnas.org! We show that the #SARSCoV2 nucleocapsid protein directly prevents DNA recognition of the immune sensor #cGAS by competing for DNA, which may delay early innate immune responses during infection. www.pnas.org/doi/epub/10.... #innateimmunity
#cGAS upregulation after #CardiacArrest triggers mitochondrial damage, #oxidativestress & #apoptosis. Pharmacologic (RU.521) or genetic inhibition of cGAS improved heart function, highlighting cGAS as a novel therapeutic target.
Read more: cvia-journal.org/inhibition-c...
#HeartFailure #Immunology
Together with the Roers Lab from @uniheidelberg.bsky.social and @bms-us.bsky.social we propose that controlled low level systemic activation of #cGAS by endogenous nucleic acids is a safe and effective way to boost #cancer #immunotherapy.
aacrjournals.org/cancerres/ar...
Gabo Birkus from @iocbprague.bsky.social is opening the last presentation stream at #BioVaria2025
#cGAS #CD3 #BioVaria #autoimmune
🎮 Canadian Game Awards 2025 Recap >>>
indiegamereviewer.com/canadian-gam...
#indiegames #indiegamedev #videogames #cgas
Styrax will be part of the Eh! Game Expo at the 2025 Canadian Game Awards on February 15th in Toronto!
Play BUTTON MAN alongside 14 other great Canadian games at the TIFF Lightbox – and then attend the CGAs!
More info here: cgameawards.com/ehgameexpo
#CanadianGameAwards #CGAs #indiedev #ButtonMan
Stimulating #labmeeting today by #postdoc Salwa Soussi, PhD on #aging and how it is modulated by novel #RNAdrug #TY1. Strong evidence for central role of #cGAS #STING in cardiac #senescence. Animated discussion followed!
Showcasing this exciting paper from our good friends Fachinetti lab @institutcurie.bsky.social. #Centromere inactivation triggers #senescence: mis-segregated chromosomes deform the nuclear envelope and activate TORC2-ATR. We helped with #cGAS and some key suggestions.
doi.org/10.1038/s415...
This week in #Science #Immunology: Glen Barber & colleagues report that #cGas – #STING signaling in phagocytosed DNA-damaged cells facilitates #APC activation via formation of STING-inducible endosomal vesicles (SIEVES) containing immune-activating proteins and cytosolic DNA!
Tell your friend that the drones can be spotted On the Lower Cape, over Nantucket Sound, in Harwich, Harwichport, Chatham. Also spotted hovering over Upper Cape: Barnstable & Osterville, near #Otis / #CGAS #CapeCod. Also on Outer Cape: Wamsutta Road, Eastham.
Good luck!
#Drones #UAP #UFOsky #UFO
#Drones #CapeCod #Boston #Massachusetts #Northeast #Connecticut #NewYork #NewJersey #Jersey #UFO #UFOsky #EADS #CGAS #Otis #NORAD #Pentagon #DOD
#MedSky🧪#ImmunoSky Zhijian “James” Chen, winner of the 2024 Basic Research #LaskerAward on the approaches he and his lab implemented in the discovery of #cGAS, a DNA-sensing enzyme that triggers inflammation
jamanetwork.com/journals/jam...
Next is a review and thought piece by Imler, Cai, Meignin, and Martins. Their work on #cGAS - #STING signalling the last few years has been 🔥
Their work highlights just how diverse #antiviral #immunity is across species. Some neat ideas in this piece for #immune researchers in general. 🧵 3/n
