#IFN

Dr. Deanna Santer

@drdeannasanter.bsky.social

1 month ago

My son's homemade birthday gift for me yesterday is pretty great- a scientists vs viruses card game! 🎂🥳😲
Some nice artwork so far too!

Now to suggest some #IFN as a special weapon 😉

Ivan Zanoni

@lozanzi.bsky.social

2 months ago

Molecular, Cellular, Tissue, and Organismal Functions of Type III Interferons Type III interferons are essential immune mediators playing pleiotropic roles during health and disease. In this review, we highlight the molecular and cellular pathways that lead to the production of...

💥New paper alert!💥 What’s better than starting 2026 with an @annualreviews.bsky.social #Immunology, often a once-in-a-life honor ❤️?! Check it out if you want to know everything about type III interferons #IFN! Thanks to my wonderful team for their amazing work 🤗 doi.org/10.1146/annu...

Sara Sánchez-Serra

@sarasnchzs.bsky.social

2 months ago

🧫 Importantly, tumor microenvironment cues, including IFNγ signaling, upregulate PARP14 expression and enhance metastatic traits, highlighting a context-dependent role in EwS dissemination.

#tumormicroenvironment #TME #IFN #IFNgamma #IFNg

MedChemExpress

@medchemexpress.bsky.social

4 months ago

🔥Hot Off the Press | PLD4 mutations→ #SLE
This #Nature study (Qintao Wang et al.) identifies recessive #PLD4 loss-of-function mutations in SLE, revealing its key role in immune balance. PLD4 loss→ ssNA buildup→ #TLR7 /#TLR9 overactivation → #IFN surge→ autoantibodies→ SLE.

Dr. Deanna Santer

@drdeannasanter.bsky.social

4 months ago

What a great #Cytokines2025 meeting! Caught up with many #IFN scientists, made multiple new connections, had fun giving a talk & great to see those from UW Immunology all these years later. Always my fav conference 😀🥳 Thanks to all the organizers!🙏🏻 @cytokinesociety.bsky.social @ramlabuw.bsky.social

Dr. Deanna Santer

@drdeannasanter.bsky.social

4 months ago

#Cytokines2025 has begun- looking forward to a few days of networking, especially with #IFN friends from outside 🇨🇦 when it has been too long 😀
Despite the challenge of travel to the US at the moment, still 20 countries represented this year 🌎

#Cytokines25 @cytokinesociety.bsky.social

Dr. Deanna Santer

@drdeannasanter.bsky.social

4 months ago

Busy last few weeks with Italy pediatric IBD conference, chairing local equity symposium & now off to Seattle for #Cytokines2025! I haven't been able to attend the last 2yrs so excited to chat with fellow #IFN enthusiasts & give a talk 🥳 + always nice to visit where I did my PhD when not back often

Juan Lama

@juanlama.bsky.social

4 months ago

The IFIT2–IFIT3 Antiviral Complex Inhibits Translation Targeting Viral mRNAs Recognition of foreign RNA is critical for the innate immune response to viruses. Interferon (IFN)-induced proteins with tetratricopeptide repeats (IFIT) 2 and 3 are highly upregulated following viral infection, but mechanistic insight into their antiviral role is lacking. Here we demonstrate that short 5’ untranslated regions (UTRs), a characteristic of many viral mRNAs, can serve as a molecular pattern for innate immune recognition via IFIT2 and IFIT3. Structure determination of the IFIT2–IFIT3 complex at 3.2 Å using cryo-EM reveals a domain-swapped heterodimer that is required for recognition of the viral mRNA 5’ end, translation inhibition and antiviral activity. Critically, viral or host 5’ UTR lengths less than 50 nucleotides are necessary and sufficient to enable translation inhibition by the IFIT2–IFIT3 complex.   Accordingly, diverse viruses whose mRNAs contain short 5’ UTRs, such as vesicular stomatitis virus and parainfluenza virus 3, are sensitive to IFIT2–IFIT3-mediated antiviral activity. Our work thus reveals a pattern of antiviral nucleic acid immune recognition that takes advantage of the inherent constraints on viral genome size. Viruses generally have compact genomes, resulting in many viral mRNAs with short 5’ untranslated regions. An antiviral complex exploits this feature of viral mRNAs to selectively inhibit viral protein synthesis and repress viral replication.   Published in Nature Microbiology (Oct. 15, 2025): https://doi.org/10.1038/s41564-025-02138-w 

IFT2/IFIT3 form a stable heterodimeric complex that facilitates recognition of the 5’UTR region and inhibits translation of mRNA from several viruses. #IFN

Dr. Deanna Santer

@drdeannasanter.bsky.social

5 months ago

📢🥳 The #SanterLab is recruiting to have new people join the #IFN fun!

With #CIHR & other 💰:
1) joint tech with Dr Thomas Murooka for more of an immediate start - see umanitoba.ca/careers/ #41169
2) #Immunology PhD student
3) Postdoctoral fellow

Please see our Google lab website + dept website 😀

The Gregory Lab @ DukeU

@gregorylab.bskyverified.social

6 months ago

Tissue-Resident Macrophage and Dendritic Cell Cooperation Drives Type I IFN Immunity to Enteroviruses in the Liver Enteroviruses are major causes of neonatal morbidity and mortality, with echovirus infections commonly associated with severe disease, including acute liver failure. The human neonatal Fc receptor (hF...

New preprint out with #DukeMGC #scRNAseq data! 🧬🧪

Check it out: 'Tissue-Resident #Macrophage and #Dendritic Cell Cooperation Drives Type I #IFN Immunity to 4 #Enteroviruses in the Liver' by Emma Heckenberg & Duke's #CoyneLab www.biorxiv.org/content/10.1...

#singlecell #immunology

Juan Lama

@juanlama.bsky.social

7 months ago

mRNA Drugs Could Protect Against Almost Any Kind of Viral Infection mRNA drugs might be able to protect against a huge range of viruses by turning on key parts of our innate defences against infection. Just one weekly puff from an asthma-like inhaler might one day protect you from the viral infections that make winters miserable – and could even save your life in the event of another pandemic. That is the tantalising prospect raised by promising animal tests of an mRNA treatment that turns on our built-in viral defences. “You can think about this as a universal antiviral,” says Dusan Bogunovic at Columbia University in New York. Realising the full promise of this approach will require further development of the mRNA technology used in vaccines – but last week the US slashed funding for mRNA vaccine development. “I would be surprised if it didn’t have knock-on effects on efforts like this,” says Bogunovic. In addition to our body learning to recognise and target viruses with antibodies, it has lots of built-in defences. For instance, when a viral infection is detected, cells release a key signalling molecule called interferon. This turns on around 1000 genes, triggering the production of a wide array of antiviral proteins that work in many different ways: some block viral entry to cells, others inhibit the release of new viral particles. Not all of these proteins work against all viruses, but in combination they can make a big difference. “Our innate immune system is extremely powerful,” says Bogunovic.   The problem is that viruses, especially respiratory ones, replicate really fast, says Bogunovic, so can outpace the body’s ability to ramp up its innate defences. But if the body gets a head start on preparing these defences, this can limit viral replication and keep infections mild, even before the rest of the immune system kicks in. There were hopes that interferon could be used as a general antiviral, but it can have serious side effects. So Bogunovic and his colleagues are instead developing antivirals consisting of subsets of the 1000 proteins whose production is triggered by interferon. They selected 10 of these proteins and delivered them to cells in the form of mRNAs coding for them. mRNA delivery means the proteins are temporarily produced inside cells where they are needed, whereas ready made proteins are too large to get inside cells in sufficient quantities. Tests involving infecting human cells with a range of viruses, including flu and Zika, showed that this combination successfully boosted viral defences. In the body, this should provide a crucial head start. Next, the team then delivered these mRNAs to the lungs of golden hamsters. The mRNA cocktail successfully protected the hamsters against the SARS-CoV-2 virus, which causes covid-19, with a dramatic reduction in viral numbers compared with untreated animals. “I was like, ‘wow, this actually might be a universal antiviral’,” says Bogunovic. Existing antiviral drugs work only against specific viruses, so having a treatment that acts more broadly would be extremely valuable. The development of antibiotics like penicillin that can kill a broad range of bacteria revolutionised medicine. What’s more, some combinations of interferon-triggered proteins might be especially effective against specific viruses, says Bogunovic. So the same approach could also be used to develop more specific antivirals.   Delivering the mRNAs to a high-enough proportion of the specific cells at risk of infection will be crucial. This is where further development is needed, as it is still difficult to deliver mRNAs to specific cell types. “This is certainly exciting and could lead to very promising advances, but we are several steps down the line away from talking about a deployable, versatile countermeasure,” says Aris Katzourakis at the University of Oxford. “The research highlights the potential of mRNA technology beyond vaccines. The current trajectory in the US with mRNA vaccines will certainly and tragically slow down progress on both of these fronts.” While antibiotic resistance is now a major problem, Bogunovic thinks viruses are unlikely to evolve resistance to this kind of antiviral as long as they include a range of interferon-triggered proteins targeting different aspects of the viral lifecycle. This combination approach has proved successful with HIV treatments, for instance.   Research Published in Science Transl. Medicine (Aug. 13, 2025): https://doi.org/10.1126/scitranslmed.adx5758 

Administration of a set of mRNAs directing expression of ten IFN-I–stimulated gene (ISGs) confers broad antiviral activity in vitro and in vivo. #immunity #antiviral #IFN #ISG #Innateimmunity

Small Cap Strategist

@smcapstrategist.bsky.social

7 months ago

Small-cap stocks in new downtrend with AROON Oscillator, Mon Jul 28th - #AERT #BNTC #CASS #DMRC #EM #FMBH #IMAB #MPB #NRIM #RGP #XYF #UMH #SITC #OOMA #IFN #GEL #FVRR #CHPT #BFS #AGM #SEGG #WALD #ZJK - More: crystalequityresearch.com/ieading-indi... - #smallcap

Xu Zhou lab @ BCH & HMS

@xuzhoulab.bsky.social

7 months ago

to our surprise, acidic ph regulates a switch-like gene-specific inflammatory response in macrophages. with many interesting genes repressed or more induced at low pH #cytokine #IFN 6/n

tmoeckli

@tmoeckli.bsky.social

8 months ago

One aspect to highlight: Despite #signaling through the same #receptor, different #IFN subtypes induce distinct and in part contrary effects. Regulatory mechanisms seem to be deeply conserved.
Many thanks to the organizers @thebinderlab.bsky.social and Marieke Essers 3/3

Dr. Deanna Santer

@drdeannasanter.bsky.social

8 months ago

Abstract submitted & looking forward to getting back to regular #Cytokines meeting attendance after missing the last 2 yrs!! Deadline now extended to June 30. I hope to see many #IFN friends there too🥳

Bonus that visiting Seattle where my academic research career began with my #Immunology PhD 😀

Apodsky

@nasapodsky.bsky.social

9 months ago

Stunning 80-exposure mosaic of the M81 Galaxy Group, showcasing the grand spiral galaxy M81, its interacting neighbor M82, and numerous other galaxies. The image is overlaid with a vibrant Integrated Flux Nebula (IFN), a complex structure of diffuse gas and dust within our Milky Way. Imaged with a new wide-field camera at the Teide Observatory.

Astronomy Picture from 27/06/2017

The M81 Galaxy Group through the Integrated Flux Nebula

Source: https://apod.nasa.gov/apod/ap170627.html


#M81 #M82 #Galaxies #Nebula #Astronomy #Space #Cosmos #DeepSpace #AstroPhotography #TeideObservatory #CanaryIslands #MilkyWay #IFN #IntegratedFluxNebula

Angelo Pilotti

@angelopilotti.bsky.social

9 months ago

#IntegratedStressResponse #UnfoldedProteinResponse #DendriticCells #Interferon #ISR #UPR #DCs #IFN @ciml.bsky.social @cnrs.fr @cnrsbiologie.bsky.social @univ-amu.fr

Seth Thomas Scanlon

@immunoeditor.bsky.social

10 months ago

Human life within a narrow range: The lethal ups and downs of type I interferons Genetic studies of type I interferon signaling reveal the narrow physiological range that is compatible with and essential for life.

Yanick Crow & @casanovalab.bsky.social examine how human #monogenic disorders of type I #IFN signaling reveal the narrow physiological range essential for life!

David A. Hill, MD, PhD

@drdavidhill.bsky.social

10 months ago

Interferon-γ Signaling in Eosinophilic Esophagitis Affects Epithelial Barrier Function and Programmed Cell Death - PubMed These findings reveal that interferon, especially IFN-γ, plays a central role in epithelial cell dysfunction, significantly affecting gene expression, cellular differentiation, and barrier integrity. ...

Check out this awesome new article on #EoE and #IFN from the Ruffner lab!

pubmed.ncbi.nlm.nih.gov/39884574/

Ram Savan

@ramlabuw.bsky.social

11 months ago

CELF2 suppresses immunostimulatory endogenous RNAs that activate the RIG-I-MAVS pathway in macrophages, preventing type I IFN-signature. Congrats to Julian Smith, Olivia Kern, and all the co-authors for their hard work! #innateimmunity #dsRNA #IFN

www.biorxiv.org/content/10.1...

@openforis.bsky.social

11 months ago

📊 En el último día del taller #OpenForis #Arena en #Ecuador analizamos los datos de campo colectados ayer durante la visita a la parcela demostrativa en el Bosque Protector Jerusalem 👩🏻‍🔬👨🏽‍🏫👩🏽‍💻📊🌳🪵

#ForestData #Forestry #SoyForestal #IFN

Brett Hansen

@bretthansen.bsky.social

11 months ago

#M81 and #M82 from the backyard. Total exposure is about 24hrs in LRGB+Ha. Was able to pull out some faint #IFN in the L channel but still could use some more time and darker skies.

#astrophotography #astronomy #astrobackyard #spacetoday #curiosityofspace #astronomynerd #longexposure

Achille Broggi🧪👨🏼‍🔬🔬

@achillebro.bsky.social

1 year ago

This week we had two incredible speakers at @ciml.bsky.social, both #interferoSky fans. After @boulantlab.bsky.social talking about basal #IFN lambda in the gut, today Nelson Gekara spoke about how the gut microbiota, and self nucleic acids affects basal #IFN-I systemically!

Achille Broggi🧪👨🏼‍🔬🔬

@achillebro.bsky.social

1 year ago

#interferonFriendorFoe ? So happy to have hosted my friend @boulantlab.bsky.social today at @ciml.bsky.social , showing nice new data on how basal #IFN lambda is essential for tight junction formation in epithelial cells! Very nice work from him and @meganstanifer.bsky.social

Anna Kajaste-Rudnitski Lab

@kajastelab.bsky.social

1 year ago

Congratulations to Ilaria for successfully defending her #MSc thesis on type I #IFN signalling in a cellular model of the #AicardiGoutièresSyndrom with full marks! 🥳🥳🥳 This is also the first MSc graduation of the lab 100% from Pavia! 🤩

Apodsky

@nasapodsky.bsky.social

1 year ago

A stunning close-up image of Polaris, the North Star, nestled within the faint gas and dust clouds of the Integrated Flux Nebula (IFN). The image is digitally enhanced to highlight the nebula, with Polaris shining brightly near the center. Several other stars are visible, offering a glimpse into the celestial neighborhood surrounding our North Star. The image shows the beauty and complexity of our galaxy.

Astronomy Picture from 28/04/2021

North Star: Polaris and Surrounding Dust

Source: https://apod.nasa.gov/apod/ap210428.html


#Polaris #NorthStar #IntegratedFluxNebula #IFN #Astronomy #Space #Stars #AstroPhotography #NightSky #Cosmology #Celestial #BigDipper #Vega

Trump

@trump.activitypub.awakari.com.ap.brid.gy

1 year ago

India's Modi to discuss buying more US oil and defense equipment with Trump: report

seekingalpha.com/news/4405381-indias-modi...

#nifty #sensex #ifn […]