#Keap1

@mol-biomed.bsky.social

2 months ago

Protein arginine methyltransferase 7-mediated arginine mono-methylation stabilizes SRY-box transcription factor 9 to promote non-small cell lung cancer progression - Molecular Biomedicine Non-small cell lung cancer (NSCLC) remains a leading cause of cancer-related mortality worldwide, underscoring the need for deeper insights into its molecular mechanisms. The SRY-box transcription fac...

#Research
Protein arginine methyltransferase 7-mediated arginine mono-methylation stabilizes SRY-box transcription factor 9 to promote non-small cell lung cancer progression doi.org/10.1186/s435...

#NSCLC #ArginineMono_methylation #SOX9 #PRMT7 #R160 #FBXW7 #KEAP1

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Onco404

@onco404.bsky.social

9 months ago

This integrated analysis of CodeBreaK 100 & 200 trials delves into biomarkers influencing sotorasib efficacy in KRAS G12C-mutated NSCLC.

#NatureMedicine

#Onco404 #Cancer #Kanser #LungCancer #Sotorasib #NSCLC #Biomarkers #PrecisionOncology #KRAS #TTF1 #KEAP1 #NRF2 #NFE2L2 #MedSky #OncSky

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SciSpace

@scispace.bsky.social

11 months ago

#Researchers have identified a unique genetic adaptation in horses, donkeys, and zebras: a premature stop codon in the #KEAP1 gene that, contrary to typical #genetic rules, enhances oxygen metabolism and #energy production, contributing to their exceptional athletic abilities.

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LKB1 (STK11)

@stk11.bsky.social

1 year ago

Frontiers | Metabolic barriers in non-small cell lung cancer with LKB1 and/or KEAP1 mutations for immunotherapeutic strategies Currently, immune checkpoint inhibitors (ICIs) are widely considered the standard initial treatment for advanced non-small cell lung cancer (NSCLC) when ther...

Given that current immune checkpoint inhibitors (ICIs) are less effective in patients with #LKB1 and #KEAP1 mutations, there is a pressing need for new treatment approaches. This paper suggests that combining ICIs with therapies targeting metabolic pathways could improve outcomes for these patients.

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Trends in Biochemical Sciences

@cp-trendsbiochem.bsky.social

1 year ago

Online now - the Feature Review "Regulating #Nrf2 activity: #ubiquitin ligases and signaling molecules in #RedoxHomeostasis" from Albena Dinkova-Kostova and colleagues.

#RedoxSwitch #Keap1 #SQSTM1

Read it here 👉 authors.elsevier.com/sd/article/S...

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MSK Library

@msklibrary.bsky.social

1 year ago

Pan-cancer analysis of biallelic inactivation in tumor suppressor genes identifies KEAP1 zygosity as a predictive biomarker in lung cancer The canonical model of tumor suppressor gene (TSG)-mediated oncogenesis posits that loss of both alleles is necessary for inactivation. Here, through …

Featured today by @MSKLibrary: Pan-cancer analysis of biallelic inactivation in tumor suppressor genes
#TumorSuppressorGenes #LungCancer #KEAP1
@mariaaperry.bsky.social @arielleelkrief.bsky.social @cdebyaniphd.bsky.social @arosebrannon.bsky.social

www.sciencedirect.com/science/arti...

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Seth Thomas Scanlon

@immunoeditor.bsky.social

1 year ago

The redox sensor KEAP1 facilitates adaptation of T cells to chronic antigen stimulation by preventing hyperactivation KEAP1 promotes persistent T cell immunity and a stem-like T cell response during chronic antigen stimulation by repressing NRF2.

Now in #Science #Immunology: Ziang Zhu, Tuoqi Wu, Chen Yao et al at UT Southwestern show that #NRF2 suppression mediated by the #redox sensor #KEAP1 is required for optimal expansion of #CD8 #TCells during chronic antigen exposure!