Latest posts tagged with #damps on Bluesky
#Review in #MedComm_Biomaterials_and_Applications
Recent Advances and Evolving Strategies of Photothermal Immunotherapy in Pancreatic Cancer Treatment doi.org/10.1002/mba2...
#ImmunogenicCellDeath #PDAC #CAR_T #immunotherapy #PancreaticCancer #PhotothermalTherapy #DAMPs
This review explores how #PatternRecognitionReceptors bridge innate and adaptive immunity by sensing #PAMPs and #DAMPs, detailing their signaling, regulation, and therapeutic relevance in #autoimmunity and #cancer. #medsky
#OpenAccess in #STTT: doi.org/10.1038/s413...
An overview on the structure, activation & downstream effects of #gasdermin with implications in various diseases and #targeteddrugdevelopment. #Pyroptosis, #DAMPs #GSDMoligomerization #GSDMDagonists #DrugDelivery
#OpenAccess: amm-journal.org/index.php/20...
Mitochondria have been detected in human blood in a “cell-free” form, but their clinical relevance is unknown. This paper shows elevated levels of mitochondria in the circulation of trauma patients and associations with coagulation. #mitochondria #polytrauma #damps
journals.lww.com/jtr...
Mitochondria have been detected in human blood in a “cell-free” form, but their clinical relevance is unknown. This paper shows elevated levels of mitochondria in the circulation of trauma patients and associations with coagulation. #mitochondria #polytrauma #damps
journals.lww.com/jtr...
Mitochondria have been detected in human blood in a “cell-free” form, but their clinical relevance is unknown. This paper shows elevated levels of mitochondria in the circulation of trauma patients and associations with coagulation. #mitochondria #polytrauma #damps
journals.lww.com/jtr...
2️⃣0️⃣ Possibility 1 - Caspase-11 as a 3D Threat Sensor
Membrane disruptions can expose acyl chains, providing a context-dependent trigger for caspase-11 activation. Caspase-11 may also bind phosphoinositides to guard against bacterial escape. #Immunology #Caspase11 #DAMPs
1️⃣9️⃣ Self-Ligand Detection: Evolutionary Error or Advantage?
Caspase-11’s ability to detect both LPS and self-lipids aligns with Janeway’s PAMP concept. But is self-ligand detection an evolutionary error or an advantage? #Immunology #Caspase11 #DAMPs
