End of a busy day of PhD defenses. Congratulations to Dr Raffaella Parlato from my lab! And also to Dr Vasista Adupa from the Onck lab! Two #polyQ containing theses and defenses. :-)
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#polyq
Latest posts tagged with #polyq on Bluesky
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Posts tagged #polyq
New article @hdbuzzfeed.bsky.social about AMT-130: “UniQure and FDA No Longer in Alignment on Approval Pathway for AMT-130” en.hdbuzz.net/uniqure-and-... #huntingtonsdisease #polyQ
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New review article “Pathogenesis of polyglutamine diseases: Piecing together a complex molecular puzzle” by Esmeralda Villavicencio Gonzalez and Huda Zoghbi in the Journal of Experimental Medicine: doi.org/10.1084/jem.... #polyQ #huntingtonsdisease #ataxia
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Exogenous Huntingtin-Exon1 Aggregates Exhibit Distinct Levels of Toxicity to Caenorhabditis elegans | ACS Chemical Neuroscience pubs.acs.org/doi/abs/10.1... Interesting new paper on fundamental mechanisms in #huntingtonsdisease by Justin Legleiter’s team at the Univ of Nevada #polyQ
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Ashwani Thakur
Ashwani Thakur presents his talk
It was great to have Prof Ashwani Thakur, from IIT Kanpur, present his talk about #amyloid protein deposits in human disease and in plants (where they are ‘functional’). From #polyQ to plant seeds!
Catch him at the amyloid meeting in Hamburg. @landaulabcssb.bsky.social @cssbhamburg.bsky.social
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… I will be there, to discuss our recent paper on #ssNMR studies of antibodies binding to #polyQ protein fibrils ( #huntingtonsdisease ). (ref. dx.doi.org/10.1002/chem... ) …
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.. in #huntingtonsdisease but may also find effective use in studies of other aggregating #amyloid proteins, from #alzheimers to #parkinsons and beyond.
Read it all at the journal: doi.org/10.1002/chem... (where it is part of the “Hot Topic: amyloids” collection.
#nmrchat #polyQ #ssNMR
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.. Like in #Alzheimers or #Parkinsons, HD patient brains contain aggregated clumps of protein, which in HD feature parts of the huntingtin protein. This #polyQ protein forms amyloid-like fibrils, which are often detectable by the use of antibodies that selectively recognize exposed epitopes. ..
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Online: doi.org/10.1002/chem... “Probing How Anti-huntingtin Antibodies Bind the Fibrillar Fuzzy Coat Using Solid-State #NMR” - continuing our research on #huntingtonsdisease and in particular the aggregated #polyQ proteins involved. Here we looked at antibodies binding to the latter. #nmrchat
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.. These studies were done with our #polyQ huntingtin exon 1 proteins, but presumably similar things can happen with other #amyloid proteins. Moreover, a deeper mechanistic understanding of what happened here is still work in process…
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The mutation is at first glance a bit unusual, but it is actually far from unique: a repeating sequence of CAG codons has been expanded in HD patients. This translates to huntingtin (HTT) proteins featuring an expanded #polyglutamine (or #polyQ) segment. HD patients have >35 glutamines. (2/..)
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Now available at the journal: Integrative determination of atomic structure of mutant huntingtin exon 1 fibrils implicated in Huntington disease
doi.org/10.1038/s414...
#polyq #amyloid
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Interesting new paper in the Journal of Huntington Disease: An analysis of the native structure of #huntingtin (and other #polyQ proteins), informed my recent discoveries about the structural biology of huntingtin. #huntingtonsdisease #ataxia
doi.org/10.1177/1879...
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Amidst the stress of moving the #NMR instrument, a bit of happy news: our review article on #ssNMR studies of #polyQ protein aggregates is now online in Biochemical Society Transactions: doi.org/10.1042/BST2... #nmrchat #amyloid
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Yay! It is now online: our latest paper on the use #NMR spectroscopy to look at #amyloid formation by #polyQ peptides outfitted with a backbone modification, which allows photochemical control over beta-hairpin formation. Together with the groups of Szymanski and Feringa in #Groningen.
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