#HDACs

Günther Weindl

@weindl-lab.bsky.social

2 months ago

Crosstalk between NLRP3 Signaling and Histone Deacetylases in Inflammasome-Driven Diseases The NLRP3 inflammasome is a validated therapeutic target in inflammatory, metabolic, and neurodegenerative diseases. Epigenetic regulators, particularly histone deacetylases (HDACs), have emerged as key modulators of inflammasome priming and activation. Recent advances in medicinal chemistry have provided new chemical modalities for the mechanistic interrogation and the potential therapeutic modulation of NLRP3 signaling. This Perspective dissects the mechanistic interface between HDAC-dependent epigenetic control and NLRP3 signaling and highlights emerging chemical tools, including isoform-selective inhibitors and targeted protein degraders. We discuss the challenges of isoform selectivity, species-specific differences, and the therapeutic potential of HDAC-based strategies to attenuate aberrant NLRP3 activity while minimizing off-target effects. Understanding this epigenetic-inflammasome crosstalk may provide a framework for translating epigenetic modulation into innovative treatments for inflammasome-driven diseases.

🚀 New Perspective in J Med Chem out now! #HDACs meet #NLRP3 #inflammasome 🔬 Many thanks for the great collaboration! #DrugDiscovery
pubs.acs.org/doi/10.1021/...

Genes & Diseases Journal

@genesndiseases.bsky.social

4 months ago

This review highlights how #HDACs regulate endothelial and #SmoothMuscleCells and contribute to #Vascular #Pathogenesis. It also explores the therapeutic promise of HDAC inhibitors in #VascularDiseases. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

TranSpread

@transpread.bsky.social

7 months ago

A research team from the South China Botanical Garden of the Chinese Academy of Sciences published a study on August 14, 2024, in Horticulture Research, identifying a novel epigenetic regulator of tomato fruit ripening.
#Histone deacetylase #HDACs
Detail: doi.org/10.1093/hr/u...

Carlos Moreno-Yruela

@carlosmyruela.bsky.social

1 year ago

The mammalian Zn-dependent #HDACs are very diverse. They target various acyl-lysine modifications and acetylation of polyamines and other molecules.
This study led by Michael Lammers and Leonie Graf
(Uni Greifswald) trace these features in bacteria🦠!

t.co/LGfZ5Esmo5
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