☕Minetti, Omrani et al. report that delayed #intestinal #regeneration results from protein homeostasis stress and can be improved by modulation of the #polyamine pathway dynamics.
bit.ly/3N38jfy
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#polyamine
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Posts tagged #polyamine
🥂Congrats to Ori, Neri & co for their new Open Access study in our journal @natcellbio.nature.com showing that delayed #intestinal #regeneration results from protein homeostasis stress and can be improved by modulation of the #polyamine pathway dynamics.
bit.ly/3YhxZHC
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A huge thanks to Prof Peter Vangheluwe @kuleuvenuniversity.bsky.social for his wonderful OPDC seminar talk titled, ‘Modulating polyamines and #polyamine transport in #Parkinson’s disease’ & for spending the day with us @kavlioxford.bsky.social talking with our researchers @oxforddpag.bsky.social
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This review explores how #Polyamine levels & their dysfunction influence #OxidativeStress, #Mitochondrial metabolism, & #NeuronalInjury, offering insights into the mechanisms & potential #therapeutic targets of #NeurodegenerativeDiseases. #medsky
Read: link.springer.com/article/10.1...
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🚀From Bench to Paper | Nature: #Polyamine depletion + Arginine- and proline-free diet push MYCN #neuroblastoma cells toward differentiation & survival gain.
🌟GC7 Sulfate (MCE, HY-126470A) can be used to study cancer biology.
Read more: https://www.nature.com/articles/s41586-025-09564-0
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The remaining clusters were unique to bacteria🦠and included the most active deacetylases + depropionylases (cluster 3), and the bacterial #polyamine deacetylases (cluster 4), which have a different origin than the mammalian #HDAC10 and show interesting substrate selectivity.
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we messed up Rab5 - it's on the outside, rather than inside, of endosomes lol. we're fixing that! but it might be useful for ppl anyway, so we're releasing it now.
#polyamine
#polyamines
#spermidine
#spermine
#Cancer
#Parkinsons
#multiplesystematrophy
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