Latest posts tagged with #Huntingtin on Bluesky
Open Postdoc position in our lab!
#actin #Huntingtin #cryoET #cellbio
If you enjoy working at the interface of cell biology, structural biology, and quantitative imaging, this could be an excellent fit.
ista.ac.at/en/job/postd...
Please share and feel free to reach out if there are questions!
🌟 G&D SPOTLIGHT 🌟
RESEARCH PAPER: ALOX5-mediated ferroptosis acts as a distinct cell death pathway upon oxidative stress in Huntington's disease
By Song et al. and Wei Gu
➡️ https://genesdev.cshlp.org/content/37/5-6/204.abstract
#huntingtonsdisease #ferroptosis #huntingtin #oxidativestress #ROS
#HuntingtonsDisease is caused by an error in #DNA, a mutation turns a normal #protein needed in the brain – the #huntingtin protein – into a killer of neurons. The goal of the treatment is to reduce levels of this toxic protein permanently, in a single dose www.bbc.com/news/article... #Science
If full-length #huntingtin indeed largely missing in these pathogenic aggregates, then targeting them (e.g. $PTCT $IONS/Roche) will do zilch. #CHDI2025
Interesting new paper in the Journal of Huntington Disease: An analysis of the native structure of #huntingtin (and other #polyQ proteins), informed my recent discoveries about the structural biology of huntingtin. #huntingtonsdisease #ataxia
doi.org/10.1177/1879...
Farkas, A., Zsindely, N., Nagy, G., KovAcs, L., Deák, P., Bodai, L. (2023). The ubiquitin thioesterase YOD1 ameliorates mutant #Huntingtin induced pathology in #Drosophila. Sci Rep, 13(1):2195 www.nature.com/articles/s41...
