Latest posts tagged with #dsRNA on Bluesky
New work @jem.org from Duan, Fairbrother et al. @brown.edu reveals how intronic Alu repeats and #RNA metabolism shape endogenous #dsRNA levels and cell-intrinsic immunity. rupress.org/jem/article/...
#InnateImmunity #Inflammation
New work from Duan, Fairbrother et al. @brown.edu reveals how intronic Alu repeats and #RNA metabolism shape endogenous #dsRNA levels and cell-intrinsic immunity. rupress.org/jem/article/...
#InnateImmunity #Inflammation
Recent article from the lab published in @jacs.acspublications.org. Big congrats to first author Zainab Rashid for leading the study and great collaboration with @tomngrossmann.bsky.social and Jocelyne Vreede labs!😃
doi.org/10.1021/jacs...
#singlemolecule #dsRNA #RNAtherapeutics
🧬 CRISPR screen uncovers C9ORF50 as a key regulator of #cancer immune evasion!
⚙️ Blocking this splicing factor triggers #dsRNA buildup, Type I IFN activation & strong T-cell recruitment.
onlinelibrary.wiley.com/doi/10.1002/...
Detect and quantify dsRNA contamination in IVT mRNA with the Lumit® dsRNA Detection Assay.
• No cross-reactivity with ssRNA or DNA
• Not sequence- or size-dependent (≥30bp)
Learn more: https://tinyurl.com/dsRNAQuantification
#dsRNA #DrugDiscovery
Drs @minealtinli.bsky.social @spleonard1.bsky.social @alainkohlvirology.bsky.social & @mosquitomicrobe.bsky.social review #bacteria-mediated #dsRNA delivery for #mosquito-borne #virus control. #RNAi #vectorcontrol #symbiont #engineering #mosquito #arbovirus
www.cell.com/trends/paras...
Detect and quantify dsRNA contamination in IVT mRNA with the Lumit® dsRNA Detection Assay.
• No cross-reactivity with ssRNA or DNA
• Not sequence- or size-dependent (≥30bp)
Learn more: https://tinyurl.com/dsRNAQuantification
#dsRNA #DrugDiscovery
Comparison of convergent and divergent T7 RNA polymerase promoters for the production of dsRNA. Analysis was performed to quantify the dsRNA produced and measure dsRNA product quality #dsRNA #T7Polyermase bit.ly/4lZpBXl
“I’ve heard of mRNA, but what is ‘dsRNA’?”
Double-stranded RNA forms naturally during cell processes or viral infections, triggering immune responses.
In RNA therapeutics, unintended dsRNA can impact efficacy and safety.
Read the blog here: https://tinyurl.com/2cjmuy3x
#DrugDiscovery #dsRNA
New work in #RESInsectMolecBio
#TcCYP4C1 in combination with trehalose to cope with high-CO2 stress in #Tribolium castaneum (#Coleoptera)
doi.org/10.1111/imb.12997
#PestManagement #dsRNA
@sassanasgari.bsky.social @gulianusslab.bsky.social @wiley.com
dsRNA contamination in IVT RNA?
It can trigger immune responses and affect your results.
Detect it reliably with anti-dsRNA monoclonal antibodies from VectorLabs – specific, sensitive, and ideal for QC.
#dsRNA #IVT #RNAquality #JenaBioscience #Antibodies #LabEssentials #QualityControl
Happy to share yet another story back from my days as a postdoc 👇 we uncovered how the J2 antibody specifically recognizes #dsRNA. J2 is a quintessential tool used to discover #RNA, QC #RNA therapeutics and much more
CELF2 suppresses immunostimulatory endogenous RNAs that activate the RIG-I-MAVS pathway in macrophages, preventing type I IFN-signature. Congrats to Julian Smith, Olivia Kern, and all the co-authors for their hard work! #innateimmunity #dsRNA #IFN
www.biorxiv.org/content/10.1...
Graphical abstract of: Insecticide resistance management scenarios differ for RNA-based sprays and traits
Learn how insecticide resistance management scenarios differ for RNA-based sprays and traits, in our new #RESInsectMolecBio article 🧬
Read the full #OpenAccess paper about #dsRNA insecticides 🔽
buff.ly/vR7CCyI
@sassanasgari.bsky.social @gulianusslab.bsky.social @wiley.com
Study reveals how $RNA travels between cells to control #genes across #generations
#dsRNA #SID-1 #sdg-1 #jumpinggenes #epigenetic #C_elegans
phys.org/news/2025-02...
#dsRNA #BuddingYeast
Pervasive formation of double-stranded RNAs by overlapping sense/antisense transcripts in budding yeast mitosis and meiosis
Szachnowski et al.
m.rnajournal.cshlp.org/content/earl...
ANT2 is identified as a translocon facilitating mitochondrial RNA transport to the cytosol, influencing immune responses and potential autoimmune risks. Key for therapeutics! #RNA #dsRNA #autoimmunity #mitochondria #research PMID:38811766, Cell Res 2024
This week in #ScienceImmunology: @jackiheraudfarlow.bsky.social , Carl Walkley, & colleagues used a genome-wide #CRISPRscreen to determine that a GGNBP2– CNOT10/11 complex is required for the accumulation of unedited #immunogenic self- #dsRNA & its sensing by #MDA5!
Stressed mitochondrial RNA granules from our recent work on the cover of PNAS!
A photo by E. Recazens illustrating our new story led by M. Foged on the cytosolic control of mitochondrial RNA processing and innate immunity by #N6AMT1.
#mitochondria #dsRNA
Viral afterlife: SARS-CoV-2 as a reservoir of immunomimetic peptides that reassemble into proinflammatory supramolecular complexes
Resulting in cooperative, multivalent immune recognition and grossly amplified inflammatory responses.
#longterm #dsRNA #proinflammatory
www.pnas.org/doi/10.1073/...
Ximena's review is out, congratulation!
Toll-Like Receptor 3 in #Solid #Cancer and #Therapy #Resistance
by Ximena Maria Muresan, Jan Bouchal, Zoran Culig and Karel Souček
👉
#TLR3
#dsRNA
#Cytokines
#therapyresistance
mdpi.com/2072-6694/12/1…
